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http://hdl.handle.net/2183/41407 Sellar and Perisellar Meningiomas: Effects on Pituitary Function in a Spanish Cohort Observational Study
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Guerrero-Pérez, Fernando
Biagetti, Betina
Paja Fano, Miguel
Menéndez-Torre, Edelmiro Luis
Rivero, Gonzalo
Dios Fuentes, Elena
Hanzu, Felicia Alexandra
Martín Rojas-Marcos, Patricia
Irigaray Echarri, Ana
Moure Rodríguez, María Dolores
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Guerrero-Pérez F, Biagetti B, Paja-Fano M, Menéndez-Torre EL, Rivero G, Dios E, Hanzu FA, Martín Rojas-Marcos P, Irigaray A, Moure Rodríguez MD, García-Centeno R, González Fernández L, Enseñat J, Mora M, Villar-Taibo R, Ortiz García IM, Araujo-Castro M, Gándara C, Ollero García MD, Tenorio-Jiménez C, Novo-Rodríguez C, Civantos S, Simó-Servat A, Aulinas A, Asla Q, Cordido F, Novoa-Testa I, Xifra G, Ayala-Conte M, Zamarrón Á, García Berrocal MI, Iglesias P; Neuroendocrinology Task Force of Spanish Society of Endocrinology and Nutrition. Sellar and perisellar meningiomas: effects on pituitary function in a spanish cohort observational study. Pituitary. 2024 Dec 28;28(1):12.
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Abstract
[Abstract]
Purpose: Studies focused on the effects of sellar and/or perisellar (S/PS) meningiomas on pituitary function are scarce. The primary objective of the present study was to determinate the effects that S/PS meningiomas and their treatments have on pituitary function. Also, we described the clinical characteristics and therapeutic outcomes of the cohort of adult Spanish patients.
Methods: A multicenter and retrospective study of patients with S/PS meningiomas attended in 20 tertiary Spanish centers.
Results: 165 patients, 123 (74.5%) females, with median age of 61.4 [51-71] years were analyzed. At presentation, 115 (69.7%) had visual disturbance, 62 (37.6%) headache, 46 (27.9%) cranial nerve palsy and 34 (26.2%) hypopituitarism. Median tumor diameter was 29.1 [22-35.5] mm and cavernous sinus infiltration was detected in 95 (59%). As initial treatment, 128 (77.6%) underwent surgery, 25 (15.2%) received radiotherapy and 12 (7.3%) were clinically and radiologically monitored. Among operated patients, gross total resection (GTR) was achieved in 44 (34.4%), whereas in 84 (65.6%) the tumor was incompletely removed. Overall median follow-up was 5.7 [2.9-9.2] years. After treatments, hypopituitarism was present in 86 (53.4%) patients at the last evaluation, and it was associated with surgery extension (subtotal or GTR) but not with tumor subtype, type of radiotherapy or radiation dose received.
Conclusions: S/PS meningiomas affect the pituitary function in 25% of the cases. However, after the implementation of treatments, hypopituitarism prevails in more than 50% of the cases. They are relatively large tumors and GTR is achieved in one third of the cases in whom hypopituitarism is more prevalent.
Description
Observational study
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This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at Spirnger Nature Link web page.