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Thermosensitive Hydrogel Based on PEO–PPO–PEO Poloxamers for a Controlled In Situ Release of Recombinant Adeno-Associated Viral Vectors for Effective Gene Therapy of Cartilage Defects

Madry, Henning; Rey-Rico, Ana; Venkatesan, Jagadeesh Kumar; Schmitt, Gertrud; Speicher-Mentges, Susanne; Cucchiarini, Magali; Goebel, Lars; Zurakowski, David; Laschke, Matthias W.; Cai, Xiaoyu; Menger, Michael D.; Gao, Liang; Müller-Brandt, Kathrin (WILEY-VCH, 2020)

[Abstract] Advanced biomaterial-guided delivery of gene vectors is an emerging and highly attractive therapeutic solution for targeted articular cartilage repair, allowing for a controlled and minimally invasive delivery ...

Non-viral Gene Delivery to Human Mesenchymal Stem Cells: A Practical Guide Towards Cell Engineering

López-Seijas, Junquera; Rey-Rico, Ana; Carballo-Pedrares, Natalia; Ponti, Federica; Miranda-Balbuena, Diego; Bono, Nina; Candiani, Gabriele (BioMed Central, 2023)

[Abstract] In recent decades, human mesenchymal stem cells (hMSCs) have gained momentum in the field of cell therapy for treating cartilage and bone injuries. Despite the tri-lineage multipotency, proliferative properties, ...