• Application of light therapy in older adults with cognitive impairment: A systematic review 

      Cibeira, Nuria; Maseda, Ana; Lorenzo-López, Laura; Rodríguez-Villamil, José Luis; López-López, Rocío; Millán-Calenti, José Carlos (Elsevier, 2020-08-02)
      [Abstract] This systematic review aims to assess the efficacy of light therapy on behavioural and psychological symptoms of dementia (BPSD), cognition, functional status, and quality of life in older adults with cognitive ...
    • Association of torquetenovirus viremia with physical frailty and cognitive impairment in three independent european cohorts 

      Giacconi, Robertina; Laffon, Blanca; Costa, Solange; Teixeira-Gomes, Armanda; Maggi, Fabrizio; Macera, Lisa; Spezia, Pietro Giogio; Piacenza, Francesco; Bürkle, Alexander; Moreno-Villanueva, María; Bonassi, Stefano; Valdiglesias, Vanessa; Teixeira, Joao Paulo; Dollé, Martijn E.T.; Rietman, M. Liset; Jansen, Eugène; Grune, Tilman; Gonos, Efstathios S.; Franchesci, Claudio; Capri, Miriam; Weinberger, Birgit; Sikora, Ewa; Stuetz, Wolfgang; Toussaint, Olivier; Debacq-Chainiaux, Florence; Hervonen, Antti; Hurme, Mikko; Slagboom, P. Eline; Schön, Christiane; Bernhardt, Jürgen; Breusing, Nicolle; Pásaro, Eduardo; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Provinciali, Mauro; Malavolta, Marco (Karger, 2023-01-10)
      [Abstract] Introduction: Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, the major component of the human blood virome, ...
    • Bright Light Therapy in Older Adults with Moderate to Very Severe Dementia: Immediate Effects on Behavior, Mood, and Physiological Parameters 

      Cibeira, Nuria; Maseda, Ana; Lorenzo-López, Laura; González-Abraldes, Isabel; López-López, Rocío; Rodríguez-Villamil, José Luis; Millán-Calenti, José Carlos (MDPI, 2021-08-19)
      [Abstract] Bright light therapy (BLT) has demonstrated positive short- and long-term effects in people with cognitive impairment or dementia; however, the immediate impact of BLT sessions has been scarcely investigated. ...
    • Caregiver's distress related to the patient's neuropsychiatric symptoms as a function of the care-setting 

      Lorenzo-López, Laura; Labra, Carmen de; Maseda, Ana; Lorenzo, Trinidad; Agrafojo Nieto, María Helena; Rodríguez-Villamil, José Luis; González-Abraldes, Isabel; Millán-Calenti, José Carlos (Elsevier, 2016-09-09)
      [Abstract] Prevalence of neuropsychiatric symptoms (NPS) and correlation between its intensity and caregiver distress were evaluated as a function of the care-setting in a cross-sectional study including 72 patient-caregiver ...
    • Changes in frailty status in a community-dwelling cohort of older adults: the VERISAÚDE study 

      Lorenzo-López, Laura; López-López, Rocío; Maseda, Ana; Buján, Ana; Rodríguez-Villamil, José Luis; Millán-Calenti, José Carlos (Elsevier, 2018-11-15)
      [Abstract] Objectives: Greater understanding of changes in the degree of frailty is important for clarifying the natural history of frailty and may help clinical decision-making regarding preventive interventions. The ...
    • Clinical and Neuropsychological Correlates of Prefrailty Syndrome 

      Lorenzo-López, Laura; Blanco-Fandiño, J.; Cibeira, Nuria; Buján, Ana; López-López, Rocío; Maseda, Ana; Millán-Calenti, José Carlos (Frontiers Media S.A., 2020-11-09)
      [Abstract] Physical frailty is closely associated with cognitive impairment. We aim to investigate the neuropsychological profiles of prefrail and non-frail dementia-free community-dwelling older adults using a comprehensive ...
    • Cognitive frailty: a conceptual systematic review and an operational proposal for future research 

