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http://hdl.handle.net/2183/41799 In vivo emergence of resistance to ceftazidime/avibactam through modification of chromosomal AmpC β-lactamase in Klebsiella aerogenes
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Rodríguez-Pallares, Salud
Blanco Martín, Tania
Lence, Emilio
Aja-Macaya, Pablo
Sánchez-Peña, Lucía
González-Pinto, Lucía
Rodríguez-Mayo, María
Fernández González, Ana
Galán-Sánchez, Fátima
Beceiro Casas, Alejandro
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Rodríguez-Pallares S, Blanco-Martín T, Lence E, Aja-Macaya P, Sánchez-Peña L, González-Pinto L, Rodríguez-Mayo M, Fernández-González A, Galán-Sánchez F, Beceiro A, González-Bello C, Bou G, Arca-Suárez J. In vivo emergence of resistance to ceftazidime/avibactam through modification of chromosomal AmpC β-lactamase in Klebsiella aerogenes. Antimicrob Agents Chemother. 2024 Dec 5;68(12):e0130724.
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Abstract
[Abstract] We describe the in vivo emergence of resistance to ceftazidime/avibactam via modification of AmpC in a clinical Klebsiella aerogenes isolate during therapy with this combination. Paired ceftazidime/avibactam-susceptible/resistant isolates were obtained before and during ceftazidime/avibactam treatment. Whole genome sequencing revealed a differential mutation in AmpC (R148W) in the ceftazidime/avibactam-resistant isolate. Molecular cloning and structural studies confirmed the impact of this substitution, which affects the architecture of the H10 helix, on the evolved resistant phenotype.
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Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International License (CC-BY 4.0)