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Longitudinal stability of molecular endotypes of knee osteoarthritis patients
(Elsevier, 2024-11-08)
[Abstract]
Objective: To assess the longitudinal stability of biomarker-based molecular endotypes of knee osteoarthritis (KOA) participants from APPROACH and to evaluate the consistency of findings in an independent ...
Fluctuation of bone marrow lesions and inflammatory MRI markers over 2 years and concurrent associations with quantitative cartilage loss
(Sage, 2024-10-26)
[Abstract] Objective: To assess whether change of semiquantitatively magnetic resonance imaging (MRI)-defined bone marrow lesions (BMLs) and inflammatory markers is associated with change in quantitatively-assessed cartilage ...
Mitochondrial role on cellular apoptosis, autophagy, and senescence during osteoarthritis pathogenesis
(MDPI, 2024-06-04)
Pathogenesis
Andrea Dalmao-Fernández 1,2 , Tamara Hermida-Gómez 1,3,4, Uxia Nogueira-Recalde 1, Ignacio Rego-Pérez 1 ,
Francisco J. Blanco-Garcia 1,5,* and Mercedes Fernández-Moreno 1,3,*
1 Grupo de Investigación en Reumatología (GIR), Instituto de...
Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade de A Coruña (UDC), 15071 A Coruña, Spain; a.d.fernandez@farmasi.uio.no (A.D.-F.); tamara.hermida.gomez@sergas.es (T.H.-G.); uxia...
Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade de A Coruña (UDC), 15071 A Coruña, Spain; a.d.fernandez@farmasi.uio.no (A.D.-F.); tamara.hermida.gomez@sergas.es (T.H.-G.); uxia...
Severity and progression of structural hand OA is not associated with progression of structural knee OA: the IMI-APPROACH cohort
(Elsevier, 2024-05)
[Abstract]. Objective. To investigate whether structural hand OA or its progression is associated with structural knee OA progression after two years in a population with symptomatic knee OA.
Methods. We used baseline and ...
Higher synovial immunohistochemistry reactivity of IL-17A, Dkk1, and TGF-β1 in patients with early psoriatic arthritis and rheumatoid arthritis could predict the use of biologics
(MDPI, 2024-04-08)
[Abstract] Background: Delay in diagnosis and therapy in patients with arthritis commonly leads to progressive articular damage. The study aimed to investigate the immunohistochemical reactivity of synovial cytokines ...
Can gait patterns be explained by joint structure in people with and without radiographic knee osteoarthritis?: data from the IMI-APPROACH cohort
(Springer Nature, 2024-03-27)
[Abstract]
Objective: To determine the association between joint structure and gait in patients with knee osteoarthritis (OA).
Methods: IMI-APPROACH recruited 297 clinical knee OA patients. Gait data was collected ...
Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort
(Springer Nature, 2024-03-12)
[Abstract] To delineate the phenotype of erosive hand osteoarthritis (EHOA) in a Spanish population and assess its correlation with metabolic syndrome. We conducted a cross-sectional study using baseline data from the ...
Mitonuclear epistasis involving TP63 and haplogroup Uk: risk of rapid progression of knee OA in patients from the OAI
(Elsevier, 2024-01-06)
Balboa-Barreiro ‡, Francisco J.
Blanco # § 1, Ignacio Rego-Pérez # 1 2
# Grupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A
Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas...
, Universidade da Coruña (UDC), C/ As Xubias de Arriba 84, 15006 A Coruña, Spain † Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain ‡ Unidad de Apoyo a la Investigación, Grupo de Investigación...
, Universidade da Coruña (UDC), C/ As Xubias de Arriba 84, 15006 A Coruña, Spain † Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain ‡ Unidad de Apoyo a la Investigación, Grupo de Investigación...
Proteomic profiling of human menisci from mild joint degeneration and end-stage osteoarthritis versus healthy controls
(Elsevier, 2023-12)
O A B S T R A C TProteomic profiling of human menisci from
end-stage osteoarthritis versus healthy cont
Rocío Paz-Gonz�alez a, Aleksandra Turkiewicz d, Neserin
Francisco J. Blanco a,b, Martin Englund d,f, Patrik €Onne
a Grupo de Investigaci�on de...
Reumatología (GIR), Unidad de Prote�omica. INIBIC-Hospital Unive b Grupo de Reumatología y Salud, Departamento de Fisioterapia y Medicina. Centro de investiga c Centro de Investigaci�on Biom�edica en Red de Bioingeniería, Biomateriales y Nanomedicina (CI d...
Reumatología (GIR), Unidad de Prote�omica. INIBIC-Hospital Unive b Grupo de Reumatología y Salud, Departamento de Fisioterapia y Medicina. Centro de investiga c Centro de Investigaci�on Biom�edica en Red de Bioingeniería, Biomateriales y Nanomedicina (CI d...
Study of hydrogen sulfide biosynthesis in synovial tissue from diabetes-associated osteoarthritis and its influence on macrophage phenotype and abundance
(Springer, 2023-06-19)
[Abstract] Type 2 diabetes (DB) is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Synovial macrophages from OA patients with DB ...
