Use this link to cite:
https://hdl.handle.net/2183/49057 Comparative activity of ceftibuten combinations with avibactam, ledaborbactam, and xeruborbactam against recombinant β-lactamase-producing Escherichia coli and contemporary WGS-characterized strains of carbapenemase-producing Enterobacterales
Loading...
Identifiers
Publication date
Authors
Sánchez-Peña, Lucía
Rodríguez-Pallares, Salud
Blanco Martín, Tania
Pérez-Rodríguez, Gloria
Aja-Macaya, Pablo
González-Pinto, Lucía
López-Hernández, Inmaculada
Aracil, Belén
Beceiro Casas, Alejandro
Advisors
Other responsabilities
Journal Title
Bibliographic citation
Sánchez-Peña L, Rodríguez-Pallares S, Blanco-Martín T, Pérez-Rodríguez G, Aja-Macaya P, González-Pinto L, López-Hernández I, Aracil García B, Beceiro A, Bou G, Arca-Suárez J. Comparative activity of ceftibuten combinations with avibactam, ledaborbactam, and xeruborbactam against recombinant β-lactamase-producing Escherichia coli and contemporary WGS-characterized strains of carbapenemase-producing Enterobacterales. Antimicrob Agents Chemother. 2026 Jul;70(7):e0019526.
Type of academic work
Academic degree
Abstract
[Abstract] We evaluated the activity of ceftibuten combinations with avibactam, ledaborbactam, and xeruborbactam against isogenic Escherichia coli and clinical Enterobacterales isolates producing broad-spectrum β-lactamases. Avibactam and ledaborbactam enhanced ceftibuten activity against transformants producing serine-β-lactamases. Ceftibuten/xeruborbactam was also active against VIM and some IMP producers. All combinations were active against OXA-48- and KPC-producing clinical isolates. Ceftibuten/xeruborbactam also retained activity against VIM-producing clinical strains. Susceptibility rates for MBL producers varied, depending on the CLSI or EUCAST breakpoints applied.
Description
Comparative study
Editor version
Rights
Attribution 4.0 International
Collections
Except where otherwise noted, this item's license is described as Attribution 4.0 International