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dc.contributor.authorSanegre, Sabina
dc.contributor.authorEritja, Núria
dc.contributor.authorAndrea, Carlos de
dc.contributor.authorDíaz-Martín, Juan
dc.contributor.authorDíaz-Lagares, Angel
dc.contributor.authorJácome, M. A.
dc.contributor.authorSalguero Aranda, Carmen
dc.contributor.authorGarcía-Ros, David
dc.contributor.authorDavidson, Ben
dc.contributor.authorLópez-López, Rafael
dc.contributor.authorMelero, Ignacio
dc.contributor.authorNavarro, Samuel
dc.contributor.authorRamón y Cajal, Santiago
dc.contributor.authorAlava, Enrique de
dc.contributor.authorMatias-Guiu, Xavier
dc.contributor.authorNoguera, Rosa
dc.date.accessioned2021-09-10T16:38:01Z
dc.date.available2021-09-10T16:38:01Z
dc.date.issued2021
dc.identifier.citationSanegre S, Eritja N, de Andrea C, Diaz-Martin J, Diaz-Lagares Á, Jácome MA, Salguero-Aranda C, García Ros D, Davidson B, Lopez R, Melero I, Navarro S, Ramon y Cajal S, de Alava E, Matias-Guiu X and Noguera R (2021) Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma. Front. Cell Dev. Biol. 9:670185. doi: 10.3389/fcell.2021.670185es_ES
dc.identifier.urihttp://hdl.handle.net/2183/28451
dc.description.abstract[Abstract] The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. Herein we focus on the invasive tumor front, making an in-depth characterization of reticular fiber scaffolding, infiltrating immune cells, gene expression, and epigenetic profiles of classified aggressive primary uterine adenocarcinomas (24 patients) and leiomyosarcomas (11 patients). Sections of formalin-fixed samples before and after microdissection were scanned and studied. Reticular fiber architecture and immune cell infiltration were analyzed by automatized algorithms in colocalized regions of interest. Despite morphometric resemblance between reticular fibers and high presence of macrophages, we found some variance in other immune cell populations and distinctive gene expression and cell adhesion-related methylation signatures. Although no evident overall differences in immune response were detected at the gene expression and methylation level, impaired antimicrobial humoral response might be involved in uterine leiomyosarcoma spread. Similarities found at the invasive tumor front of uterine adenocarcinomas and leiomyosarcomas could facilitate the use of common biomarkers and therapies. Furthermore, molecular and architectural characterization of the invasive front of uterine malignancies may provide additional prognostic information beyond established prognostic factors.es_ES
dc.description.sponsorshipThis research was supported by grants from the ISCIII and ERDF (PI17/01558 and PI20/01107), by the CIBERONC (contracts CB16/12/00484, CB16/12/0328, CB16/12/00363, CB16/12/00364, CB16/12/00481, and CB16/12/00231) and Grupos Coordinados Estables from the Asociación Española Contra el Cáncer (AECC). ÁD-L was funded by a contract “Juan Rodés” from the ISCIII (JR17/00016).es_ES
dc.language.isoenges_ES
dc.publisherFrontierses_ES
dc.relationinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI17%2F01558/ES/IDENTIFICACION Y VALIDACION DE NUEVAS TERAPIAS, MODELOS PRECLINICOS Y MARCADORES DE RESPUESTA/
dc.relationinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F01107/ES/NEUROBLASTOMA: ESTRATEGIAS MECANOTERAPEUTICAS BASADAS EN MODELOS 3D Y TUMORES DERIVADOS DE PACIENTES CON MICROAMBIENTE RICO EN VITRONECTINA/
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CB16%2F12%2F00484/ES/CANCER
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CB16%2F12%2F00328/ES/CANCER
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CB16%2F12%2F00363/ES/CANCER
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CB16%2F12%2F00364/ES/CANCER
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CB16%2F12%2F00481/ES/CANCER
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CB16%2F12%2F00231/ES/CANCER
dc.relationinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/JR17%2F00016/ES/
dc.relation.urihttps://doi.org/10.3389/fcell.2021.670185es_ES
dc.rightsAttribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectTumor-host interfacees_ES
dc.subjectTumor microenvironmentes_ES
dc.subjectExtracellular matrixes_ES
dc.subjectReticular fiberses_ES
dc.subjectImmune cellses_ES
dc.subjectGene expressiones_ES
dc.subjectEpigenetic profileses_ES
dc.titleCharacterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcomaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleFrontiers in Cell and Developmental Biologyes_ES
UDC.volume9es_ES
UDC.startPage670185es_ES
dc.identifier.doi10.3389/fcell.2021.670185


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