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Imipenem-relebactam susceptibility in enterobacterales isolates recovered from ICU patients from Spain and Portugal (SUPERIOR and STEP studies)
(American Society of Microbiology, 2022-08-31)
[Abstract] Imipenem-relebactam is a novel β-lactam-β-lactamase inhibitor combination. We evaluated the in vitro activity of imipenem-relebactam and comparators against Enterobacterales clinical isolates recovered in 8 ...
Current positioning against severe infections due to klebsiella pneumoniae in hospitalized adults
(MDPI, 2022-08-27)
[Abstract] Infections due to Klebsiella pneumoniae have been increasing in intensive care units (ICUs) in the last decade. Such infections pose a serious problem, especially when antimicrobial resistance is present. We ...
A new live auxotrophic vaccine induces cross-protection against klebsiella pneumoniae infections in mice
(MDPI, 2022-06-16)
[Abstract] The development of a whole-cell vaccine from bacteria auxotrophic for D-amino acids present in the bacterial cell wall is considered a promising strategy for providing protection against bacterial infections. ...
Unravelling the mechanisms causing murepavadin resistance in Pseudomonas aeruginosa: lipopolysaccharide alterations and its consequences
(Frontiers Media, 2024-12-06)
[Abstract] Introduction: Murepavadin is an antimicrobial peptide (AMP) in clinical development that selectively targets Pseudomonas aeruginosa LptD and whose resistance profile remains unknown. We aimed to explore genomic ...
Mutant prevention concentrations, in vitro resistance evolution dynamics, and mechanisms of resistance to imipenem and imipenem/relebactam in carbapenem-susceptible Klebsiella pneumoniae isolates showing ceftazidime/avibactam resistance
(American Society of Microbiology, 2024-11-15)
[Abstract] Klebsiella pneumoniae carbapenemase (KPC) variants selected during ceftazidime/avibactam treatment usually develop susceptibility to carbapenems and carbapenem/β-lactamase inhibitors, such as imipenem and ...
Dispersal history of SARS-CoV-2 in Galicia, Spain
(John Wiley & Sons, 2024-06-28)
[Abstract] The dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission are influenced by a variety of factors, including social restrictions and the emergence of distinct variants. In this ...
Rapid and simple morphological assay for determination of susceptibility/resistance to combined ciprofloxacin and ampicillin, independently, in Escherichia coli
(MDPI, 2024-07-20)
[Abstract] Current antibiograms cannot discern the particular effect of a specific antibiotic when the bacteria are incubated with a mixture of antibiotics. To prove that this task is achievable, Escherichia coli strains ...
Emergence of carbapenemase genes in gram-negative bacteria isolated from the wastewater treatment plant in A Coruña, Spain
(MDPI, 2024-02-17)
[Abstract] Wastewater treatment plants (WWTPs) are recognized as important niches of antibiotic-resistant bacteria that can be easily spread to the environment. In this study, we collected wastewater samples from the WWTP ...
Epidemiology, resistance genomics and susceptibility of acinetobacter species: results from the 2020 spanish nationwide surveillance study
(European Centre for Disease Prevention and Control (ECDC), 2024-04)
[Abstract] BackgroundAs increasing antibiotic resistance in Acinetobacter baumannii poses a global healthcare challenge, understanding its evolution is crucial for effective control strategies.AimWe aimed to evaluate the ...
CARB-ES-19 multicenter study of carbapenemase-producing klebsiella pneumonia e and escherichia coli from all spanish provinces reveals interregional spread of high-risk clones such as ST307/OXA-48 and ST512/KPC-3
(Frontiers Media, 2022-06-30)
[Abstract]
Objectives: CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) ...
