Browsing Investigación (FCS) by Research Group "Grupo de Investigación en Reumatoloxía e Saúde (GIR-S)"

Now showing items 1-20 of 175

    • 3, 3′, 5-triiodo-L-thyronine increases in vitro chondrogenesis of mesenchymal stem cells from human umbilical cord stroma through SRC2 

      Fernández-Pernas, Pablo; Fafián Labora, Juan Antonio; Lesende-Rodríguez, Iván; Mateos, Jesús; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Arufe, M.C. (Wiley, 2016-07-08)
      [Abstract] Our group focuses on the study of mesenchymal stem cells (MSCs) from human umbilical cord stroma or Warthońs jelly and their directed differentiation toward chondrocyte-like cells capable of regenerating damaged ...

    • A clinical model including protein biomarkers predicts radiographic knee osteoarthritis: a prospective study using data from the Osteoarthritis Initiative 

      Lourido Salas, Lucía María; Balboa-Barreiro, Vanesa; Ruiz-Romero, Cristina; Rego-Pérez, Ignacio; Camacho Encina, María; Paz González, Rocío; Calamia, Valentina; Oreiro, Natividad; Nilsson, Peter; Blanco García, Francisco J (Elsevier, 2021-04-30)

    • A combined transcriptomic and genomic analysis identifies a gene signature associated with the response to anti-TNF therapy in rheumatoid arthritis 

      Aterido, Adriá; Cañete, Juan D.; Tornero, Jesús; Blanco García, Francisco J; Fernández-Gutiérrez, Benjamín; Pérez, Carolina; Alperi-López, Mercedes; Olivé, Alex; Corominas, Héctor; Martínez-Taboada, Víctor; González, Isidoro; Fernández-Nebro, Antonio; Erra, Alba; López-Lasanta, María; López-Corbeto, Mireia; Palau, Núria; Juliá, Antonio; Marsal, Sara (Frontiers, 2019-07-02)
      [Abstract] Background: Rheumatoid arthritis (RA) is the most frequent autoimmune disease involving the joints. Although anti-TNF therapies have proven effective in the management of RA, approximately one third of patients ...

    • A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis 

      Torices, Silvia; Juliá, Antonio; Muñoz, Pedro; Varela, Ignacio; Balsa, Alejandro; Marsal, Sara; Fernández-Nebro, Antonio; Blanco García, Francisco J; López-Hoyos, Marcos; Martínez-Taboada, Víctor; Fernández-Luna, José L. (Springer, 2016-10-04)
      [Abstract] Background. Toll-like receptor (TLR) family members are key players in inflammation. TLR10 has been poorly studied in chronic inflammatory disorders, and its clinical relevance in rheumatoid arthritis (RA) is ...

    • A Meta-Analysis of Genome-Wide Association Studies Identifies Novel Variants Associated with Osteoarthritis of the Hip 

      Evangelou, Evangelos; Kerkhof, Hanneke J.; Styrkarsdottir, Unnur; Ntzani, Evangelia E.; Bos, Steffan D.; Esko, Tonu; Evans, Daniel S.; Metrustry, Sarah; Panoutsopoulou, Kalliope; Ramos, Yolande F. M.; Thorleifsson, Gudmar; Tsilidis, Konstantinos K.; Arden, Nigel; Aslam, Nadim; Bellamy, Nicholas; Birrell, Fraser; Blanco García, Francisco J; Carr, Andrew; Chapman, Kay; Day-Williams, Aaaron G.; Deloukas, Panos; Doherty, Michael; Engström, Gunnar; Helgadottir, Hafdis T.; Hofman, Albert; Ingvarsson, Thorvaldur; Jonsson, Helgi; Keis, Aime; Keurentjes, J. Christiaan; Kloppenburg, Margreet; Lind, Penelope A.; McCaskie, Andrew; Martin, Nicholas G.; Milani, Lili; Montgomery, Grant W.; Nelissen, Rob G.H.H.; Nevitt, Michael C.; Nilsson, Peter M.; Ollier, William E.R.; Parimi, Neeta; Rai, Ashok; Ralston, Stuart H.; Reed, Mike R.; Riancho, José A.; Rivadeneira, Fernando; Rodríguez-Fontenla, Cristina; Southam, Lorraine; Thorsteindottir, Unnur; Tsezou, Aspasia; Wallis, Gillian A.; Wilkinson, J. Mark; González, Antonio; Lane, Nancy E.; Lohmander, L. Stefan; Loughlin, John; Metspalu, Andres; Uitterlinden, André G.; Jonsdottir, Ingileif; Stefansson, Kari; Slagboom, P. Eline; Zeggini, Eleftheria; Meulebelt, Ingrid; Ionnidis, John P.A.; Spector, Tim D.; van Meurs, Joyce B.J.; Valdes, Ana M. (BMJ, 2013-08-29)
      [Abstract] OBJECTIVES: Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies ...

