• Factors associated with therapeutic response in acromegaly diagnosed in the elderly in Spain 

      Biagetti, Betina; Iglesias, Pedro; Villar-Taibo, Rocío; Moure, María-Dolores; Paja, Miguel; Araújo-Castro, Marta; Ares, Jessica; Álvarez-Escola, Cristina; Vicente, Almudena; Álvarez Guivernau, Élia; Novoa-Testa, Iria; Guerrero Pérez, Fernando; Cámara, Rosa; Lecumberri, Beatriz; García Gómez, Carlos; Bernabéu, Ignacio; Manjón, Laura; Gaztambide, Sonia; Cordido, Fernando; Webb, Susan; Webb, Susan M.; Menéndez-Torre, Edelmiro Luis; Díez, Juan J.; Simó, Rafael; Puig-Domingo, Manel (Frontiers, 2022-09-16)
      [Abstract] Context: Some reports suggest that acromegaly in elderly patients has a more benign clinical behavior and could have a better response to first-generation long-acting somatostatin receptor ligands (SRL). However, ...
    • FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle 

      Varela-Rodríguez, Bárbara María; Pena-Bello, Lara; Juiz-Valiña, Paula; Vidal Bretal, Beatriz; Cordido, Fernando; Sangiao-Alvarellos, Susana (Nature, 2016-07-19)
      [Abstract] Irisin is processed from fibronectin type III domain-containing protein 5 (FNDC5). However, a controversy exists concerning irisin origin, regulation and function. To elucidate the relationship between serum ...
    • Getting the right patient on the right renal replacement therapy 

      Pérez-Fontán, Miguel; Rodríguez-Carmona, Ana; López-Muñiz, Andrés; García-Falcón, Teresa (Karger, 2012-05)
      [Abstract] Adequate selection of the modality of renal replacement therapy (RRT), ideally based on well-planned predialysis care, informed decision by the patient and timely initiation of dialysis, is essential to optimize ...
    • Ghrelin neutralization during fasting-refeeding cycle impairs the recuperation of body weight and alters hepatic energy metabolism 

      Sangiao-Alvarellos, Susana; Helming, Steffen; Vázquez, María J.; Klussmann, Sven; Cordido, Fernando (Elsevier, 2011)
      [Abstract] Ghrelin, a hormone whose levels increase during food deprivation, plays a pivotal role in the regulation of food intake, energy metabolism and storage, as well as in insulin sensitivity. Here, we investigated ...
    • Giant non-functioning pituitary adenoma: clinical characteristics and therapeutic outcomes 

      Iglesias, Pedro; Arcano, Karina; Triviño, Vanessa; Guerrero-Pérez, Fernando; Rodríguez Berrocal, Víctor; Vior, Carlos; Cordido, Fernando; Villabona, Carles; Díez, Juan J. (Thieme, 2020-01-02)
      [Abstract] Background: Giant pituitary adenoma (≥4 cm) is a rare tumor whose clinical features and prognosis are not well known. Aim: To evaluate the clinical characteristics and therapeutic outcomes of giant non-functioning ...
    • Gonadotrophin-releasing hormone agonist-induced pituitary adenoma apoplexy and casual finding of a parathyroid carcinoma: a case report and review of literature 

      Triviño, Vanessa; Fidalgo, Olga; Juane, Antía; Pombo-Otero, Jorge; Cordido, Fernando (Baishideng Publishing Group, 2019-10-26)
      [Absatract] BACKGROUND Pituitary apoplexy represents one of the most serious, life threatening endocrine emergencies that requires immediate management. Gonadotropin-releasing hormone agonist (GnRHa) can induce pituitary ...
    • Guía clínica de la Sociedad Española de Nefrología para la prevención y tratamiento de la infección peritoneal en diálisis peritoneal 

      Pérez-Fontán, Miguel; Moreiras Plaza, Mercedes; Prieto Velasco, Mario; Quereda Rodriguez-Navarro, Carlos; Bajo Rubio, María Auxiliadora; Borrás Sans, Mercé; Espada Piña, Verónica de la; Pérez Contreras, Javier; Peso Gilsanz, Gloria del; Ponz Clemente, Esther; Quirós Ganga, Pedro; Remón Rodríguez, César; Rodríguez-Carmona, Ana; Sánchez Álvarez, Emilio; Vega Díaz, Nicanor; Vera Rivera, Manuel; Aresté Fosalba, Nuria; Bordes Benítez, Alba; Castro Notario, María José; Fernández Perpén, Antonio; Fernández Reyes, María José; Gasch Blasi, Oriol; Gil Cunquero, José Manuel; Julián Mauro, Juan Carlos; Minguela Pesquera, José Ignacio; Munar Vila, María Antonia; Nú˜nez del Moral, Miguel; Pérez López, Teresa; Portolés Pérez, Jose; Rivera Gorrín, Maite; Rodríguez Suárez, Carmen; Sánchez Camargo, Mario; Soriano Cabrera, María Sagrario (Elsevier, 2022-04)
      [Resumen] Las infecciones peritoneales siguen constituyendo una complicación muy relevante de la diálisis peritoneal, por su incidencia todavía elevada y por sus importantes consecuencias clínicas, en términos de mortalidad, ...
    • High rates of protein intake are associated with an accelerated rate of decline of residual kidney function in incident peritoneal dialysis patients 

