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Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

Varela-Eirín, Marta; Varela Vázquez, Adrián; Guitián-Caamaño, Amanda; Luis Paíno, Carlos; Mato-Abad, Virginia; Largo, Raquel; Aasen, Trond; Tabernero, Arantxa; Fonseca, Eduardo; Kandouz, Mustapha; Caeiro, José Ramón; Blanco, Alfonso; Mayan, Maria D. (Nature Publishing Group, 2018-12-05)

[Abstract] Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and ...