      Facal, David; Maseda, Ana; Pereiro Rozas, Arturo; Gandoy-Crego, Manuel; Lorenzo-López, Laura; Yanguas, Javier; Millán-Calenti, José Carlos (Elsevier, 2018-12-07)
      [Abstract] Objective. To analyze the definition of “cognitive frailty” and to study the conceptual and operational definitions used and their implications for empirical research. The relationships between this concept and ...
    • Determinants of Quality of Life in Pre-Frail Older Adults According to Phenotypic Criteria: the VERISAUDE Study 

      Maseda, Ana; Lorenzo-López, Laura; Lorenzo, Trinidad; Diego-Díez, Clara; Alonso-Búa, Begoña; López-López, Rocío; Millán-Calenti, José Carlos (Springer para The International Society for Quality-of-Life Studies (ISQOLS), 2017-02-04)
      [Abstract] Frailty is a dynamic clinical syndrome considered as part of an age-associated continuum of severity, including pre-frailty as an intermediate frailty status with potential reversibility to robustness. The main ...
    • Dual and triple tasks performance in institutionalized prefrail and frail older adults 

      Lorenzo-López, Laura; Campos-Magdaleno, María; López-López, Rocío; Facal, David; Pereiro, A.X.; Maseda, Ana; Blanco-Fandiño, J.; Millán-Calenti, José Carlos (Willey, 2020-07-13)
      [Abstract] Objective: The aim of this pilot study was to investigate differences on dual- and triple-task performance in institutionalized prefrail and frail older adults. Performance on these tasks is relevant since ...
    • Dysphagia and its association with other health-related risk factors in institutionalized older people: a systematic review 

      Leira, Julia; Maseda, Ana; Lorenzo-López, Laura; Cibeira, Nuria; López-López, Rocío; Lodeiro-Fernández, Leire; Millán-Calenti, José Carlos (Elsevier, 2023-03-07)
      [Abstract] Background: Dysphagia is considered a geriatric syndrome that is characterized by inability to or difficulty in safely and effectively forming or moving the food bolus toward the esophagus. This pathology is ...
    • Effectiveness of a Chess-Training Program for Improving Cognition, Mood, and Quality of Life in Older Adults: A Pilot Study 

      Cibeira, Nuria; Lorenzo-López, Laura; Maseda, Ana; Blanco-Fandiño, J.; López-López, Rocío; Millán-Calenti, José Carlos (Elsevier, 2021-06-04)
      [Abstract] Background. Regular practice of a cognitively stimulating activity, such as chess, can help maintain a healthy cognitive, social, and psychological state during the aging process. Objective. To evaluate ...
    • Effects of degree of urbanization and lifetime longest-held occupation on cognitive impairment prevalence in an older spanish population 

      Lorenzo-López, Laura; Millán-Calenti, José Carlos; López-López, Rocío; Diego-Díez, Clara; Laffon, Blanca; Pásaro, Eduardo; Valdiglesias, Vanessa; Maseda, Ana (Frontiers, 2017-02-13)
      [Abstract] Our aim was to estimate the prevalence of cognitive impairment in rural and urban elderly populations and to examine the relationship between lifetime occupation and general cognitive performance. A cross-sectional ...
    • Exploring genetic outcomes as frailty biomakers 

      Valdiglesias, Vanessa; Sánchez-Flores, María; Marcos-Pérez, Diego; Lorenzo-López, Laura; Maseda, Ana; Millán-Calenti, José Carlos; Pásaro, Eduardo; Laffon, Blanca (Oxford, 2018-04-19)
      [Abstract] Frailty has emerged as a reliable measure of the aging process. Because the early detection of frailty is crucial to prevent or even revert it, the use of biomarkers would allow an earlier and more objective ...
    • Frailty in older adults Is associated with plasma concentrations of inflammatory mediators but not with lymphocyte subpopulations 

