Emergence of KPC-producing Pseudomonas aeruginosa in Spain: insights into an outbreak and resistance to the novel carbapenem/β-lactamase inhibitor combinations imipenem/relebactam and meropenem/vaborbactam

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UDC.coleccionInvestigación
UDC.departamentoFisioterapia, Medicina e Ciencias Biomédicas
UDC.grupoInvInvestigación en Microbiología (INIBIC)
UDC.institutoCentroINIBIC - Instituto de Investigacións Biomédicas de A Coruña
UDC.issue5
UDC.journalTitleAntimicrobial Agents and Chemotherapy
UDC.volume70
dc.contributor.authorPérez-Rodríguez, Gloria
dc.contributor.authorAja-Macaya, Pablo
dc.contributor.authorGonzález-Pinto, Lucía
dc.contributor.authorTaltavull, Biel
dc.contributor.authorTarriño-León, María
dc.contributor.authorGallardo-García, María del Mar
dc.contributor.authorBlanco Martín, Tania
dc.contributor.authorRodríguez-Pallares, Salud
dc.contributor.authorSánchez-Peña, Lucía
dc.contributor.authorMoscoso, Miriam
dc.contributor.authorBeceiro Casas, Alejandro
dc.contributor.authorOliver, Antonio
dc.contributor.authorBou, Germán
dc.contributor.authorArca-Suárez, Jorge
dc.date.accessioned2026-05-25T10:45:54Z
dc.date.available2026-05-25T10:45:54Z
dc.date.issued2026-03-27
dc.description.abstract[Abstract] We report an outbreak of KPC-producing Pseudomonas aeruginosa in Spain, involving four patients and an environmental isolate recovered from a hospital sink. All isolates belonged to clone ST253 and exhibited difficult-to-treat resistance, including resistance to imipenem/relebactam and meropenem/vaborbactam. Genomic analysis confirmed a plasmid-encoded blaKPC-2 and OprD deficiency. Functional assays demonstrated synergy between KPC-2 production and porin loss on resistance to carbapenem/β-lactamase inhibitors. The findings highlight the clinical threat posed by KPC-producing P. aeruginosa.
dc.description.sponsorshipThis study was supported by the Instituto de Salud Carlos III (ISCIII), through projects PI22/01212, PI23/00851, PI24/00010, and PI24/00920, and co-funded by the European Union. The research was also funded by Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC, CB21/13/00055, and CB21/13/00099). Funding was also provided by Axencia Galega de Innovación (GAIN), Consellería de Innovación and Consellería de Economía, Emprego e Industria, and Xunta de Galicia (IN607D 2021/012 to A.B., IN607A 2024/009 to G.B., and IN607D 2024/008 to J.A.-S.). G.P.-R. was financially supported by GAIN-Xunta de Galicia (IN606A 2025/020). L.G.-P. was financially supported by the ISCIII PFIS program (FI23/00074). T.B.-M. was financially supported by the ISCIII Río Hortega program (CM23/00095). S.R.-P. was financially supported by the ISCIII Río Hortega program (CM23/00104). L.S.-P. was financially supported by GAIN-Xunta de Galicia (IN606A 2024/022). M.M. was financially supported by Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC). J.A.-S. was financially supported by the ISCIII Juan Rodés program (JR21/00026). This work was also supported by the Fundación Pública Galega de Investigación Biomédica INIBIC, which provided financial support for the final publication of the article.
dc.identifier.citationPérez-Rodríguez G, Aja-Macaya P, González-Pinto L, Taltavull B, Tarriño-León M, Gallardo-García MdM, Blanco-Martín T, Rodríguez-Pallares S, Sánchez-Peña L, Moscoso M, Beceiro A, Oliver A, Bou G, Arca-Suárez J. Emergence of KPC-producing Pseudomonas aeruginosa in Spain: insights into an outbreak and resistance to the novel carbapenem/β-lactamase inhibitor combinations imipenem/relebactam and meropenem/vaborbactam. Antimicrob Agents Chemother. 2026 May 6;70(5):e0165725.
dc.identifier.doi10.1128/AAC.01657-25
dc.identifier.issn1098-6596
dc.identifier.urihttps://hdl.handle.net/2183/48365
dc.language.isoeng
dc.publisherAmerican Society for Microbiology
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/PI22%2F01212/ES/Inhibidores de carbapenemasas: actividad frente a Enterobacterales productores de carbapenemasas, mecanismos e impacto en la evolución de la resistencia antimicrobiana (PROTECT)/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/PI24%2F00010/ES/Optimización del diagnóstico, tratamiento y control de las infecciones por Pseudomonas aeruginosa a través de la monitorización de la dinámica del resistoma a escala de paciente y de nación completa./
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/PI24%2F00920/ES/Vacunas versátiles basadas en ARN para combatir las infecciones causadas por cepas multirresistentes de Pseudomonas aeruginosa/
dc.relation.projectIDXunta de Galicia; IN607D 2021/012
dc.relation.projectIDXunta de Galicia; IN607A 2024/009
dc.relation.projectIDXunta de Galicia; IN607D 2024/008
dc.relation.urihttps://doi.org/10.1128/AAC.01657-25
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectKPC
dc.subjectPseudomonas aeruginosa
dc.subjectCarbapenem
dc.subjectCarbapenemase
dc.subjectImipenem/relebactam
dc.subjectMeropenem/vaborbactam
dc.subjectMutational mechanisms
dc.subjectβ-lactam resistance
dc.subjectβ-lactamase
dc.subjectβ-lactamase inhibitor
dc.titleEmergence of KPC-producing Pseudomonas aeruginosa in Spain: insights into an outbreak and resistance to the novel carbapenem/β-lactamase inhibitor combinations imipenem/relebactam and meropenem/vaborbactam
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublication909e08d1-6ed1-4b99-9e9e-c64eb72e7dea
relation.isAuthorOfPublication.latestForDiscovery909e08d1-6ed1-4b99-9e9e-c64eb72e7dea

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