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http://hdl.handle.net/2183/19647 High relaxivity Mn2+-based MRI contrast agents
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Regueiro-Figueroa, Martín
Rolla, Gabriele A.
Botta, Mauro
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Regueiro-Figueroa, M., Rolla, G. A., Esteban-Gómez, D., de Blas, A., Rodríguez-Blas, T., Botta, M. and Platas-Iglesias, C. (2014), High Relaxivity Mn2+-Based MRI Contrast Agents. Chem. Eur. J., 20: 17300–17305.
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Abstract
[Abstract] Stable Mn2+ mono- and binuclear complexes containing pentadentate 6,6′-((methylazanediyl)bis(methylene)) dipicolinic acid coordinating units give remarkably high relaxivities due to the presence of two inner-sphere water molecules. The mononuclear derivative binds human serum albumin (HSA) with an association constant of 3372 M−1, which results in the replacement of the coordinated water molecules by donor atoms of protein residues. The dinuclear analogue also binds HSA while leaving one of the Mn2+ centres exposed to the solvent with two coordinated water molecules. Thus, this complex shows remarkably high relaxivities upon protein binding (39.0 mM−1 s−1 per Mn, at 20 MHz and 37 °C).
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This is the peer reviewed version of the following article: Regueiro-Figueroa, M., Rolla, G. A., Esteban-Gómez, D., de Blas, A., Rodríguez-Blas, T., Botta, M. and Platas-Iglesias, C. (2014), High Relaxivity Mn2+-Based MRI Contrast Agents. Chem. Eur. J., 20: 17300–17305, which has been published in final form at https://doi.org/10.1002/chem.201404673. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.