Food-intake-regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta

Caminos, Jorge Eduardo; Bravo López, Susana Belén; González, Carmen Ruth; Garcés, María Fernanda; Cepeda, Libia Alexandra; González-Almario, Adriana C.; Cordido, Fernando; López, Miguel; Diéguez, Carlos

Food-intake-regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta

UDC.coleccion	Investigación
UDC.departamento	Fisioterapia, Medicina e Ciencias Biomédicas
UDC.grupoInv	Grupo Fisiopatoloxía Endócrina, Nutricional e Médica (FENM)
UDC.grupoInv	Enfermidades Endocrinas, Nutricionais e Metabólicas (INIBIC)
UDC.institutoCentro	INIBIC - Instituto de Investigacións Biomédicas de A Coruña
UDC.journalTitle	Reproductive Biology and Endocrinology
UDC.volume	6
dc.contributor.author	Caminos, Jorge Eduardo
dc.contributor.author	Bravo López, Susana Belén
dc.contributor.author	González, Carmen Ruth
dc.contributor.author	Garcés, María Fernanda
dc.contributor.author	Cepeda, Libia Alexandra
dc.contributor.author	González-Almario, Adriana C.
dc.contributor.author	Cordido, Fernando
dc.contributor.author	López, Miguel
dc.contributor.author	Diéguez, Carlos
dc.date.accessioned	2026-07-07T07:57:09Z
dc.date.available	2026-07-07T07:57:09Z
dc.date.issued	2008-04-02
dc.description.abstract	[Abstract] Background: Neuropeptide Y (NPY), agouti related peptide (AgRP), cocaine and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and energy homeostasis. Recent evidence has demonstrated their expression in rat and human placenta. Methods: In the current study, we have investigated the expression of those neuropeptides in the rat placenta by real-time PCR using a model of maternal food restriction. Results: Our results showed that placental-derived neuropeptides were regulated through pregnancy and following food restriction. Conclusion: These data could indicate that placental-derived neuropeptides represent a local regulatory circuit that may fine-tune control of energy balance during pregnancy.
dc.description.sponsorship	This work has been supported by grants from Xunta de Galicia (ML: GRC2006/66), Fondo Investigationes Sanitarias (ML: PI061700), Ministerio de Educacion y Ciencia (CD: BFU2005), Mútua Madrileña (CD and ML) and European Union (CD: LSHM-CT-2003-503041).
dc.identifier.citation	Caminos JE, Bravo SB, González CR, Garcés MF, Cepeda LA, González AC, Cordido F, López M, Diéguez C. Food-intake-regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta. Reprod Biol Endocrinol. 2008 Apr 2;6:14
dc.identifier.doi	10.1186/1477-7827-6-14
dc.identifier.issn	1477-7827
dc.identifier.uri	https://hdl.handle.net/2183/48792
dc.language.iso	eng
dc.publisher	Springer Nature
dc.relation.projectID	B
dc.relation.uri	https://doi.org/10.1186/1477-7827-6-14
dc.rights	Attribution 4.0 International	en
dc.rights.accessRights	open access
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject	Food Deprivation
dc.subject	Gene Expression Regulation
dc.subject	Hypothalamus
dc.subject	Malnutrition
dc.subject	Neuropeptides
dc.subject	Placenta
dc.subject	Pregnancy, Animal
dc.subject	Rats
dc.title	Food-intake-regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta
dc.type	journal article
dc.type.hasVersion	VoR
dspace.entity.type	Publication
relation.isAuthorOfPublication	df28f954-c072-4ef1-b629-d6af3945bd92
relation.isAuthorOfPublication.latestForDiscovery	df28f954-c072-4ef1-b629-d6af3945bd92