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Inflammation-mediated damage in progressing lacunar infarctions: a potential therapeutic target
(American Heart Association, 2002-04-01)
[Abstract] Background and purpose: The mechanisms underlying neurological deterioration in patients with lacunar infarction are not completely understood. In this study, we sought to investigate the role of proinflammatory ...
Time trends in intracerebral hemorrhage associated with oral anticoagulation and its risks factors in Spain from 2008 to 2015
(Karger, 2020-12-15)
[Abstract] Background: Intracerebral hemorrhage (ICH) is 7- to 10-fold higher in anticoagulated patients. Given the more extended use of oral anticoagulants, an increase in the prevalence of ICH associated with oral ...
RP11-362K2.2:RP11-767I20.1 genetic variation is associated with post-reperfusion therapy parenchymal hematoma: a GWAS meta-analysis
(MDPI, 2021-07-16)
[Abstract] Stroke is one of the most common causes of death and disability. Reperfusion therapies are the only treatment available during the acute phase of stroke. Due to recent clinical trials, these therapies may increase ...
Association of high serum levels of growth factors with good outcome in ischemic stroke: a multicenter study
(Springer Nature, 2019-11-25)
[Abstract] The main objective of this research work was to study the association of serum levels of growth factors (GF) and SDF-1α with the functional outcome and reduction of lesion volume in ischemic stroke patients. In ...
Worse outcome in stroke patients treated with rt-PA without early reperfusion: associated factors
(Springer Nature, 2017-11-07)
[Abstract] Based on preclinical studies suggesting that recombinant tissue plasminogen activator (rt-PA) may promote ischemic brain injuries, we investigated in patients the possible risk of worse clinical outcome after ...
Preclinical validation of human recombinant glutamate-oxaloacetate transaminase for the treatment of acute ischemic stroke
(Cell Press, 2024-11-15)
[Summary] The blood enzyme glutamate-oxaloacetate transaminase (GOT) has been postulated as an effective therapeutic to protect the brain during stroke. To demonstrate its potential clinical utility, a new human recombinant ...
A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment
(Elsevier, 2023-12-15)
[Abstract]
Background: Thrombolytic recombinant tissue plasminogen activator (r-tPA) treatment is the only pharmacologic intervention available in the ischemic stroke acute phase. This treatment is associated with an ...
Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma
(Oxford University Press, 2021-03-16)
[Abstract] Haemorrhagic transformation is a complication of recombinant tissue-plasminogen activator treatment. The most severe form, parenchymal haematoma, can result in neurological deterioration, disability, and death. ...
The clinical-DWI mismatch: a new diagnostic approach to the brain tissue at risk of infarction
(American Academy of Neurology, 2004-06-21)
[Abstract]
Objective: To evaluate the usefulness of a mismatch between the severity of acute clinical manifestations and the diffusion-weighted imaging (DWI) lesion in predicting early stroke outcome and infarct ...
Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke
(American Heart Association, 2002-12-05)
[Abstract] Background and purpose: Matrix metalloproteinase-9 (MMP-9) activity has been associated with hemorrhagic transformation (HT) in experimental models of cerebral ischemia. Our aim was to investigate the relationship ...
