Browsing by Author "Yáñez, Julián"

Now showing items 1-11 of 11

    • A nop56 Zebrafish Loss-of-Function Model Exhibits a Severe Neurodegenerative Phenotype 

      Quelle Regaldie, Ana; Folgueira, Mónica; Yáñez, Julián; Sobrido Cameán, Daniel; Alba-González, Anabel; Barreiro-Iglesias, Antón; Sobrido, María-Jesús; Sánchez Piñón, Laura (MDPI, 2022)
      [Abstract] NOP56 belongs to a C/D box small nucleolar ribonucleoprotein complex that is in charge of cleavage and modification of precursor ribosomal RNAs and assembly of the 60S ribosomal subunit. An intronic expansion ...

    • Anatomy and Connectivity of the Torus Longitudinalis of the Adult Zebrafish 

      Folgueira, Mónica; Riva Mendoza, Selva; Ferreño Galmán, María Noelia; Castro, Antonio; Bianco, Isaac H.; Anadón, Ramón; Yáñez, Julián (Frontiers, 2020-03-13)
      [Abstract] This study describes the cytoarchitecture of the torus longitudinalis (TL) in adult zebrafish by using light and electron microscopy, as well as its main connections as revealed by DiI tract tracing. In addition, ...

    • Distribution of Neurogranin-Like Immunoreactivity in the Brain and Sensory Organs of the Adult Zebrafish 

      Alba-González, Anabel; Folgueira, Mónica; Castro, Antonio; Anadón, Ramón; Yáñez, Julián (Wiley, 2022-01-11)
      [Abstract] We studied the expression of neurogranin in the brain and some sensory organs (barbel taste buds, olfactory organs, and retina) of adult zebrafish. Database analysis shows zebrafish has two paralog neurogranin ...

    • Effects of Zinc Oxide Nanoparticle Exposure on Human Glial Cells and Zebrafish Embryos 

      Valdiglesias, Vanessa; Alba-González, Anabel; Fernández-Bertólez, Natalia; Touzani, Assia; Ramos-Pan, Lucía; Reis, Ana Teresa; Moreda-Piñeiro, Jorge; Yáñez, Julián; Laffon, Blanca; Folgueira, Mónica (MDPI, 2023-08-01)
      [Abstract] Zinc oxide nanoparticles (ZnO NPs) are among the most widely used nanomaterials. They have multiple applications in cosmetics, textiles, paints, electronics and, recently, also in biomedicine. This extensive use ...

    • Gene-Activated Hyaluronic Acid-Based Cryogels for Cartilage Tissue Engineering 

      López-Seijas, Junquera; Rey-Rico, Ana; Carballo-Pedrares, Natalia; Miranda-Balbuena, Diego; Lamas Criado, Ibán; Yáñez, Julián (Elsevier, 2023)
      [Abstract] Articular cartilage injuries are very frequent lesions that if left untreated may degenerate into osteoarthritis. Gene transfer to mesenchymal stem cells (MSCs) provides a powerful approach to treat these lesions ...

    • Half-Sandwich Ru(p-cymene) Compounds with Diphosphanes: In Vitro and In Vivo Evaluation As Potential Anticancer Metallodrugs 

      Lenis Rojas, Óscar; Robalo, M. Paula; Tomaz, A. I.; Fernandes, Alexandra; Roma-Rodrigues, Catarina; Teixeira, Ricardo Gonçalves; Marques, Fernanda; Folgueira, Mónica; Yáñez, Julián; Alba-González, Anabel; Salamini-Montemurri, Martín; Pech-Puch, Dawrin; Vázquez, Digna; López-Torres, Margarita; Fernández, Alberto; Fernández Sánchez, Jesús José (American Chemical Society (ACS), 2021-02-11)
      [Abstract] Ruthenium(II) complexes are currently considered attractive alternatives to the widely used platinum-based drugs. We present herein the synthesis and characterization of half-sandwich ruthenium compounds formulated ...

    • Manganese Overexposure Alters Neurogranin Expression and Causes Behavioral Deficits in Larval Zebrafish 

      Alba-González, Anabel; Dragomir, Elena; Haghdousti, Golsana; Yáñez, Julián; Dadswell, Chris; González-Méndez, Ramón; Wilson, Stephen W.; Tuschl, Karin; Folgueira, Mónica (MDPI, 2024-04-30)
      [Abstract] Manganese (Mn), a cofactor for various enzyme classes, is an essential trace metal for all organisms. However, overexposure to Mn causes neurotoxicity. Here, we evaluated the effects of exposure to Mn chloride ...

    • Neural Connections of the Torus Semicircularis in the Adult Zebrafish 

      Yáñez, Julián; Hernández Eguiguren, Maider; Anadón, Ramón (Willey, 2024-01-25)
      [Abstract] The torus semicircularis (TS) of teleosts is a key midbrain center of the lateral line and acoustic sensory systems. To characterize the TS in adult zebrafish, we studied their connections using the carbocyanine ...

    • Neurogranin-Like Immunoreactivity in the Zebrafish Brain During Development 

      Alba-González, Anabel; Yáñez, Julián; Anadón, Ramón; Folgueira, Mónica (Springer Nature, 2022-08-26)
      [Abstract] Neurogranin (Nrgn) is a neural protein that is enriched in the cerebral cortex and is involved in synaptic plasticity via its interaction with calmodulin. Recently we reported its expression in the brain of the ...

    • RuII(p-cymene) Compounds as Effective and Selective Anticancer Candidates with No Toxicity in Vivo 

      Lenis Rojas, Óscar; Robalo, M. Paula; Tomaz, A. I.; Carvalho, Andreia; Fernandes, Alexandra; Marques, Fernanda; Folgueira, Mónica; Yáñez, Julián; Vázquez, Digna; López-Torres, Margarita; Fernández, Alberto; Fernández Sánchez, Jesús José (American Chemical Society (ACS), 2018-10-19)
      [Abstract] Ruthenium(II) complexes are currently considered a viable alternative to the widely used platinum complexes as efficient anticancer agents. We herein present the synthesis and characterization of half-sandwich ...

    • The Organization of the Zebrafish Pallium From a Hodological Perspective 

      Yáñez, Julián; Folgueira, Mónica; Lamas Criado, Ibán; Anadón, Ramón (Wiley, 2021-11-11)
      [Abstract] We studied the connections (connectome) of the adult zebrafish pallium using carbocyanine dye tracing and ancillary anatomical methods. The everted zebrafish pallium (dorsal telencephalic area, D) is composed ...