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Indoleamine, 2-3 dioxygenase activity could be an early marker of graft rejection in heart transplantation

Suárez-Fuentetaja, Natalia; Doménech, Nieves; Paniagua-Martín, María J.; Marzoa Rivas, Raquel; Barge-Caballero, Eduardo; Grille Cancela, Zulaika; Pombo-Otero, Jorge; Muñiz, Javier; Castro-Beiras, Alfonso; Crespo-Leiro, María Generosa (Elsevier, 2012-11-10)

[Abstract] Background. The indoleamine, 2-3 dioxygenase (IDO) is an inducible intracellular enzyme with immunosuppressive effects mainly on lymphocyte populations. It has been postulated that indirect determination of IDO ...

Mitochondrial haplogroups H and J: risk and protective factors for ischemic cardiomyopathy

Fernández Caggiano, Mariana; Barallobre-Barreiro, Javier; Rego-Pérez, Ignacio; Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Grille Cancela, Zulaika; Blanco García, Francisco J; Doménech, Nieves (PLoS, 2012-08-28)

[Abstract] Background. Since mitochondria are the principal source of reactive oxygen species (ROS), these organelles may play an important role in ischemic cardiomyopathy (IC) development. The mitochondrial genome may ...

In-hospital postoperative infection after heart transplantation: risk factors and development of a novel predictive score

Fernández-Ugidos, Paula; Barge-Caballero, Eduardo; Gómez-López, Rocío; Paniagua-Martín, María J.; Barge-Caballero, Gonzalo; Couto-Mallón, David; Solla-Buceta, Miguel; Iglesias-Gil, Carmen; Aller-Fernández, Vanesa; González-Barbeito, Miguel; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Wiley, 2019-05-11)

[Abstract] Introduction: Infection is one of the most significant complications following heart transplantation (HT). The aim of this study was to identify specific risk factors for early postoperative infections in HT ...

Incidence, Risk Factors and Prognostic Impact of Cytomegalovirus Infection After Heart Transplantation

Méndez-Eirín, Elizabet; Barge-Caballero, Eduardo; Paniagua-Martín, María J.; Barge-Caballero, Gonzalo; Couto-Mallón, David; Grille Cancela, Zulaika; Blanco-Canosa, Paula; Cañizares-Castellanos, Angelina; González Barbeito, Miguel; Aller Fernández, Ana Vanesa; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Elsevier, 2020-03-20)

[Abstract] Introduction and objectives. To assess the risk factors of CMV infection after heart transplant (HT) and its influence on long-term prognosis. Methods. We conducted a retrospective single-centre study of ...

Determinants of maximal oxygen uptake in patients with heart failure

Roibal-Pravio, J.; Barge-Caballero, Eduardo; Barbeito Caamaño, Cayetana; Paniagua-Martín, María J.; Barge-Caballero, Gonzalo; Couto-Mallón, David; Pardo-Martínez, Patricia; Grille Cancela, Zulaika; Blanco-Canosa, Paula; García-Pinilla, José Manuel; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Wiley Online Library, 2021-03-27)

[Abstract] Aims Maximum oxygen uptake (VO₂max) is an essential parameter to assess functional capacity of patients with heart failure (HF). We aimed to identify clinical factors that determine its value, as they have not ...

Prognostic significance of heart rate and its long-term trend in cardiac transplant patients

Barge-Caballero, Eduardo; Jiménez-López, Jesús; Chávez-Leal, Sergio; Barge-Caballero, Gonzalo; Paniagua-Martín, María J.; Marzoa Rivas, Raquel; Grille Cancela, Zulaika; Cuenca-Castillo, José J.; Castro-Beiras, Alfonso; Crespo-Leiro, María Generosa (Elsevier para Sociedad Española de Cardiología, 2015-04-11)

[Abstract] Introduction and objectives. The aim of the present study was to examine the prognostic significance of heart rate and its trend in heart transplantation. Methods. This observational study enrolled 170 patients ...

Body surface area as a prognostic marker in chronic heart failure patients: results from the Heart Failure Registry of the Heart Failure Association of the European Society of Cardiology

Zafrir, Barak; Salman, Nabeeh; Crespo-Leiro, María Generosa; Anker, Stefan; Coats, Andrew J.; Ferrari, Roberto; Filippatos, Gerasimos; Maggioni, Aldo P.; Mebazaa, Alexandre; Piepoli, Massimo Francesco; Ruschitzka, Frank; Paniagua-Martín, María J.; Segovia-Cubero, Javier; Laroche, Cecile; Amir, Offer (Wiley, 2016-07-18)

[Abstract] AIMS: The 'obesity paradox' is consistently observed in patients with heart failure (HF). We investigated the relationship of body surface area (BSA) to mortality and hospitalizations in patients with chronic ...

Circulating miR-181a-5p as a New Biomarker for Acute Cellular Rejection in Heart Transplantation

Constanso-Conde, Ignacio; Hermida-Prieto, Manuel; Barge-Caballero, Eduardo; Núñez, Lucía; Pombo-Otero, Jorge; Suárez-Fuentetaja, Natalia; Paniagua-Martín, María J.; Barge-Caballero, Gonzalo; Couto-Mallón, David; Pan Lizcano, Ricardo Francisco; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Elsevier, 2020-06-07)

[Abstract] Background: Acute cellular rejection (ACR) is a major complication in heart transplantation (HTx). Endomyocardial biopsy is the reference method for early detection of ACR, but a new non-invasive approach is ...

Is Becker dystrophinopathy a contraindication to heart transplant?: experience in a single institution

Ascencio-Lemus, Marisol Guadalupe; Barge-Caballero, Eduardo; Paniagua-Martín, María J.; Barge-Caballero, Gonzalo; Couto-Mallón, David; Crespo-Leiro, María Generosa (Elsevier, 2018-07-17)

AGT haplotype in ITGA4 gene is related to antibody-mediated rejection in heart transplant patients

Núñez, Lucía; Marrón Liñares, Grecia Manuela; Crespo-Leiro, María Generosa; Barge-Caballero, Eduardo; Álvarez López, Eloy; Suárez-Fuentetaja, Natalia; Paniagua-Martín, María J.; Pombo-Otero, Jorge; Muñiz, Javier; Tan, Carmela D.; Rene Rodríguez, E.; Vázquez Rodríguez, José Manuel (Stanislaw Stepkowski,, 2019-07-23)

[Abstract] Introduction. One of the main problems involved in heart transplantation (HT) is antibody-mediated rejection (AMR). Many aspects of AMR are still unresolved, including its etiology, diagnosis and treatment. ...

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