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Mitochondrial DNA haplogroups associated with MRI-detected structural damage in early knee osteoarthritis
(Elsevier, 2018-07-20)
[Abstract] Objective: Magnetic resonance imaging (MRI)-detected structural features are associated with increased risk of radiographic osteoarthritis (ROA). Specific mitochondrial DNA (mtDNA) haplogroups have been associated ...
Mitochondrial haplogroups H and J: risk and protective factors for ischemic cardiomyopathy
(PLoS, 2012-08-28)
[Abstract] Background. Since mitochondria are the principal source of reactive oxygen species (ROS), these organelles may play an important role in ischemic cardiomyopathy (IC) development. The mitochondrial genome may ...
Plasma mitochondrial DNA levels are inversely associated with HIV-RNA levels and directly with CD4 counts: potential role as a biomarker of HIV replication
(Oxford, 2017-08-31)
[Abstract] Objectives. To evaluate plasma mitochondrial DNA (mtDNA) levels among HIV-infected patients and its potential role as a biomarker of residual viral replication.
Methods. HIV-infected patients on follow-up at a ...
Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis
(BioMed Central, 2011-11-22)
[Abstract] Background: Oxidative stress play a main role in the initiation and progression of the OA disease and leads to the degeneration of mitochondria. To prevent this, the chondrocytes possess a well-coordinated ...
Leukocyte telomere length in patients with radiographic knee osteoarthritis
(Wiley, 2019-11-29)
[Abstract] Relative mean telomere sequence amount was determined by quantitative PCR (qPCR) of peripheral blood leukocyte (PBL) samples obtained at recruitment (n = 310) from individuals from the Osteoarthritis (OA) ...
Is It Time for Epigenetics in Osteoarthritis?
(Wiley, 2014-05-16)
[Abstract] DNA methylation is an epigenetic mechanism of reversible gene regulation which typically results in gene silencing upon hypermethylation in high CpG density regions of promoters (termed CpG islands), and increased ...
Mitochondria and Mitophagy: Biosensors for Cartilage Degradation and Osteoarthritis
(Elsevier, 2018-05-29)
Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts: a meta-analysis and functional study
(BMJ, 2016-12-05)
[Abstract] Objective To evaluate the influence of the mitochondrial DNA (mtDNA) haplogroups in the risk of incident knee osteoarthritis (OA) and to explain the functional consequences of this association to identify potential ...
Mitochondrial genetics and epigenetics in osteoarthritis
(Frontiers, 2020-01-17)
[Abstract] During recent years, the significant influence of mitochondria on osteoarthritis (OA), the most common joint disease, has been consistently demonstrated. Not only mitochondrial dysfunction but also mitochondrial ...
Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative
(BMJ, 2019-08-30)
[Abstract] Objective To find autoantibodies (AAbs) in serum that could be useful to predict incidence of radiographic knee osteoarthritis (KOA).
Design A Nucleic-acid Programmable Protein Arrays (NAPPA) platform was ...