Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis

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UDC.coleccionInvestigación
UDC.departamentoFisioterapia, Medicina e Ciencias Biomédicas
UDC.endPage140
UDC.grupoInvReumatoloxía (INIBIC)
UDC.institutoCentroINIBIC - Instituto de Investigacións Biomédicas de A Coruña
UDC.issue2
UDC.journalTitlePharmacogenomics Journal
UDC.startPage137
UDC.volume16
dc.contributor.authorFerreiro-Iglesias, Aida
dc.contributor.authorMontes, Ariana
dc.contributor.authorPérez-Pampin, Eva
dc.contributor.authorCañete, Juan D.
dc.contributor.authorRaya-Álvarez, Enrique
dc.contributor.authorMagro-Checa, César
dc.contributor.authorVasilopoulos, Yiannis
dc.contributor.authorSarafidou, Theologia
dc.contributor.authorCáliz, Rafael
dc.contributor.authorFerrer, Miguel Ángel
dc.contributor.authorJoven, Beatriz
dc.contributor.authorCarreira, Patricia
dc.contributor.authorBalsa, Alejandro
dc.contributor.authorPascual-Salcedo, Dora
dc.contributor.authorBlanco García, Francisco J
dc.contributor.authorMoreno-Ramos, Manuel J.
dc.contributor.authorFernández-Nebro, Antonio
dc.contributor.authorOrdóñez, María del Carmen
dc.contributor.authorAlegre-Sancho, JJ
dc.contributor.authorNarváez, Javier
dc.contributor.authorNavarro-Sarabia, Federico
dc.contributor.authorMoreira, Virginia
dc.contributor.authorValor, Lara
dc.contributor.authorGarcía-Portales, Rosa
dc.contributor.authorMárquez, Ana
dc.contributor.authorMartín, Javier
dc.contributor.authorGómez-Reino, Juan J.
dc.contributor.authorGonzález, Antonio
dc.date.accessioned2026-07-02T09:05:05Z
dc.date.available2026-07-02T09:05:05Z
dc.date.issued2015-04-21
dc.description.abstract[Abstract] Genetic biomarkers could be useful for orienting treatment of patients with rheumatoid arthritis (RA), but none has been convincingly validated yet. Putative biomarkers include 14 single nucleotide polymorphisms that have shown association with response to TNF inhibitors (TNFi) in candidate gene studies and that we assayed here in 755 RA patients. Three of them, in the PTPRC, IL10 and CHUK genes, were significantly associated with response to TNFi. The most significant result was obtained with rs10919563 in PTPRC, which is a confirmed RA susceptibility locus. Its RA risk allele was associated with improved response (B=0.33, P=0.006). This is the second independent replication of this biomarker (P=9.08 × 10(-8) in the combined 3003 RA patients). In this way, PTPRC has become the most replicated genetic biomarker of response to TNFi. In addition, the positive but weaker replication of IL10 and CHUK should stimulate further validation studies.
dc.description.sponsorshipFunding was provided by grants PI11/01048, PI12/01909 and by RETICS Program, RD12/0009/0008 and RD12/0009/0004 (RIER) of the Instituto de Salud Carlos III (Spain) that are partially financed by the European Regional Development Fund of the European Union.
dc.identifier.citationFerreiro-Iglesias A, Montes A, Perez-Pampin E, Cañete JD, Raya E, Magro-Checa C, Vasilopoulos Y, Sarafidou T, Caliz R, Ferrer MA, Joven B, Carreira P, Balsa A, Pascual-Salcedo D, Blanco FJ, Moreno-Ramos MJ, Fernández-Nebro A, Ordóñez MC, Alegre-Sancho JJ, Narváez J, Navarro-Sarabia F, Moreira V, Valor L, García-Portales R, Marquez A, Martin J, Gómez-Reino JJ, Gonzalez A. Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis. Pharmacogenomics J. 2016 Apr;16(2):137-40.
dc.identifier.doi10.1038/TPJ.2015.29
dc.identifier.issn1473-1150
dc.identifier.urihttps://hdl.handle.net/2183/48734
dc.language.isoeng
dc.publisherSpringer Nature
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI12%2F01909/ES/Descripción epidemiológica, clínica, farmacocinética, inmunológica y genética de los pacientes con artritis reumatoide que son refractarios al tratamiento con dos o más fármacos biológicos/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//RD12%2F0009%2F0008/ES/Inflamación y enfermedades reumáticas/
dc.relation.urihttps://doi.org/10.1038/TPJ.2015.29
dc.rightsThis version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at Springer Nature Link.
dc.rights.accessRightsopen access
dc.subjectAntirheumatic Agents
dc.subjectArthritis, Rheumatoid
dc.subjectI-kappa B Kinase
dc.subjectInterleukin-10
dc.subjectLeukocyte Common Antigens
dc.subjectTumor Necrosis Factor-alpha
dc.titleReplication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis
dc.typejournal article
dc.type.hasVersionAM
dspace.entity.typePublication
relation.isAuthorOfPublicationf357279a-035a-4279-a553-99cfd79bd2bb
relation.isAuthorOfPublication.latestForDiscoveryf357279a-035a-4279-a553-99cfd79bd2bb

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