Screening and validation of novel biomarkers in osteoarticular pathologies by comprehensive combination of protein array technologies

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UDC.coleccionInvestigación
UDC.departamentoFisioterapia, Medicina e Ciencias Biomédicas
UDC.endPage1899
UDC.grupoInvReumatoloxía (INIBIC)
UDC.institutoCentroINIBIC - Instituto de Investigacións Biomédicas de A Coruña
UDC.issue5
UDC.journalTitleJournal of Proteome Research
UDC.startPage1890
UDC.volume16
dc.contributor.authorSierra-Sánchez, Álvaro
dc.contributor.authorGarrido-Martín, Diego
dc.contributor.authorLourido, Lucía
dc.contributor.authorGonzález-González, María
dc.contributor.authorDíez, Paula
dc.contributor.authorRuiz-Romero, Cristina
dc.contributor.authorSjöberg, Ronald
dc.contributor.authorDroste, Conrad
dc.contributor.authorDe Las Rivas, Javier
dc.contributor.authorNilsson, Peter
dc.contributor.authorBlanco García, Francisco J
dc.contributor.authorFuentes, Manuel
dc.date.accessioned2026-04-30T10:13:15Z
dc.date.available2026-04-30T10:13:15Z
dc.date.issued2017-04-05
dc.description.abstract[Abstract] Osteoarthritis (OA) is one of the most prevalent articular diseases. The identification of proteins closely associated with the diagnosis, progression, prognosis, and treatment response is dramatically required for this pathology. In this work, differential serum protein profiles have been identified in OA and rheumatoid arthritis (RA) by antibody arrays containing 151 antibodies against 121 antigens in a cohort of 36 samples. Then the identified differential serum protein profiles have been validated in a larger cohort of 282 samples. The overall immunoreactivity is higher in the pathological situations in comparison with the controls. Several proteins have been identified as biomarker candidates for OA and RA. Most of these biomarker candidates are proteins related to inflammatory response, lipid metabolism, or bone and extracellular matrix formation, degradation, or remodeling.
dc.description.sponsorshipWe gratefully acknowledge financial support from the Carlos III Health Institute of Spain (ISCIII, FIS PI14/01538, PI12/00624, PI12/00329, PI14/01707, CIBER-CB06/01/0040, and RETIC-RIER-RD12/0009/0018), Fondos FEDER (EU), Junta Castilla y León (BIO/SA07/15), and Fundación Solórzano (FS-23-2015). The Proteomics Unit belongs to ProteoRed, PRB2-ISCIII, supported by Grant No. PT13/0001 (ISCIII-Fondos FEDER). P.D. and C.D. are supported by a JCYL-EDU/346/2013 Ph.D. scholarship. The work of D.G.M. was supported by a collaboration scholarship (BOE-A-2014-3844) from the Spanish Ministry of Education, Culture, and Sports (MECD) and awarded in the XIII Certamen Universitario Arquímedes (BOE-A-2014-12688, MECD). We also thank Javier Martín Vallejo and Manuel Muñoz Aguirre for useful discussions and statistical support.
dc.identifier.citationierra-Sánchez Á, Garrido-Martín D, Lourido L, González-González M, Díez P, Ruiz-Romero C, Sjöber R, Droste C, De Las Rivas J, Nilsson P, Blanco F, Fuentes M. Screening and validation of novel biomarkers in osteoarticular pathologies by comprehensive combination of protein array technologies. J Proteome Res. 2017 May 5;16(5):1890-1899.
dc.identifier.doi10.1021/ACS.JPROTEOME.6B00980
dc.identifier.issn1535-3907
dc.identifier.urihttps://hdl.handle.net/2183/48147
dc.language.isoeng
dc.publisherACS Publications
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI14%2F01538/ES/Diseño y desarrollo de estrategias nanoproteomicas para la caracterización de biomarcadores en liquido cefalorraquideo en enfermedad leptomeningea, empleando linfoma non-Hodgkin como modelo/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI12%2F00624/ES/Biología molecular integrativa de hemopatías malignas: análisis bioinformáticos de datos transcriptómicos y proteómicos para identificar genes marcadores, genes causales y redes reguladoras asociadas a subclases patológicas de dos síndromes proliferativos/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI12%2F00329/ES/PROYECTO PROTEOMA HUMANO ESPAÑOL: Aplicacion en Enfermedades Reumatologicas/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI14%2F01707/ES/Validación de biomarcadores proteicos de artrosis mediante proteómica dirigida para el desarrollo de un método de diagnóstico in vitro/
dc.relation.urihttps://doi.org/10.1021/ACS.JPROTEOME.6B00980
dc.rightsThis document is the Accepted Manuscript version of a Published Article that appeared in final form in Journal of Proteome Research, copyright © American Chemical Society.
dc.rights.accessRightsopen access
dc.subjectAntibody arrays
dc.subjectBiomarkers
dc.subjectContact printing
dc.subjectNoncontact printing
dc.subjectOsteoarthritis
dc.subjectRheumatoid arthritis
dc.subjectSerum protein profiles
dc.titleScreening and validation of novel biomarkers in osteoarticular pathologies by comprehensive combination of protein array technologies
dc.typejournal article
dc.type.hasVersionAM
dspace.entity.typePublication
relation.isAuthorOfPublicationf357279a-035a-4279-a553-99cfd79bd2bb
relation.isAuthorOfPublication.latestForDiscoveryf357279a-035a-4279-a553-99cfd79bd2bb

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