| dc.contributor.author | Varela, Luis | |
| dc.contributor.author | Vázquez, María J. | |
| dc.contributor.author | Cordido, Fernando | |
| dc.contributor.author | Nogueiras, Rubén | |
| dc.contributor.author | Vidal-Puig, Antonio | |
| dc.contributor.author | Diéguez, Carlos | |
| dc.contributor.author | López, Miguel | |
| dc.date.accessioned | 2017-04-07T08:00:42Z | |
| dc.date.available | 2017-04-07T08:00:42Z | |
| dc.date.issued | 2011-04-01 | |
| dc.identifier.citation | Varela L, Vázquez MJ, Cordido F, Nogueiras R, Vidal-Puig A, Diéguez C, López M. Ghrelin and lipid metabolism: key partners in energy balance. J Mol Endocrinol. 2011 Feb 15;46(2):R43-63. | es_ES |
| dc.identifier.issn | 0952-5041 | |
| dc.identifier.issn | 1479-6813 | |
| dc.identifier.uri | http://hdl.handle.net/2183/18390 | |
| dc.description | Disclaimer: this is not the definitive version of record of this article. This manuscript has been accepted for publication in "Journal of Molecular Endocrinology", but the version presented here has not yet been copy-edited, formatted or proofed. Consequently, Bioscientifica acepts no responsability for any errors on omissions it may contain. The definitive version is now freely avaliable at doi 10.1677/JME-10-0068 | |
| dc.description.abstract | [Abstract] Ghrelin, the endogenous ligand of the GH secretagogue receptor, has a pleiotropic role in the modulation of energy balance. Recent evidence has demonstrated that besides its orexigenic role, ghrelin regulates central and peripheral lipid metabolism through specific control of hypothalamic AMP-activated protein kinase (AMPK), a critical metabolic gauge regulating both cellular and whole-body energy homeostasis. In this review, we summarize the new milestones of ghrelin's actions on energy balance, with particular focus on its molecular interaction with hypothalamic AMPK and fatty acid metabolism. Understanding this new metabolic pathway can provide new therapeutic targets for the treatment of obesity and the metabolic syndrome. | es_ES |
| dc.description.sponsorship | European Commission; FP7/2007–2013 no. 245009 | es_ES |
| dc.description.sponsorship | European Commission; FP7/2007–2013; nº 018734 | es_ES |
| dc.description.sponsorship | Xunta de Gailcia; PS07/12 | es_ES |
| dc.description.sponsorship | Xunta de Gailcia; PGIDIT06PXIB208063PR | es_ES |
| dc.description.sponsorship | Xunta de Gailcia; 10PXIB208164PR | es_ES |
| dc.description.sponsorship | Instituto de Salud Carlos III; PI051024 | es_ES |
| dc.description.sponsorship | Instituto de Salud Carlos III; PI070413 | es_ES |
| dc.description.sponsorship | info:eu-repo/grantAgreement/MICINN/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PS09%2F01880/ES/ACCIONES DE LAS OREXINAS Y LA HORMONA CONCENTRADORA DE MELANINA SOBRE EL METABOLISMO LIPIDICO Y DE LA GLUCOSA, UN NUEVO MECANISMO NEUROENDOCRINO DE REGULACION DEL BALANCE ENERGETICO | es_ES |
| dc.description.sponsorship | info:eu-repo/grantAgreement/MICINN/Programa Nacional de Contratación e Incorporación/RYC-2008-02219/ES | es_ES |
| dc.description.sponsorship | España. Ministerio de Educacion y Ciencia; BFU2008 | es_ES |
| dc.description.sponsorship | info:eu-repo/grantAgreement/MEC/RYC-2007-00211/ES/ | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | Bioscientifica para Society for Endocrinoloogy | es_ES |
| dc.relation.uri | http://dx.doi.org/10.1677/JME-10-0068 | es_ES |
| dc.title | Ghrelin and lipid metabolism: key partners in energy balance | es_ES |
| dc.type | journal article | es_ES |
| dc.rights.accessRights | open access | es_ES |
| UDC.journalTitle | Journal of Molecular Endocrinology | es_ES |
| UDC.volume | 46 | es_ES |
| UDC.startPage | R43 | es_ES |
| UDC.endPage | R63 | es_ES |
| UDC.coleccion | Investigación | es_ES |
| UDC.departamento | Fisioterapia, Medicina e Ciencias Biomédicas | es_ES |
| UDC.grupoInv | Grupo Fisiopatoloxía Endócrina, Nutricional e Médica (FENM) | es_ES |