    • A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine 

      Calamia, Valentina; Mateos, Jesús; Fernández-Puente, Patricia; Lourido Salas, Lucía María; Rocha Loureda, Beatriz; Fernández-Costa, Carolina; Montell, Eulalia; Vergés, Josep; Ruiz-Romero, Cristina; Blanco García, Francisco J (Nature, 2014-06-10)
      [Abstract] Osteoarthritis (OA) is the most common age-related rheumatic disease. Chondrocytes play a primary role in mediating cartilage destruction and extracellular matrix (ECM) breakdown, which are main features of the ...

    • A single nucleotide polymorphism in the Il17ra promoter is associated with functional severity of ankylosing spondylitis 

      Vidal-Castiñeira, José Ramón; López-Vázquez, Antonio; Díaz-Peña, Alberto; Díaz-Bulnes, Paula; Martínez-Camblor, Pablo; Coto, Eliecer; Coto-Segura, Pablo; Bruges-Armas, Jacome; PInto, José Antonio; Blanco García, Francisco J; Sánchez, Alejandra; Mulero, Juan; Queiro, Rubén; López-Larrea, Carlos (PLoS, 2016-07-14)
      [Abstract] The aim of this study was to identify new genetic variants associated with the severity of ankylosing spondylitis (AS). We sequenced the exome of eight patients diagnosed with AS, selected on the basis of the ...

    • Alternative protocols to induce chondrogenic differentiation: transforming growth factor-β superfamily 

      Cicione, Claudia; Muiños Gómez, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Springer, 2014-09-10)
      [Abstract] Mesenchymal stem cells (MSCs) are an accepted candidate for cell-based therapy of multiple diseases. The interest in MSCs and their possible application in cell therapy have resulted in a better understanding ...

    • Amentadione from the alga cystoseira usneoides as a novel osteoarthritis protective agent in an ex vivo co-culture OA model 

      Araújo, Nuna; Viegas, Carla S.B.; Zubía, Eva; Magalhaes, Joana; Ramos, Acácio; Carvalho, Maria M.; Cruz, Henrique; Sousa, Joao Paulo; Blanco García, Francisco J; Vermeer, Cees; Simes, Dina C. (MDPI, 2020-12-07)
      [Abstract] Osteoarthritis (OA) remains a prevalent chronic disease without effective prevention and treatment. Amentadione (YP), a meroditerpenoid purified from the alga Cystoseira usneoides, has demonstrated anti-inflammatory ...

    • Analyses of the genetic polymorphisms rs3740199 and rs1871054 of the ADAM12 gene and the alleles at the rs2073508 loci of the TGFB1 gene and their contribution to susceptibility to primary knee osteoarthritis 

      Aguilar Muñiz, Lizette Sarai; González Galarza, Faviel Francisco; Arguello Astorga, Rafael; Prieto Hinojosa, Adria Imelda; Hernández Terán, Fernando; Méndez Hernández, Alejandra; Espino Silva, Perla Karina; Blanco García, Francisco J; Arellano Pérez Vertti, Rubén Daniel (Mary Ann Liebert, 2020-06)
      [Abstract] Aims: To analyze the association of polymorphisms in the ADAM12 (rs3740199 and rs1871054) and TGFB1 (rs2073508) genes with knee osteoarthritis (KOA) in a population from northern Mexico. Methods: A total of 296 ...

    • Analysis of endogenous peptides released from osteoarthritic articular cartilage unravels novel pathogenic markers 

      Fernández-Puente, Patricia; González-Rodríguez, Lucía; Calamia, Valentina; Picchi, Florencia; Lourido Salas, Lucía María; Camacho Encina, María; Oreiro, Natividad; Rocha Loureda, Beatriz; Paz González, Rocío; Marina, Anabel; García, Carlos; Blanco García, Francisco J; Ruiz-Romero, Cristina (American Society for Biochemistry and Molecular Biology (ASBMB), 2019-07-27)
      [Abstract] Osteoarthritis (OA) is a pathology characterized by the loss of articular cartilage. In this study, we performed a peptidomic strategy to identify endogenous peptides (neopeptides) that are released from human ...

    • Analysis of the chondrogenic potential and secretome of mesenchymal stem cells derived from human umbilical cord stroma 

      Arufe, M.C.; Fuente, Alexandre de la; Mateos, Jesús; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Mary Ann Liebert, 2011-06-28)
      [Abstract] Mesenchymal stem cells (MSCs) from umbilical cord stroma were isolated by plastic adherence and characterized by flow cytometry, looking for cells positive for OCT3/4 and SSEA-4 as well as the classic MSC markers ...

    • Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis and current skin involvement: a phase III, randomised, controlled trial (PALACE 3) 

      Edwards, Christopher J.; Blanco García, Francisco J; Crowley, Jeffrey; Birbara, Charles A.; Jaworski, Janusz; Aelion, Jacob; Stevens, Randall M.; Vessey, Adele; Zhan, Xiaojiang; Bird, Paul (BMJ, 2016-01-20)
      [Abstract] Objective. To evaluate apremilast treatment in patients with active psoriatic arthritis, including current skin involvement, despite prior therapy with conventional disease-modifying antirheumatic drugs and/or ...

