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Circulating miR-200c as a diagnostic and prognostic biomarker for gastric cancer
(BioMed Central, 2012-09-06)
[Abstract]
Background. MicroRNAs are aberrantly expressed and correlate with tumourigenesis and the progression of solid tumours. The miR-200 family determines the epithelial phenotype of cancer cells and regulates ...
Circulating miR-200c and miR-141 and outcomes in patients with breast cancer
(BioMed Central, 2015)
[Abstract]
Background. The deregulation of microRNAs in both tumours and blood has led to the search for microRNAs to indicate the presence of cancer and predict prognosis. We hypothesize the deregulation of miR-200c/miR-141 ...
Characterization of HMGB1/2 Interactome in Prostate Cancer by Yeast Two Hybrid Approach: Potential Pathobiological Implications
(MDPI, 2019-11-05)
[Abstract] High mobility group box B (HMGB) proteins are pivotal in the development of cancer. Although the proteomics of prostate cancer (PCa) cells has been reported, the involvement of HMGB proteins and their interactome ...
Hakai reduces cell-substratum adhesion and increases epithelial cell invasion
(BioMed Central, 2011-11-03)
[Abstract]
Background. The dynamic regulation of cell-cell adhesions is crucial for developmental processes, including tissue formation, differentiation and motility. Adherens junctions are important components of the ...
Clinical implications of epithelial cell plasticity in cancer progression
(Elsevier, 2015)
[Abstract] In the last few years, the role of epithelial cell plasticity in cancer biology research has gained increasing attention. This concept refers to the ability of the epithelial cells to dynamically switch between ...
Potential role of sugar transporters in cancer and their relationship with anticancer therapy
(Hindawi, 2010-06-20)
[Abstract] Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. ...
A novel procedure for protein extraction from formalin-fixed paraffin-embedded tissues
(Wiley, 2011-05-18)
[Abstract] Most of the archived pathological specimens in hospitals are kept as formalin-fixed paraffin-embedded tissues (FFPE) for long-term preservation. Up to now, these samples are only used for immunohistochemistry ...
Role of the microtubule-targeting drug vinflunine on cell-cell adhesions in bladder epithelial tumour cells
(BioMed Central, 2014-07-10)
[Abstract]
Background. Vinflunine (VFL) is a microtubule-targeting drug that suppresses microtubule dynamics, showing anti-metastatic properties both in vitro and in living cancer cells. An increasing body of evidence ...
Biological influence of Hakai in cancer: a 10-year review
(Springer, 2012-02-19)
[Abstract] In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues, and attach to a second site. Hakai was discovered as an E3 ubiquitin-ligase that mediates the ...
miR-203 regulates cell proliferation through Its influence on Hakai expression
(PLoS, 2012-12-20)
Gene expression is potently regulated through the action of microRNAs (miRNAs). Here, we present evidence of a miRNA regulating Hakai protein. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational ...
