Fluorescence study of tetracaine–cyclodextrin inclusion complexes

Abstract

The steady-state fluorescence emission from the local anaesthetic tetracaine (TCA) in water-solvent mixtures and in the presence of α-, β- and γ-cyclodextrin (CD) was investigated at various pH values. Emission was observed from the locally and the intramolecular charge transfer excited states. The TCA-CD system was found to be characterised by 1:1 associate in every case. The association constants of each complex were determined.