Site-Selective C–H Amination of Phenol-Containing Biomolecules

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UDC.coleccionInvestigaciónes_ES
UDC.departamentoQuímicaes_ES
UDC.endPage4387es_ES
UDC.grupoInvQuímica Molecular e de Materiais (QUIMOLMAT)es_ES
UDC.issue23es_ES
UDC.journalTitleOrganic Letterses_ES
UDC.startPage4383es_ES
UDC.volume25es_ES
dc.contributor.authorGirón-Elola, Carlota
dc.contributor.authorSasiain, Ibon
dc.contributor.authorSánchez-Fernández, Rosalía
dc.contributor.authorPazos, Elena
dc.contributor.authorCorrea, Arkaitz
dc.date.accessioned2024-07-01T08:21:15Z
dc.date.available2024-07-01T08:21:15Z
dc.date.issued2023-06-07
dc.description.abstract[Abstract] A C–N bond-forming cross-dehydrogenative coupling of a collection of Tyr-containing peptides and estrogens with heteroarenes is described. This oxidative coupling is distinguished by its scalability, operational simplicity, and air tolerance and enables the appendance of phenothiazines and phenoxazines in phenol-like compounds. When incorporated into a Tb(III) metallopeptide, the Tyr-phenothiazine moiety acts as a sensitizer for the Tb(III) ion, providing a new tool for the design of luminescent probes.es_ES
dc.description.sponsorshipWe are grateful to Ministerio de Ciencia e Innovación (PID2021-122889NB-I00, CTQ2017-89166-R, MCIN/AEI/FEDER, UE), the Consellería de Cultura, Educación e Universidade, Xunta de Galicia (ED431C 2018/39, ED431C 2022/39, and 508/2020), and Basque Government (IT1741-22) for financial support. We thank for technical and human support provided by Central Service of Analysis-SGIker of UPV/EHU and European funding (ERDF and ESF). R.S.F. thanks the Consellería de Cultura, Educación e Universidade, Xunta de Galicia for her PhD fellowship (ED481A-2020/008). E.P. thanks the MCIN/AEI/10.13039/501100011033 and ESF Investing in your future for her RyC contract (RYC2019-027199-I)es_ES
dc.description.sponsorshipXunta de Galicia; ED431C 2018/39es_ES
dc.description.sponsorshipXunta de Galicia; ED431C 2022/39es_ES
dc.description.sponsorshipXunta de Galicia; 508/2020es_ES
dc.description.sponsorshipGobierno Vasco; IT1741-22es_ES
dc.description.sponsorshipXunta de Galicia; ED481A-2020/008es_ES
dc.identifier.citationGirón-Elola, C.; Sasiain, I.; Sánchez-Fernández, R.; Pazos, E.; Correa, A. Site-Selective C–H Amination of Phenol-Containing Biomolecules. Org. Lett. 2023, 25 (23), 4383–4387. https://doi.org/10.1021/acs.orglett.3c01560.es_ES
dc.identifier.doi10.1021/acs.orglett.3c01560
dc.identifier.issn1523-7052
dc.identifier.issn1523-7060
dc.identifier.urihttp://hdl.handle.net/2183/37569
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122889NB-I00/ES/NUEVAS APROXIMACIONES SINTETICAS EN LA FUNCIONALIZACION C-H DE PEPTIDOSes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-89166-R/ES/HERRAMIENTAS PEPTIDICAS PARA APLICACIONES BIOLOGICAS: SENSORES INTELIGENTES PARA ESTUDIAR NITRACION DE PROTEINAS Y NANOMATERIALES CON FUNCIONALIDADES MODULABLESes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RYC2019-027199-I/ESes_ES
dc.relation.urihttps://doi.org/10.1021/acs.orglett.3c01560es_ES
dc.rightsAtribución 3.0 Españaes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.titleSite-Selective C–H Amination of Phenol-Containing Biomoleculeses_ES
dc.typejournal articlees_ES
dspace.entity.typePublication
relation.isAuthorOfPublication2937ed3e-6088-4530-ba68-f72739264fd1
relation.isAuthorOfPublication.latestForDiscovery2937ed3e-6088-4530-ba68-f72739264fd1

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