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Mostrando ítems 11-20 de 37
Mitochondria and Mitophagy: Biosensors for Cartilage Degradation and Osteoarthritis
(Elsevier, 2018-05-29)
Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts: a meta-analysis and functional study
(BMJ, 2016-12-05)
[Abstract] Objective To evaluate the influence of the mitochondrial DNA (mtDNA) haplogroups in the risk of incident knee osteoarthritis (OA) and to explain the functional consequences of this association to identify potential ...
Mitochondrial genetics and epigenetics in osteoarthritis
(Frontiers, 2020-01-17)
[Abstract] During recent years, the significant influence of mitochondria on osteoarthritis (OA), the most common joint disease, has been consistently demonstrated. Not only mitochondrial dysfunction but also mitochondrial ...
Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative
(BMJ, 2019-08-30)
[Abstract] Objective To find autoantibodies (AAbs) in serum that could be useful to predict incidence of radiographic knee osteoarthritis (KOA).
Design A Nucleic-acid Programmable Protein Arrays (NAPPA) platform was ...
Mitochondrial DNA in Osteoarthritis Disease
(Springer, 2020-09-25)
[Abstract]
Osteoarthritis (OA) is the most prevalent chronic joint disease, and we actually know that the activation of maladaptive responses to injury, including pro-inflammatory pathways, leads to the loss of normal ...
What did we learn from 'omics' studies in osteoarthritis
(Wolters Kluwer, 2018-01-01)
[Abstract] Purpose of review: 'Omics' technologies developed for the massive analysis of the major biologically relevant molecules (genes, proteins, metabolites) have been applied to the study of osteoarthritis (OA) for ...
Generating Rho-0 cells using mesenchymal stem cell lines
(PLoS, 2016-10-20)
[Abstract] Introduction, The generation of Rho-0 cells requires the use of an immortalization process, or tumor cell selection, followed by culture in the presence of ethidium bromide (EtBr), incurring the drawbacks its ...
Mitochondrial DNA (mtDNA) haplogroups J and H are differentially associated with the methylation status of articular cartilage: potential role in apoptosis and metabolic and developmental processes
(Wiley, 2019-02-12)
[Abstract] Objective. To analyze the influence of mitochondrial genome variation on the DNA methylome of articular cartilage.
Methods. DNA methylation profiling was performed using data deposited in the NCBI Gene ...
Specific premature epigenetic aging of cartilage in osteoarthritis
(Impact Journals, 2016-09-28)
[Abstract] Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, ...
Mitochondrial DNA (mtDNA) haplogroups influence the progression of knee osteoarthritis: data from the Osteoarthritis Initiative (OAI)
(PLoS, 2014-11-12)
[Abstract] OBJECTIVE:
To evaluate the influence of the mtDNA haplogroups on knee osteoarthritis progression in Osteoarthritis Initiative (OAI) participants through longitudinal data from radiographs and magnetic resonance ...