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Evaluation of 12 GWAS-drawn SNPs as biomarkers of rheumatoid arthritis response to TNF inhibitors. A potential SNP association with response to etanercept

Ferreiro-Iglesias, Aida; Montes, Ariana; Pérez-Pampin, Eva; Cañete, Juan D.; Raya, Enrique; Magro-Checa, César; Vasilopoulos, Yiannis; Cáliz, Rafael; Ferrer, Miguel Ángel; Joven, Beatriz; Carreira, Patricia; Balsa, Alejandro; Pascual-Salcedo, Dora; Blanco García, Francisco J; Moreno-Ramos, Manuel J.; Manrique-Arija, Sara; Ordoñez, María del Carmen; Alegre-Sancho, Juan J.; Narváez, Javier; Navarro-Sarabia, Federico; Moreira, Viriginia; Valor, Lara; García-Portales, Rosa; Márquez, Ana; Gómez-Reino, Juan J.; Martín, Javier; González, Antonio (PLoS, 2019-02-28)

[Abstract] Research in rheumatoid arthritis (RA) is increasingly focused on the discovery of biomarkers that could enable personalized treatments. The genetic biomarkers associated with the response to TNF inhibitors (TNFi) ...

Rheumatoid arthritis response to treatment across IgG1 allotype – anti-TNF incompatibility: a case-only study

Montes, Adriana; Pérez-Pampin, Eva; Navarro-Sarabia, Federico; Moreira, Virginia; Rodríguez de la Serna, Arturo; Magallanes, Berta; Vasilopoulos, Yiannis; Sarafidou, Theologia; Fernández.Nebro, Antonio; Ordóñez, María del Carmen; Narváez, Javier; Cañete, Juan D.; Márquez, Ana; Pascual-Salcedo, Dora; Joven, Beatriz; Carreira, Patricia; Moreno-Ramos, Manuel J.; Cáliz, Rafael; Ferrer, Miguel Ángel; García-Portales, Rosa; Blanco García, Francisco J; Magro, César; Raya, Enrique; Valor, Lara; Alegre-Sancho, Juan J.; Balsa, Alejandro; Martín, Javier; Plant, Darren; Isaacs, John; Morgan, Ann W.; Barton, Anne; Wilson, Anthony G. (BioMed Central, 2015-03-18)

[Abstract] INTRODUCTION: We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of ...

A single nucleotide polymorphism in the Il17ra promoter is associated with functional severity of ankylosing spondylitis

Vidal-Castiñeira, José Ramón; López-Vázquez, Antonio; Díaz-Peña, Alberto; Díaz-Bulnes, Paula; Martínez-Camblor, Pablo; Coto, Eliecer; Coto-Segura, Pablo; Bruges-Armas, Jacome; PInto, José Antonio; Blanco García, Francisco J; Sánchez, Alejandra; Mulero, Juan; Queiro, Rubén; López-Larrea, Carlos (PLoS, 2016-07-14)

[Abstract] The aim of this study was to identify new genetic variants associated with the severity of ankylosing spondylitis (AS). We sequenced the exome of eight patients diagnosed with AS, selected on the basis of the ...

Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case–control study

Ferreiro-Iglesias, Aida; Calaza, Manuel; Pérez-Pampin, Eva; López-Longo, J.; Marenco, José L.; Blanco García, Francisco J; Narváez, Javier; Navarro, Federico; Cañete, Juan D.; Rodríguez de la Serna, Arturo; González-Álvaro, Isidoro; Herrero-Beaumont, Gabriel; Pablos, José L.; Balsa, Alejandro; Fernández-Gutiérrez, Benjamín; Cáliz, Rafael; Gómez-Reino, Juan J.; González, Antonio (BioMed Central, 2014-09-27)

[Abstract] INTRODUCTION: Approximately 100 loci have been definitively associated with rheumatoid arthritis (RA) susceptibility. However, they explain only a fraction of RA heritability. Interactions between polymorphisms ...

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

Cortes, Adrian; Pulit, Sara L.; Leo, Paul J.; Pointon, Jenny J.; Robinson, Philip C.; Weisman, Michael H.; Ward, Michael; Gensler, Lianne S.; Zhou, Xiaodong; Garchon, Henri-Jean; Chiocchia, Gilles; Nossent, Johannes; Lie, Benedicte A.; Øystein, Førre; Tuomilehto, Jaako; Laiho, Kari; Bradbury, Linda A.; Elewaut, Dirk; Burgos-Vargas, Rubén; Stebbings, Simon; Appleton, Louise; Farrah, Claire; Lau, Jonathan; Haroon, Nigil; Mulero, Juan; Blanco García, Francisco J; González-Gay, Miguel Á.; López-Larrea, Carlos; Bowness, Paul; Gaffney, Karl; Gaston, Hill; Gladman, Dafna D.; Rahman, Proton; Maksymowych, Walter P.; Crusius, Bart A.; van der Horst-Buinsma, Irene E.; Valle-Oñate, Raphael; Romero-Sánchez, Consuelo; Hansen, Inger Myrnes; Pimentel-Santos, Fernando M.; Inman, Robert D.; Martín, Javier; Breban, Maxime; Wordsworth, Bryan Paul; Reveille, John D.; Evans, David M.; Bakker, Paul I.W. de; Brown, Matthew A. (Nature, 2015-05-21)

[Abstract] Article Open Access Published: 21 May 2015 Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1 Adrian Cortes, Sara L. Pulit, Paul J. ...

Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis

López-Lasanta, María; Juliá, Antonio; Maymó, Joan; Fernández-Gutiérrez, Benjamín; Ureña-Garnica, Inmaculada; Blanco García, Francisco J; Cañete, Juan D.; Alperi-López, Mercedes; Olivé, Alex; Corominas, Héctor; Tornero, Jesús; Erra, Alba; Almirall, Miriam; Palau, Nuria; Ortiz, Ana; Ávila, Gabriela; Rodríguez-Rodríguez, Luis; Alonso, Arnald; Tortosa, Raül; González-Álvaro, Isidoro; Marsal, Sara (BMC, 2015-09-04)

[Abstract] Introduction. Interleukin-6 (IL-6) cytokine signaling is key in Rheumatoid Arthritis (RA) pathophysiology. Blocking IL-6 receptor (IL6R) has proven to be a highly effective treatment to prevent joint damage. ...

Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus

Alonso-Pérez, Elisa; Suárez-Gestal, Marian; Calaza, Manuel; Blanco García, Francisco J; Suárez, Ana; Santos, María José; Papasteriades, Chryssa; Carreira, Patricia; Pullmann, Rudolf; Ordi-Ros, Josep; Marchini, Maurizio; Skopouli, Fotini N.; Bijl, Marc; Barrizone, Nadia; Sebastiani, Gian Domenico; Migliaresi, Sergio; Witte, Torsten; Lauwerys, Bernard R.; Kovacs, Attila; Ruzickova, Sarka; Gómez-Reino, Juan J.; González, Antonio (BioMed Central, 2014-06-19)

[Abstract] INTRODUCTION: We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was ...