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Modulatory effects mediated by metabotropic glutamate receptor 5 on lateral geniculate nucleus relay cells
dc.contributor.author | Labra, Carmen de | |
dc.contributor.author | Rivadulla, Casto | |
dc.contributor.author | Cudeiro, Javier | |
dc.date.accessioned | 2015-05-22T09:19:32Z | |
dc.date.available | 2015-05-22T09:19:32Z | |
dc.date.issued | 2005-01-18 | |
dc.identifier.citation | Labra C, Rivadulla C, Cudeiro J. Modulatory effects mediated by metabotropic glutamate receptor 5 on lateral geniculate nucleus relay cells. Eur J Neurosci. 2005;21:403-10. | es_ES |
dc.identifier.uri | http://hdl.handle.net/2183/14542 | |
dc.description.abstract | [Abstract] Glutamate is thought to be the excitatory neurotransmitter in the lateral geniculate nucleus (LGN) of the cat, mediating visual transmission from the retina via ionotropic receptors of both d,l-α-amino-3-hydroxy-5-α-methyl-4-isoxazolepropionate and N-methyl-d-aspartate subtypes. Moreover, glutamate also exerts an important modulatory influence on LGN cells, where metabotropic glutamate receptors (mGluRs) seem to play a crucial role. Here we show in anesthetized adult cats that iontophoretic application of the specific mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) produced two, distinctly different, effects on LGN neurons. Visual responses to flashing spots and drifting gratings were attenuated (decreased by an average of 59%) in 13 of 23 of the cells but augmented (increased by an average of 60%) in 10 of 23 of the cells. Further, in each case when the specific mGluR5 agonist (R,S)-2-chloro-5-hydroxyphenylglycine was applied, the effects obtained were the opposite to those of MPEP. Data obtained in a second group of experiments to determine a possible interaction between mGluR5 blockade by MPEP and glutamate ionotropic receptors show that, in the majority of neurons (11 of 15, 73%), the MPEP-mediated effects seem to be independent of N-methyl-d-aspartate and d,l-α-amino-3-hydroxy-5-α-methyl-4-isoxazolepropionate receptor activity. Our results demonstrate a physiological role for mGluR5 in controlling retinal input and show, in vivo, a more intricate scenario than previously suggested, highlighting the complexity of metabotropic receptor interactions with excitatory and inhibitory elements in the thalamus. | es_ES |
dc.description.sponsorship | Ministerio de Ciencia y Tecnología; BFI2002-3200 | |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation.uri | http://dx.doi.org/10.1111/j.1460-9568.2005.03847.x | es_ES |
dc.rights | This is a peer reviewed version of the article which has been published in the final form at Wiley Online Library. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving. | es_ES |
dc.subject | Cat | es_ES |
dc.subject | Glutamate | es_ES |
dc.subject | Metabotropic receptors | es_ES |
dc.subject | 2-methyl-6-(phenylethynyl)-pyridine | es_ES |
dc.subject | Retinal input | es_ES |
dc.subject | Vision | es_ES |
dc.title | Modulatory effects mediated by metabotropic glutamate receptor 5 on lateral geniculate nucleus relay cells | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
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