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https://hdl.handle.net/2183/48307 Novobiocin inhibits the antimicrobial resistance acquired through DNA damage-induced mutagenesis in Acinetobacter baumannii
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Jara, Luis M.
Pérez-Varela, María
Corral, Jordi
Arch, Marta
Cortés, Pilar
Aranda Rodríguez, Jesús
Barbé, Jordi
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Jara LM, Pérez-Varela M, Corral J, Arch M, Cortés P, Bou G, Aranda J, Barbé J. Novobiocin Inhibits the Antimicrobial Resistance Acquired through DNA Damage-Induced Mutagenesis in Acinetobacter baumannii. Antimicrob Agents Chemother. 2015 Oct 26;60(1):637-9.
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Abstract
[Abstract] Acinetobacter baumannii, a worldwide emerging nosocomial pathogen, acquires antimicrobial resistances in response to DNA-damaging agents, which increase the expression of multiple error-prone DNA polymerase components. Here we show that the aminocoumarin novobiocin, which inhibits the DNA damage response in Gram-positive bacteria, also inhibits the expression of error-prone DNA polymerases in this Gram-negative multidrug-resistant pathogen and, consequently, its potential acquisition of antimicrobial resistance through DNA damage-induced mutagenesis.
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