Endocannabinoid CB1 receptors modulate visual output from the thalamus
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Endocannabinoid CB1 receptors modulate visual output from the thalamusFecha
2011-07-20Cita bibliográfica
Dasilva MA, Grieve KL, Cudeiro J, Rivadulla C. Endocannabinoid CB1 receptors modulate visual output from the thalamus. Psychopharmacol. 2012;219:835-45.
Resumen
[Abstract] Rationale Endocannabinoids have emerged as a modulatory
brain system affecting different types of synapses,
broadly distributed throughout the CNS, which explain
the diverse psychophysical effects observed following
activation of the endocannabinoid system.
Objectives and methods The present study aimed to
characterize the effect of CB1-mediated activity in the
visual thalamus. In vivo single-unit extracellular recordings
were performed in anaesthetized adult pigmented rats,
measuring visual and spontaneous activity, combined with
application of CB1 receptor agonists (anandamide, 2-AG,
and O2545) and one antagonist, AM251.
Results CB1 receptors activation revealed two cellular populations,
with excitatory effects on ∼28% of cells and
inhibitory in ∼72%, actions which were blocked by the
antagonist AM251. The agonist action significantly altered
both spontaneous and visual activity, shifting the signal-tonoise
ratio (S/N), with accompanying changes in the variability
within the visual response. Increased responses by agonist
application were accompanied by a decrease in S/N and an
increase in variability, while those cells inhibited by the
agonist showed an increase in S/N and a decrease in variability.
There was no obvious correlation between the two effects and
any other response property suggesting a more general role in
modulating all information passing from LGN to cortex.
Conclusions Our data support a role for CB1 at the level of the
thalamus acting as a dynamic modulator of visual information
being sent to the cortex, apparently maintaining the salience of
the signal within upper and lower boundaries. This may
account for some of the behavioral effects of cannabis.
Palabras clave
Endocannabinoids
dLGN
Thalamus
Vision
Cannabinoids
CB1
dLGN
Thalamus
Vision
Cannabinoids
CB1
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