In Silico Identification of Common Pre-existing Resistance Mechanisms to EGFR Inhibitors in Colorectal Cancer

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UDC.coleccionInvestigación
UDC.conferenceTitleEACR 2025
UDC.departamentoCiencias da Computación e Tecnoloxías da Información
UDC.grupoInvLaboratorio de Aprendizaxe Automático en Ciencias Vivas (MALL)
dc.contributor.authorMartín-Revuelta, Samuel
dc.contributor.authorFernández-Lozano, Carlos
dc.contributor.authorLiñares Blanco, José
dc.date.accessioned2026-09-03T10:44:11Z
dc.date.available2026-09-03T10:44:11Z
dc.date.issued2025-06
dc.descriptionAbstract do poster presentado en: Annual Congress of the European Association for Cancer Research (EACR 2025), 16–19 June 2025, Lisboa, Portugal. Abstracts: https://febs.onlinelibrary.wiley.com/doi/epdf/10.1002/1878-0261.70070. Póster dispoñible en: https://hdl.handle.net/2183/49142.
dc.description.abstract[Abstract]: This study presents an in silico multi-omic approach combining Non-Negative Matrix Factorization (NMF) and a drug enrichment score to identify pre-existing, shared transcriptomic latent factors driving resistance to EGFR inhibitors in colorectal cancer.
dc.identifier.citationS. Martín Revuelta, C. Fernández-Lozano, and J. Liñares-Blanco, "In Silico Identification of Common Pre-existing Resistance Mechanisms to EGFR Inhibitors in Colorectal Cancer", Abstract EACR25-0278, Molecular Oncology 19 (supl. 1), pp. 354-355, June 2025. ISSN 1878-0261. https://doi.org/10.1002/1878-0261.70070
dc.identifier.doi10.1002/1878-0261.70070
dc.identifier.issn1878-0261
dc.identifier.urihttps://hdl.handle.net/2183/49141
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.relation.hasversionS. Martín Revuelta, C. Fernández-Lozano, and J. Liñares-Blanco, "In Silico Identification of Common Pre-existing Resistance Mechanisms to EGFR Inhibitors in Colorectal Cancer" [poster], Annual Congress of the European Association for Cancer Research (EACR 2025), 16–19 June 2025, Lisboa, Portugal. https://hdl.handle.net/2183/49142.
dc.relation.ispartofhttps://doi.org/10.1002/1878-0261.70070
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectColorectal cancer
dc.subjectEGFR inhibitors
dc.subjectNon-negative matrix factorization
dc.titleIn Silico Identification of Common Pre-existing Resistance Mechanisms to EGFR Inhibitors in Colorectal Cancer
dc.typeconference output
dspace.entity.typePublication
relation.isAuthorOfPublicatione5ddd06a-3e7f-4bf4-9f37-5f1cf3d3430a
relation.isAuthorOfPublicationcf4ecc37-12be-45fc-add3-01c6a7f02630
relation.isAuthorOfPublication.latestForDiscoverye5ddd06a-3e7f-4bf4-9f37-5f1cf3d3430a

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