      Marcos-Pérez, Diego; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Gostner, Johanna; Fuchs, Dietmar; Pásaro, Eduardo; Laffon, Blanca; Valdiglesias, Vanessa (Frontiers, 2018-05-16)
      [Abstract] Frailty denotes a multidimensional syndrome that gives rise to vulnerability to stressors and leads to an increase of the age-related decline of different physiological systems and cognitive abilities. Aging-related ...
    • Frailty status in older adults is related to alterations in indoleamine 2,3-dioxygenase 1 and guanosine triphosphate cyclohydrolase I enzymatic pathways 

      Marcos Pérez, Diego; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Strasser, Barbara; Gostner, Johanna; Fuchs, Dietmar; Pásaro, Eduardo; Valdiglesias, Vanessa; Laffon, Blanca (Elsevier para AMDA (The Society for Post-Acute and Long-Term Cara Medicine), 2017-08-08)
    • Frailty syndrome and genomic instability in older adults: suitability of the cytome micronucleus assay as a diagnostic tool 

      Sánchez-Flores, María; Marcos-Pérez, Diego; Lorenzo-López, Laura; Maseda, Ana; Millán-Calenti, José Carlos; Bonassi, Stefano; Pásaro, Eduardo; Laffon, Blanca; Valdiglesias, Vanessa (Oxford, 2018-01-13)
      [Abstract] Frailty, a condition involving increased risk of disability and mortality in older adults, has emerged as a reliable way to predict the effect of aging. Genomic instability may help to anticipate recognition of ...
    • Immune activation in older-aged individuals is associated with genetic instability (or vice versa) 

      Gostner, Johanna; Sánchez-Flores, María; Marcos-Pérez, Diego; Lorenzo-López, Laura; Maseda, Ana; Millán-Calenti, José Carlos; Fuchs, Dietmar; Bonassi, Stefano; Pásaro, Eduardo; Laffon, Blanca; Valdiglesias, Vanessa (De Gruyter, 2019-06-15)
    • Immune biomarkers in older adults: role of physical activity 

      Valdiglesias, Vanessa; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Marcos Pérez, Diego; López-Cortón-Facal, Ana; Strasser, Barbara; Fuchs, Dietmar; Laffon, Blanca; Millán-Calenti, José Carlos; Pásaro, Eduardo (Taylor & Francis, 2017-05-19)
      [Abstract] Aging is associated with a decline in the normal functioning of the immune system. Several studies described the relationship between immunological alterations, including immunosenescence and inflammation, and ...
    • Is salivary chromogranin A a valid psychological stress biomarker during sensory stimulation in people with advanced dementia? 

      Valdiglesias, Vanessa; Maseda, Ana; Lorenzo-López, Laura; Pásaro, Eduardo; Millán-Calenti, José Carlos; Laffon, Blanca (IOS Press, 2016-12-20)
      [Abstract] Salivary chromogranin A (sCgA) is gaining attention as a biomarker of psychological stress. The objective of this work was to determine whether individualized music intervention and multisensory stimulation ...
    • Is Sensory Loss an Understudied Risk Factor for Frailty? A Systematic Review and Meta-analysis 

      Tan, Benjamin Kye Jyn; Man, Ryan Eyn Kidd; Gan, Alfred Tau Liang; Fenwick, Eva K; Varadaraj, Varshini; Swenor, Bonnielin K.; Gupta, Preeti; Wong, Tien Yin; Trevisan, Caterina; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Schwanke, Carla Helena Augustin; Liljas, Ann; Al Snih, Soham; Tokuda, Yasuharu; Lamoureux, Ecosse Luc (Oxford Academic, 2020-07-06)
      [Abstract] Background. Age-related sensory loss and frailty are common conditions among older adults, but epidemiologic research on their possible links has been inconclusive. Clarifying this relationship is important ...