      Otero Alonso, Pablo; Pérez-Fontán, Miguel; López Iglesias, Antía; García Falcón, María Teresa; Rodríguez-Carmona, Ana (Oxford Academic, 2019-01-04)
      [Abstract] Background Preservation of residual kidney function (RKF) is a relevant objective in peritoneal dialysis (PD) patients. The influence of dietary protein intake (PI) on this variable has not been adequately ...
    • Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3 

      Heras, Violeta; Sangiao-Alvarellos, Susana; Manfredi-Lozano, María; Sánchez-Tapia, María J.; Ruiz-Pino, Francisco; Roa, Juan; Lara-Chica, Maribel; Morrugares-Carmona, Rosario; Jouy, Nathalie; Abreu, Ana P.; Prevot, Vincent; Belsham, Denise; Vázquez, María J.; Calzado, Marco A.; Pinilla, Leonor; Gaytán, Francisco; Latronico, Ana C.; Kaiser, Ursula B.; Castellano, Juan M.; Tena-Sempere, Manuel (Public Library of Science (PLoS), 2019-11-07)
      [Abstract] Mkrn3, the maternally imprinted gene encoding the makorin RING-finger protein-3, has recently emerged as putative pubertal repressor, as evidenced by central precocity caused by MKRN3 mutations in humans; ...
    • Importance of exercise in the control of metabolic and inflammatory parameters at the moment of onset in type 1 diabetic subjects 

      Martínez-Ramonde, T.; Alonso, N.; Cordido, Fernando; Cervelló, E.; Cañizares, Angelina; Martínez-Peinado, P.; Sempere, J.M.; Roche, E. (Thieme, 2014-05-05)
      [Abstract] The onset of type 1 diabetes coincides with the final phase of β-cell destruction. In some cases, this period is characterized by the presence of a functional reserve of β-cells, favouring an adequate metabolic ...
    • Influence of Age on Rat Bone-Marrow Mesenchymal Stem Cells Potential 

      Fafián Labora, Juan Antonio; Fernández-Pernas, Pablo; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Oreiro, Natividad; Sangiao-Alvarellos, Susana; Mateos, Jesús; Arufe, M.C. (Nature, 2015-11-19)
      [Abstract] Mesenchymal stem cells promising role in cell-based therapies and tissue engineering appears to be limited due to a decline of their regenerative potential with increasing donor age. Six age groups from bone ...
    • Low serum levels of vitamin D are associated with progression of subclinical atherosclerotic vascular disease in peritoneal dialysis patients: a prospective, multicenter study 

      Pérez-Fontán, Miguel; Borrás Sans, Mercé; Bajo Rubio, María Auxiliadora; Rodríguez Carmona, Ana; Betriu, Angels; Valdivielso, José Manuel; Fernández, Elvira (Karger, 2017-02-25)
      [Abstract] Background: The prevalence of subclinical atherosclerosis and the main predictors of progression of this condition in patients undergoing peritoneal dialysis (PD) have been insufficiently investigated. Objectives ...
    • Mitochondrial Dysfunction Plays a Relevant Role in Pathophysiology of Peritoneal Membrane Damage Induced by Peritoneal Dialysis 

      Ramil-Gómez, Olalla; Rodríguez-Carmona, Ana; Fernández-Rodríguez, Jennifer Adriana; Pérez-Fontán, Miguel; Ferreiro-Hermida, Tamara; López Pardo, Mirian; Pérez-López, Teresa; López-Armada, María José (MDPI, 2021-03-13)
      [Abstract] Preservation of the peritoneal membrane is an essential determinant of the long-term outcome of peritoneal dialysis (PD). Epithelial-to-mesenchymal transition (EMT) plays a central role in the pathogenesis of ...
    • Oral glucose-stimulated growth hormone (GH) test in adult GH deficiency patients and controls: potential utility of a novel test 

