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http://hdl.handle.net/2183/18390 Ghrelin and lipid metabolism: key partners in energy balance
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Vázquez, María J.
Nogueiras, Rubén
Vidal-Puig, Antonio
Diéguez, Carlos
López, Miguel
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Varela L, Vázquez MJ, Cordido F, Nogueiras R, Vidal-Puig A, Diéguez C, López M. Ghrelin and lipid metabolism: key partners in energy balance. J Mol Endocrinol. 2011 Feb 15;46(2):R43-63.
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Abstract
[Abstract] Ghrelin, the endogenous ligand of the GH secretagogue receptor, has a pleiotropic role in the modulation of energy balance. Recent evidence has demonstrated that besides its orexigenic role, ghrelin regulates central and peripheral lipid metabolism through specific control of hypothalamic AMP-activated protein kinase (AMPK), a critical metabolic gauge regulating both cellular and whole-body energy homeostasis. In this review, we summarize the new milestones of ghrelin's actions on energy balance, with particular focus on its molecular interaction with hypothalamic AMPK and fatty acid metabolism. Understanding this new metabolic pathway can provide new therapeutic targets for the treatment of obesity and the metabolic syndrome.
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Disclaimer: this is not the definitive version of record of this article. This manuscript has been accepted for publication in "Journal of Molecular Endocrinology", but the version presented here has not yet been copy-edited, formatted or proofed. Consequently, Bioscientifica acepts no responsability for any errors on omissions it may contain. The definitive version is now freely avaliable at doi 10.1677/JME-10-0068