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http://hdl.handle.net/2183/38771 The Effects of Testosterone on the Brain of Transgender Men
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Authors
Zubiaurre-Elorza, Leire
Cerdán, Sebastian
Uribe, Carme
Pérez-Laso, Carmen
Marcos, Alberto
Rodríguez del Cerro, Mª Cruz
Guillamon, Antonio
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Journal Title
Bibliographic citation
Zubiaurre-Elorza L, Cerdán S, Uribe C, Pérez-Laso C, Marcos A, Rodríguez del Cerro MC, Fernandez R, Pásaro E, Guillamon A (2021) The effects of testosterone on the brain of transgender men, Androgens: Clinical Research and Therapeutics 2.1, 252–260, DOI: 10.1089/andro.2021.0008
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Abstract
[Abstract] Transgender men (TM) experience an incongruence between the female sex assigned when they were born
and their self-perceived male identity. Some TM seek for a gender affirming hormone treatment (GAHT) to induce
a somatic transition from female to male through continuous administration of testosterone. GAHT
seems to be relatively safe. However, testosterone produces structural changes in the brain as detected by quantitative
magnetic resonance imaging. Mainly, it induces an increase in cortical volume and thickness and subcortical
structural volume probably due to the anabolic effects. Animal models, specifically developed to test the
anabolic hypothesis, suggest that testosterone and estradiol, its aromatized metabolite, participate in the control
of astrocyte water trafficking, thereby controlling brain volume
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Editor version
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Atribución 3.0 España
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Except where otherwise noted, this item's license is described as Atribución 3.0 España