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https://hdl.handle.net/2183/48533

Differential roles of antimicrobials in the acquisition of drug resistance through activation of the SOS response in Acinetobacter baumannii

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URI: https://hdl.handle.net/2183/48533
DOI: 10.1128/AAC.04918-14

Publication date

2015-06-12

Authors

Jara, Luis M.
Cortés, Pilar
Barbé, Jordi
Aranda, Jesús

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Bibliographic citation

Jara LM, Cortés P, Bou G, Barbé J, Aranda J. Differential roles of antimicrobials in the acquisition of drug resistance through activation of the SOS response in Acinetobacter baumannii. Antimicrob Agents Chemother. 2015 Jul;59(7):4318-20.

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Abstract

[Abstract] The effect of antimicrobials on SOS-mediated mutagenesis induction depends on the bacterial species and the antimicrobial group. In this work, we studied the effect of different families of antimicrobial agents used in clinical therapy against Acinetobacter baumannii in the induction of mutagenesis in this multiresistant Gram-negative pathogen. The data showed that ciprofloxacin and tetracycline induce SOS-mediated mutagenesis, whereas colistin and meropenem, which are extensively used in clinical therapy, do not.

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Keywords

Acinetobacter baumannii Anti-Bacterial Agents Drug Resistance, Bacterial SOS Response, Genetics

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https://doi.org/10.1128/AAC.04918-14

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Attribution 4.0 International

Except where otherwise noted, this item's license is described as Attribution 4.0 International