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Gene variant space for biosensor-based dynamic regulation
dc.contributor.author | Camarena, María | |
dc.contributor.author | Boada, Yadira | |
dc.contributor.author | Picó, Jesús | |
dc.contributor.author | Carbonell, Pablo | |
dc.date.accessioned | 2021-08-26T09:45:05Z | |
dc.date.available | 2021-08-26T09:45:05Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Camarena, M., Boada, Y., Picó, J., Carbonell, P. Gene variant space for biosensor-based dynamic regulation. En XLII Jornadas de Automática: libro de actas. Castelló, 1-3 de septiembre de 2021 (pp. 485-491). DOI capítulo: https://doi.org/10.17979/spudc.9788497498043.485 DOI libro: https://doi.org/10.17979/spudc.9788497498043 | es_ES |
dc.identifier.isbn | 978-84-9749-804-3 | |
dc.identifier.uri | http://hdl.handle.net/2183/28367 | |
dc.description.abstract | [Abstract] Inside a cell, protein, production and biosensor pathways can be genetically engineered within a dynamic regulation architecture that provides robustness to cell factories. Here we investigated how the selection of gene variants and their associated expression efficiency and kinetic parameters can lead to a wide diversity of dynamic responses in terms of protein or metabolite production. Results show that there is a trade-off between gene expression efficiency and pathway performance, and it can be eventually related to the evolutionary fingerprint of each gene variant. Therefore, the organism source of gene variants is a factor that needs to be considered in the design of dynamic regulation for genetic circuits. | es_ES |
dc.description.sponsorship | Ministerio de Economía y Empresa; DPI2017-82896-C2-1-R | es_ES |
dc.description.sponsorship | Ministerio de Ciencia e Innovación; PID2020-117271RB-C21 | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | Universidade da Coruña, Servizo de Publicacións | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/814408 | es_ES |
dc.relation.uri | https://doi.org/10.17979/spudc.9788497498043.485 | es_ES |
dc.rights | Atribución-NoComercial-CompartirIgual 4.0 Internacional https://creativecommons.org/licenses/by-nc-sa/4.0/deed.es | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/es/ | * |
dc.subject | Dynamic regulation | es_ES |
dc.subject | Biosensors | es_ES |
dc.subject | Cell factories | es_ES |
dc.subject | Biomanufacturing | es_ES |
dc.title | Gene variant space for biosensor-based dynamic regulation | es_ES |
dc.type | info:eu-repo/semantics/conferenceObject | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.startPage | 485 | es_ES |
UDC.endPage | 498 | es_ES |
dc.identifier.doi | https://doi.org/10.17979/spudc.9788497498043.485 | |
UDC.conferenceTitle | XLII Jornadas de Automática | es_ES |