Show simple item record

dc.contributor.authorRegueiro-Figueroa, Martín
dc.contributor.authorNonat, Aline
dc.contributor.authorRolla, Gabriele A.
dc.contributor.authorEsteban-Gómez, David
dc.contributor.authorBlas, Andrés de
dc.contributor.authorRodríguez-Blas, Teresa
dc.contributor.authorCharbonnière, Loïc J.
dc.contributor.authorBotta, Mauro
dc.contributor.authorPlatas-Iglesias, Carlos
dc.date.accessioned2018-11-26T12:39:28Z
dc.date.available2018-11-26T12:39:28Z
dc.date.issued2013-08-26
dc.identifier.citationRegueiro‐Figueroa, M. , Nonat, A. , Rolla, G. A., Esteban‐Gómez, D. , de Blas, A. , Rodríguez‐Blas, T. , Charbonnière, L. J., Botta, M. and Platas‐Iglesias, C. (2013), Self‐Aggregated Dinuclear Lanthanide(III) Complexes as Potential Bimodal Probes for Magnetic Resonance and Optical Imaging. Chem. Eur. J., 19: 11696–11706.es_ES
dc.identifier.issn0947-6539
dc.identifier.issn1521-3765
dc.identifier.urihttp://hdl.handle.net/2183/21355
dc.description.abstract[Abstract] Homodinuclear lanthanide complexes (Ln=La, Eu, Gd, Tb, Yb and Lu) derived from a bis‐macrocyclic ligand featuring two 2,2′,2′′‐(1,4,7,10‐tetraazacyclododecane‐1,4,7 triyl)triacetic acid chelating sites linked by a 2,6‐bis(pyrazol‐1‐yl)pyridine spacer (H2L3) were prepared and characterized. Luminescence lifetime measurements recorded on solutions of the EuIII and TbIII complexes indicate the presence of one inner‐sphere water molecule coordinated to each metal ion in these complexes. The overall luminescence quantum yields were determined (∅H2O=0.01 for [Eu2(L3)] and 0.50 for [Tb2(L3)] in 0.01 MTRIS/HCl, pH 7.4; TRIS=tris(hydroxymethyl)aminomethane), pointing to an effective sensitization of the metal ion by the bispyrazolylpyridyl unit of the ligand, especially with Tb. The nuclear magnetic relaxation dispersion (NMRD) profiles recorded for [Gd2(L3)] are characteristic of slowly tumbling systems, showing a low‐field plateau and a broad maximum around 30 MHz. This suggests the occurrence of aggregation of the complexes giving rise to slowly rotating species. A similar behavior is observed for the analogous GdIII complex containing a 4,4′ dimethyl‐2,2′‐bipyridyl spacer ([Gd2(L1)]). The relaxivity of [Gd2(L3)] recorded at 0.5 T and 298 K (pH 6.9) amounts to 13.7 mM−1 s−1. The formation of aggregates has been confirmed by dynamic light scattering (DLS) experiments, which provided mean particle sizes of 114 and 38 nm for [Gd2(L1)] and [Gd2(L3)], respectively. TEM images of [Gd2(L3)] indicate the formation of nearly spherical nanosized aggregates with a mean diameter of about 41 nm, together with some nonspherical particles with larger size.es_ES
dc.description.sponsorshipMinisterio de Educación y Ciencia; CTQ2009‐10721es_ES
dc.description.sponsorshipXunta de Galicia; IN845B‐2010/063es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relation.urihttps://doi.org/10.1002/chem.201301231es_ES
dc.rightsThis is the peer reviewed version of the following article: Regueiro‐Figueroa, M. , Nonat, A. , Rolla, G. A., Esteban‐Gómez, D. , de Blas, A. , Rodríguez‐Blas, T. , Charbonnière, L. J., Botta, M. and Platas‐Iglesias, C. (2013), Self‐Aggregated Dinuclear Lanthanide(III) Complexes as Potential Bimodal Probes for Magnetic Resonance and Optical Imaging. Chem. Eur. J., 19: 11696–11706, which has been published in final form at https://doi.org/10.1002/chem.201301231. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.es_ES
dc.subjectEuropiumes_ES
dc.subjectGadoliniumes_ES
dc.subjectLanthanideses_ES
dc.subjectLuminescencees_ES
dc.subjectMagnetic resonance imaginges_ES
dc.titleSelf‐aggregated dinuclear lanthanide(III) complexes as potential bimodal probes for magnetic resonance and optical imaginges_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleChemistry - A European Journales_ES
UDC.volume19es_ES
UDC.issue35es_ES
UDC.startPage11696es_ES
UDC.endPage11706es_ES


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record