    • La artrosis y la ateroesclerosis de la articulación 

      Blanco García, Francisco J (Elsevier, 2018-09-08)

    • Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies 

      Rodríguez-Fontenla, Cristina; Calaza, Manuel; Evangelou, Evangelos; Valdés, Ana M.; Arden, Nigel; Blanco García, Francisco J; Carr, Andrew; Chapman, Kay; Deloukas, Panos; Doherty, Michael; Esko, Tonu; Garcés Aletá, Carlos M.; Gómez-Reino Carnota, Juan J.; Helgadottir, Hafids; Hofman, Albert; Jonsdottir, Ingilef; Kerkhof, Henneke J.M.; Kloppenburg, Margreet; McCaskie, Andrew; Ntzani, Evangelia E.; Ollier, William E.R.; Oreiro, Natividad; Panoutsopoulo, Kalliope; Ralston, Stuart H.; Ramos, Yolande F. M.; Riancho, José A.; Rivadeneira, Fernando; Slagboom, Eline; Styrkarsdottir, Unnur; Thorsteindottir, Unnur; Thorleifsson, Gudmar; Tsezou, Aspasia; Uitterlinden, André G.; Wallis, Gillian A.; Wilkinson, J. Mark; Zhai, Yanyan; Felson, David T.; Ioannidis, John P.A.; Loughlin, John; Metspalu, Andres; Meulenbelt, Ingrid; Stefansson, Kari; van Meurs, Joyce B.; Zeggini, Eleftheria; Spector, Timothy D.; González, Antonio (Wiley, 2013-12-10)
      [Abstract] Objective: To assess candidate genes for association with osteoarthritis (OA) and identify promising genetic factors and, secondarily, to assess the candidate gene approach in OA. Methods: A total of 199 ...

    • Association of accelerated dynamics of telomere sequence loss in peripheral blood leukocytes with incident knee osteoarthritis in Osteoarthritis Initiative cohort 

      Guillén, Rebeca; Otero, Fátima; Mosquera, Alejandro; Vázquez-Mosquera, María E.; Rego-Pérez, Ignacio; Blanco García, Francisco J; Fernández, José Luis (Nature, 2021-08-05)
      [Abstract] Osteoarthritis (OA) is a chronic degenerative joint disease, being the main cause of laboral inability. Decreased telomere size in peripheral blood leukocytes (PBL) has been correlated with age-related pathologies, ...

    • Association of serum anti-centromere protein F antibodies with clinical response to infliximab in patients with rheumatoid arthritis: a prospective study 

      Lourido Salas, Lucía María; Ruiz-Romero, Cristina; Picchi, Florencia; Diz-Rosales, Naomi; Vilaboa Galán, Sergio; Fernández-López, Carlos; Pinto-Tasende, José A.; Pérez-Pampin, Eva; Regueiro, Cristina; Mera-Varela, Antonio; González, Antonio; Hambardzumyan, Karen; Saevarsdottir, Saedis; Nilsson, Peter; Blanco García, Francisco J (Elsevier, 2020-06-30)
      [Abstract] Background: One-third of rheumatoid arthritis (RA) patients demonstrate no clinical improvement after receiving tumor necrosis factor inhibitors (TNFi). The presence of serum autoantibodies is a hallmark in RA ...

    • Association of the serological status of rheumatoid arthritis patients with two circulating protein biomarkers: a useful tool for precision medicine strategies 

      Ruiz-Romero, Cristina; Fernández-Puente, Patricia; González, Lucía; Illiano, Anna; Lourido, Lucía; Paz, Rocío; Quaranta, Patricia; Pérez-Pampín, Eva; González, Antonio; Blanco García, Francisco J; Calamia, Valentina (Frontiers, 2022-10-28)
      [Abstract] Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints and presence of systemic autoantibodies, with a great clinical and molecular heterogeneity. Rheumatoid Factor ...

    • Autophagy activation by resveratrol reduces severity of experimental rheumatoid arthritis 

      Fernández-Rodríguez, Jennifer Adriana; Almonte-Becerril, Maylin; Ramil-Gómez, Olalla; Hermida-Carballo, Laura; Viñas-Diz, Susana; Vela-Anero, Á.; Concha, Ángel; Camacho Encina, María; Blanco García, Francisco J; López-Armada, María José (Wiley, 2020-11-12)

    • Baseline clinical characteristics of predicted structural and pain progressors in the IMI-APPROACH knee OA cohort 

      van Helvoort, Eefje M.; Ladel, Christoph H.; Mastbergen, Simon; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Bacardit, Jaume; Widera, Pawel; Welsing, Paco M.J.; Lafeber, Floris (BMJ, 2021-08-23)
      [Abstract] Objectives: To describe the relations between baseline clinical characteristics of the Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) participants and their predicted ...