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dc.contributor.authorRegueiro-Figueroa, Martín
dc.contributor.authorGündüz, Serhat
dc.contributor.authorPatinec, Véronique
dc.contributor.authorLogothetis, Nikos K.
dc.contributor.authorEsteban-Gómez, David
dc.contributor.authorTripier, Raphaël
dc.contributor.authorAngelovski, Goran
dc.contributor.authorPlatas-Iglesias, Carlos
dc.date.accessioned2017-03-31T09:31:56Z
dc.date.available2017-03-31T09:31:56Z
dc.date.issued2015-10-15
dc.identifier.citationGd3+-Based Magnetic Resonance Imaging Contrast Agent Responsive to Zn2+. Martín Regueiro-Figueroa, Serhat Gündüz, Véronique Patinec, Nikos K. Logothetis, David Esteban-Gómez, Raphaël Tripier, Goran Angelovski, and Carlos Platas-Iglesias. Inorganic Chemistry 2015 54 (21), 10342-10350 DOI: 10.1021/acs.inorgchem.5b01719es_ES
dc.identifier.issn0020-1669
dc.identifier.issn1520-510X
dc.identifier.urihttp://hdl.handle.net/2183/18350
dc.description.abstract[Abstract] We report the heteroditopic ligand H5L, which contains a DO3A unit for Gd3+ complexation connected to an NO2A moiety through a N-propylacetamide linker. The synthesis of the ligand followed a convergent route that involved the preparation of 1,4-bis(tert-butoxycarbonylmethyl)-1,4,7-triazacyclononane following the orthoamide strategy. The luminescence lifetimes of the Tb(5D4) excited state measured for the TbL complex point to the absence of coordinated water molecules. Density functional theory calculations and 1H NMR studies indicate that the EuL complex presents a square antiprismatic coordination in aqueous solution, where eight coordination is provided by the seven donor atoms of the DO3A unit and the amide oxygen atom of the N-propylacetamide linker. Addition of Zn2+ to aqueous solutions of the TbL complex provokes a decrease of the emission intensity as the emission lifetime becomes shorter, which is a consequence of the coordination of a water molecule to the Tb3+ ion upon Zn2+binding to the NO2A moiety. The relaxivity of the GdL complex recorded at 7 T (25 °C) increases by almost 150% in the presence of 1 equiv of Zn2+, while Ca2+ and Mg2+ induced very small relaxivity changes. In vitro magnetic resonance imaging experiments confirmed the ability of GdL to provide response to the presence of Zn2+.es_ES
dc.description.sponsorshipMinisterio de Economía y Competitividad; CTQ2013-43243-Pes_ES
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.relation.urihttps://doi.org/10.1021/acs.inorgchem.5b01719es_ES
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in "Inorganic Chemistry", copyright © American Chemical Society after peer review and technical editing by the publisher.es_ES
dc.subjectContrast agentses_ES
dc.subjectCoordination compoundses_ES
dc.subjectGadoliniumes_ES
dc.subjectLanthanideses_ES
dc.subjectNMR imaginges_ES
dc.titleGd3+-based magnetic resonance imaging contrast agent responsive to Zn2+es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleInorganic Chemistryes_ES
UDC.volume54es_ES
UDC.issue21es_ES
UDC.startPage10342es_ES
UDC.endPage10350es_ES


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