Unicompartmental versus bicompartmental joint space width measures: which reflect whole joint structural damage better?: data from IMI-APPROACH

Abstract

[Abstract] Objective: To investigate the associations between whole joint cartilage and meniscal morphology on MRI and radiographic joint space width (JSW) measures and in knee osteoarthritis (KOA), to determine whether bicompartmental measures demonstrate stronger associations than unicompartmental ones, and to evaluate their correlations with Kellgren and Lawrence grading.

Design: A cross-sectional analysis of baseline radiographs and MRIs from 262 KOA participants in the prospective, multicenter IMI-APPROACH cohort was conducted. Radiographic measures included minimum joint space width (mJSW), fixed location JSW (JSW(x)), mean JSW, and joint line convergence angle (JLCA), assessed using fully automated software. JSW was evaluated both unicompartmentally and bicompartmentally. Cartilage morphology, full-thickness cartilage loss, meniscal extrusion, tears, and maceration were assessed using the semi-quantitative MRI Osteoarthritis Knee Score to summarize whole-joint cartilage and meniscal morphology. Associations of radiographic measures with MRI outcomes were assessed using multivariable linear regression; Spearman correlations with Kellgren and Lawrence (KL) were also evaluated.

Results: MRI-defined meniscal maceration was associated with unicompartmental and bicompartmental JSW measures. Full-thickness cartilage loss was associated with unicompartmental (95% CI [-0.16;-0.02]) and bicompartmental mJSW (95% CI [-0.14;-0.02]), and JLCA (95% CI [0.04;0.22]). Models explained 32-39% of variance for unicompartmental and 23-45% for bicompartmental measures (R²). Bicompartmental measures showed stronger correlations with KL grading than unicompartmental measures (95% CI: -0.31 to -0.02).

Conclusions: Associations between whole-joint cartilage and meniscal degeneration are similar for uni- and bicompartmental JSW, with bicompartmental JSW showing stronger correlations with KL grades. These findings support including both compartments in radiographic assessment to improve structural evaluation in KOA.