      Pena-Bello, Lara; Seoane-Pillado, Teresa; Sangiao-Alvarellos, Susana; Outeiriño-Blanco, Elena; Varela-Rodríguez, Bárbara María; Juiz-Valiña, Paula; Cordido, María; Cordido, Fernando (Elsevier para European Federation of Internal Medicine, 2017-06-09)
      [Abstract] Context. The diagnosis of adult GH deficiency requires confirmation with a GH stimulation test. Oral glucose (OG) administration affects GH secretion, initially decreasing and subsequently stimulating GH ...
    • Peritoneal dialysis Is an independent factor associated to lower intima media thickness in dialysis patients free from previous cardiovascular disease 

      Borrás, Mercé; Cambray, Serafí; Crespo-Masip, María; Pérez-Fontán, Miguel; Bozic, Milica; Bermúdez-López, Marcelino; Fernández, Elvira; Betriu, Ángels; Valdivieso, José M. (Frontiers, 2018-12-04)
      [Abstract] Carotid intima media thickness (cIMT) displays prognostic value as a marker of cardiovascular risk in dialysis patients. However, few data are available regarding the impact of dialysis modality on cIMT. The aim ...
    • Peritoneal protein transport during the baseline peritoneal equilibration test is an accurate predictor of the outcome of peritoneal dialysis patients 

      Pérez-Fontán, Miguel; Rodríguez Carmona, Ana; Barreda, D.; López-Muñiz, Andrés; Blanco-Castro, N.; García Falcón, María Teresa (Karger, 2010)
      [Abstract] Background: Peritoneal protein excretion (PPE) is a potential marker of the outcome in peritoneal dialysis (PD) patients. Method: Observational study of a cohort of 269 patients starting PD in a single unit. ...
    • Peritoneal total protein transport assessed from peritoneal equilibration tests using different dialysate glucose concentrations 

      Gomes, Ana Marta; Pérez-Fontán, Miguel; Rodríguez-Carmona, Ana; López-Muñiz, Andrés; Fernández-Villar, Marcos; Peteiro-Cartelle, Javier; García-Falcón, Teresa (SAGE, 2010-09)
      [Abstract] Background: The peritoneal equilibration test (PET) permits assessment of peritoneal protein transport, but this potential marker of outcome in peritoneal dialysis (PD) patients lacks adequate standardization. ...
    • Peritoneal water transport characteristics of diabetic patients undergoing peritoneal dialysis: a longitudinal study 

      Fernandes, Ana; Ribera-Sánchez, Roi; Rodríguez Carmona, Ana; López-Iglesias, Antía; Leite-Costa, Natacha; Pérez-Fontán, Miguel (Karger, 2017-06-21)
      [Abstract] Background: Volume overload is frequent in diabetics undergoing peritoneal dialysis (PD), and may play a significant role in the excess mortality observed in these patients. The characteristics of peritoneal ...
    • Persistent overhydration associates a significant risk of peritoneal infection with enteric germs in patients treated with peritoneal dialysis 

      Fiel, D. Carvalho; Pérez-Fontán, Miguel; López-Iglesias, Antía; Bravo González-Blas, L.; García Gago, L.; García Falcón, María Teresa; Rodríguez-Carmona, Ana (Elsevier, 2019-11)
      [Abstract] Background: Overhydration (OH) complicates frequently the clinical course of Peritoneal Dialysis (PD) patients, and keeps a controversial association with the risk of peritoneal infection. The main objective ...
    • Pituitary MRI features in acromegaly resulting from ectopic GHRH secretion from a neuroendocrine tumor: analysis of 30 cases 

      Potorac, Iulia; Bonneville, Jean-François; Daly, Adrian F.; de Herder, Wouter; Fainstein-Day, Patricia; Chanson, Philippe; Korbonits, Marta; Cordido, Fernando; Lamback, Elisa Baranski; Abid, Mohamed; Raverot, Véronique; Raverot, Gerald; Anda Apiñániz, Emma; Caron, Philippe; Du Boullay, Helene; Bidlingmaier, Martin; Bolanowski, Marek; Laloi-Michelin, Marie; Borson-Chazot, Francoise; Chabre, Olivier; Christin-Maitre, Sophie; Briet, Claire; Díaz-Soto, Gonzalo; Bonneville, Fabrice; Castinetti, Frederic; Gadelha, Mônica R.; Oliveira Santana, Nathalie; Stelmachowska-Banaś, Maria; Gudbjartsson, Tomas; Villar-Taibo, Rocío; Zornitzki, Taiba; Tshibanda, Luaba; Petrossians, Patrick; Beckers, Albert (Oxford University Press on behalf of the Endocrine Society, 2022-05-04)
      [Abstract] Context: Ectopic acromegaly is a consequence of rare neuroendocrine tumors (NETs) that secrete GHRH. This abnormal GHRH secretion drives GH and IGF-1 excess, with a clinical presentation similar to classical ...