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https://hdl.handle.net/2183/47571 Prevalence and evolution of hypertension in a large Iberian cohort of patients with acromegaly
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Araújo-Castro, Marta
García-Centeno, Rogelio
González, Laura
Lacerda Nobre, Ema
Severino, Mariana de Griné
Goi, Jessica
Pérez Pena, Marta María
Menéndez Torre, Edelmiro
Lozano Aida, Claudia
Novoa-Testa, Iria
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Araujo-Castro M, García-Centeno R, González L, Lacerda Nobre E, de Griné Severino M, Goi J, Pérez Pena MM, Menéndez Torre E, Lozano Aida C, Novoa-Testa I, Cordido F, Sánchón R, Guerrero-Pérez F, Oliva Rodríguez R, Rodríguez-Jiménez B, Ollero García MD, Irigaray Echarri A, Simó-Servat A, Moure Rodríguez MD, Novo-Rodríguez C, Calatayud M, Villar-Taibo R, Bernabéu I, Tenorio-Jimenéz C, González Molero I, Iglesias P, Blanco C, Vidal-Ostos De Lara F, Aulinas A, Asla Roca Q, Paja Fano M, Rivera Martínez A, Cardoso LM, Marques P, Giustina A, Marazuela M, Puig-Domingo M, Biagetti B. Prevalence and evolution of hypertension in a large Iberian cohort of patients with acromegaly. Pituitary. 2025 Oct 25;28(6):119.
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Abstract
[Abstract] Purpose: To analyze the prevalence of hypertension in patients with acromegaly and assess the impact of acromegaly treatment on blood pressure (BP) outcomes.
Methods: Retrospective multicenter study of 434 patients with acromegaly surveilled at 25 tertiary hospitals in Spain and Portugal. The cohort was divided into two subgroups: patients with (n = 209) and without (n = 225) hypertension at the time of acromegaly diagnosis.
Results: Of the 434 patients, 209 (48.2%) had hypertension at the time of acromegaly diagnosis. Patients with acromegaly and hypertension were older and had a higher prevalence of cardiovascular disease and risk factors. A significant BP improvement was observed 3 months after pituitary surgery, with a marked reduction of the SBP (ΔSBP - 5.0mmHg, 95%CI -2.37 to -7.61) and DBP (ΔDBP - 2.2mmHg, 95% CI -0.66 to -3.75). Over a median follow-up of 8.4 years [IQR 4.8-12.8], 16% (n = 35/218) of initially normotensive patients developed hypertension, while 14.1% (n = 27/192) of hypertensive patients achieved hypertension remission. Hypertension remission was more likely in patients taking fewer antihypertensive drugs and with higher IGF1 levels at diagnosis, and in those who had a greater decrease in GH and IGF-1 after surgery.
Conclusion: At the time of acromegaly diagnosis up to 50% of patients have hypertension, and around 15% of them experience hypertension remission after pituitary surgery. The probability of remission is higher in patients with milder baseline hypertension and higher IGF-1 levels and in those achieving a greater postoperative decrease of GH and IGF-1.
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Multicenter study
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This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at Spirnger Nature Link.