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dc.contributor.authorCarreira-Barral, Israel
dc.contributor.authorFernández-Pérez, María-Isabel
dc.contributor.authorMato-Iglesias, Marta
dc.contributor.authorBlas, Andrés de
dc.contributor.authorPlatas-Iglesias, Carlos
dc.contributor.authorEsteban-Gómez, David
dc.date.accessioned2018-06-13T13:03:02Z
dc.date.available2018-06-13T13:03:02Z
dc.date.issued2018
dc.identifier.citationCarreira-Barral, I.; Fernández-Pérez, I.; Mato-Iglesias, M.; de Blas, A.; Platas-Iglesias, C.; Esteban-Gómez, D. Recognition of AMP, ADP and ATP through Cooperative Binding by Cu(II) and Zn(II) Complexes Containing Urea and/or Phenylboronic—Acid Moieties. Molecules 2018, 23, 479.es_ES
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/2183/20811
dc.description.abstract[Abstract] We report a series of Cu(II) and Zn(II) complexes with different ligands containing a dipicolyl unit functionalized with urea groups that may contain or not a phenylboronic acid function. These complexes were designed for the recognition of phosphorylated anions through coordination to themetal ion reinforced by hydrogen bonds involving the anion and NHgroups of urea. The complexes were isolated and several adducts with pyrophosphate were characterized using X-ray diffraction measurements. Coordination of one of the urea nitrogen atoms to themetal ion promoted the hydrolysis of the ligands containing 1,3-diphenylurea units, while ligands bearing 1-ethyl-3-phenylurea groups did not hydrolyze significantly at room temperature. Spectrophotometric titrations, combined with 1H and 31P NMR studies, were used in investigating the binding of phosphate, pyrophosphate (PPi), and nucleoside 50-polyphosphates (AMP, ADP, ATP, CMP, and UMP). The association constants determined in aqueous solution (pH 7.0, 0.1MMOPS) point to a stronger association with PPi, ADP, and ATP as compared with the anions containing a single phosphate unit. The [CuL4]2+ complex shows important selectivity for pyrophosphate (PPi) over ADP and ATP.es_ES
dc.description.sponsorshipGalicia. Consellería de Cultura, Educación e Ordenación Universitaria; EM 2012/088es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.urihttps://doi.org/10.3390/molecules23020479es_ES
dc.rightsAtribución 3.0 Españaes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subjectMolecular sensorses_ES
dc.subjectMetal complexeses_ES
dc.subjectCooperative bindinges_ES
dc.subjectMultitopic receptores_ES
dc.subjectHydrogen bondinges_ES
dc.subjectUrea groupes_ES
dc.subjectPhenylboronic moietyes_ES
dc.titleRecognition of AMP, ADP and ATP through cooperative binding by Cu(II) and Zn(II) complexes containing urea and/or phenylboronic acid moietieses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleMoleculeses_ES
UDC.volume23es_ES
UDC.issue2es_ES
UDC.startPage479es_ES


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