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AHL-lactonase Expression in Three Marine Emerging Pathogenic Vibrio spp. Reduces Virulence and Mortality in Brine Shrimp (Artemia salina) and Manila Clam (Venerupis philippinarum)
dc.contributor.author | Torres, Marta | |
dc.contributor.author | Reina, José Carlos | |
dc.contributor.author | Fuentes-Monteverde, Juan Carlos | |
dc.contributor.author | Fernández, Gerardo | |
dc.contributor.author | Rodríguez, Jaime | |
dc.contributor.author | Jiménez, Carlos | |
dc.contributor.author | Llamas, Inmaculada | |
dc.date.accessioned | 2024-06-27T11:39:14Z | |
dc.date.available | 2024-06-27T11:39:14Z | |
dc.date.issued | 2018-04-17 | |
dc.identifier.citation | Torres M, Reina JC, Fuentes-Monteverde JC, Fernández G, Rodríguez J, Jiménez C, et al. (2018) AHL-lactonase expression in three marine emerging pathogenic Vibrio spp. reduces virulence and mortality in brine shrimp (Artemia salina) and Manila clam (Venerupis philippinarum). PLoS ONE 13(4): e0195176. https://doi.org/10.1371/journal.pone.0195176 | es_ES |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/2183/37490 | |
dc.description.abstract | [Abstract] Bacterial infectious diseases produced by Vibrio are the main cause of economic losses in aquaculture. During recent years it has been shown that the expression of virulence genes in some Vibrio species is controlled by a population-density dependent gene-expression mechanism known as quorum sensing (QS), which is mediated by the diffusion of signal molecules such as N-acylhomoserine lactones (AHLs). QS disruption, especially the enzymatic degradation of signalling molecules, known as quorum quenching (QQ), is one of the novel therapeutic strategies for the treatment of bacterial infections. In this study, we present the detection of AHLs in 34 marine Vibrionaceae strains. Three aquaculture-related pathogenic Vibrio strains, V. mediterranei VibC-Oc-097, V. owensii VibC-Oc-106 and V. coralliilyticus VibC-Oc-193 were selected for further studies based on their virulence and high production of AHLs. This is the first report where the signal molecules have been characterized in these emerging marine pathogens and correlated to the expression of virulence factors. Moreover, the results of AHL inactivation in the three selected strains have been confirmed in vivo against brine shrimps (Artemia salina) and Manila clams (Venerupis philippinarum). This research contributes to the development of future therapies based on AHL disruption, the most promising alternatives for fighting infectious diseases in aquaculture. | es_ES |
dc.description.sponsorship | This research was supported in part by grants from the Ministerio de Economía y Competitividad (Spain) (http://www.mineco.gob.es/portal/site/mineco/idi) (AGL2012-39274-C02-02; AGL2015-68806-R; AGL2015-63740-C2-2-R). José Carlos Reina is supported by a FPU fellowship from the Ministerio de Educación, Cultura y Deporte (Spain) (https://www.mecd.gob.es/portada-mecd/) (FPU15-01717) and a Initiation to Research fellowship for Master Students (2016) from the University of Granada (Spain) (http://www.ugr.es). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | PLOS | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Nacional de I+D+i 2008-2011/AGL2012-39274-C02-02/ES/ANALISIS ESTRUCTURAL DE LOS SIDEROFOROS PRODUCIDOS POR LAS DOS SUBESPECIES DE PHOTOBACTERIUM DAMSELAE: DESARROLLO DE NUEVOS ANTIBACTERIANOS Y VACUNAS | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-68806-R/ES/ALTERNATIVA ECOLOGICA Y SOSTENIBLE PARA COMBATIR LA VIBRIOSIS EN ACUICULTURA: QUORUN SENSING VERSUS QUORUM QUENCHING | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-63740-C2-2-R/ES/DESARROLLO DE APLICACIONES DE LOS SIDEROFOROS Y SUS RECEPTORES DE MEMBRANA PARA EL DISEÑO DE NUEVOS METODOS DE CONTROL DE INFECCIONES BACTERIANAS EN ACUICULTURA | es_ES |
dc.relation | info:eu-repo/grantAgreement/MECD/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FPU15%2F01717/ES/ | es_ES |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0195176 | es_ES |
dc.rights | Atribución 4.0 Internacional | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | AHL-lactonase Expression in Three Marine Emerging Pathogenic Vibrio spp. Reduces Virulence and Mortality in Brine Shrimp (Artemia salina) and Manila Clam (Venerupis philippinarum) | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | PLOS ONE | es_ES |
UDC.volume | 13 | es_ES |
UDC.issue | 4 | es_ES |
UDC.startPage | e0195176 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0195176 |
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