Browsing by Author "Varela-Rodríguez, Bárbara María"
Now showing items 1-14 of 14
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Alteración de la expresión génica de Sor1 y RB1 en distintos modelos de estrés metabólico
Varela-Rodríguez, Bárbara María; Juiz-Valiña, Paula; Sampedro Ares, Lorena; Pena-Bello, Lara; Cordido, Fernando; Sangiao-Alvarellos, Susana (Sociedad Española para el Estudio de la Obesidad (SEEDO), 2018) -
Altered GH-IGF-1 axis in severe obese subjects is reversed after bariatric surgery-induced weight loss and related with low-grade chronic inflammation
Juiz-Valiña, Paula; Pena-Bello, Lara; Cordido, María; Outeiriño-Blanco, Elena; Pértega-Díaz, Sonia; Varela-Rodríguez, Bárbara María; García-Brao, María Jesús; Mena, Enrique; Sangiao-Alvarellos, Susana; Cordido, Fernando (MDPI, 2020-08-12)[Abstract] Endocrine disorders are common in obesity, including altered somatotropic axis. Obesity is characterized by reduced growth hormone (GH) secretion, although the insulin-like growth factor-1 (IGF-1) values are ... -
Avances en la regulación de la obesidad: microARNs, genes y proteínas
Varela-Rodríguez, Bárbara María (2018)[Resumen] La obesidad y el sobrepeso están definidos por la Organización Mundial de la Salud como una acumulación anormal o excesiva de grasa corporal. Desde los años 80 la prevalencia de la obesidad se duplicó y casi ... -
Beneficial effects of bariatric surgery-induced by weight loss on the proteome of abdominal subcutaneous adipose tissue
Varela-Rodríguez, Bárbara María; Juiz-Valiña, Paula; Varela, Luis; Outeiriño-Blanco, Elena; García-Brao, María Jesús; Mena, Enrique; Noguera, José Francisco; Valero-Gasalla, Javier; Cordido, Fernando; Sangiao-Alvarellos, Susana; Bravo, Susana Belén (MDPI, 2020-01-13)[Abstract] Bariatric surgery (BS) is the most effective treatment for obesity and has a positive impact on cardiometabolic risk and in the remission of type 2 diabetes. Following BS, the majority of fat mass is lost from ... -
Central resistance to thyroid hormones in morbidly obese subjects is reversed after bariatric surgery-induced weight loss
Juiz-Valiña, Paula; Cordido, María; Outeiriño-Blanco, Elena; Pértega-Díaz, Sonia; Varela-Rodríguez, Bárbara María; García-Brao, María Jesús; Mena, Enrique; Pena-Bello, Lara; Sangiao-Alvarellos, Susana; Cordido, Fernando (MDPI, 2020-01-28)[Abstract] Endocrine abnormalities are common in obesity, including altered thyroid function. The altered thyroid function of obesity may be due to a mild acquired resistance to the thyroid hormone. The aim of this study ... -
Circulating levels of irisin in hypopituitary and normal subjects
Pena-Bello, Lara; Pértega-Díaz, Sonia; Sangiao-Alvarellos, Susana; Outeiriño-Blanco, Elena; Eiras-Leal, Raquel; Varela-Rodríguez, Bárbara María; Juiz-Valiña, Paula; Pérez-Fontán, Miguel; Cordido, María; Cordido, Fernando (PLoS ONE, 2016-07-29)[Abstract] Context. The recently identified myokine irisin conveys some of the benefits of exercise. Hypopituitarism with adult growth hormone deficiency (HP) is a situation characterized by decreased GH secretion and an ... -
Effect of weight loss after bariatric surgery on thyroid-stimulating hormone levels in euthyroid patients with morbid obesity
Juiz-Valiña, Paula; Outeiriño-Blanco, Elena; Pértega-Díaz, Sonia; Varela-Rodríguez, Bárbara María; García-Brao, María Jesús; Mena, Enrique; Pena-Bello, Lara; Cordido, María; Sangiao-Alvarellos, Susana; Cordido, Fernando (MDPI, 2019-05-20)[Abstract] Obesity is associated with several endocrine abnormalities, including thyroid dysfunction. The objective of this study was to investigate the effect of weight loss after bariatric surgery on thyroid-stimulating ... -
Expresión en levaduras de genes GFP recombinantes en el mutante nup84 del Complejo del Poro Nuclear
Varela-Rodríguez, Bárbara María (2014) -
La expresión génica de FNDC5 en distintos tejidos, y los niveles circulantes de irisina, están modificados por la dieta y las condiciones hormonales
Cordido, Fernando; Varela-Rodríguez, Bárbara María; Juiz-Valiña, Paula; Pena-Bello, Lara; Sangiao-Alvarellos, Susana (Elsevier, 2016) -
FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle
Varela-Rodríguez, Bárbara María; Pena-Bello, Lara; Juiz-Valiña, Paula; Vidal Bretal, Beatriz; Cordido, Fernando; Sangiao-Alvarellos, Susana (Nature, 2016-07-19)[Abstract] Irisin is processed from fibronectin type III domain-containing protein 5 (FNDC5). However, a controversy exists concerning irisin origin, regulation and function. To elucidate the relationship between serum ... -
Glucose and lipid dysmetabolism in a rat model of prediabetes induced by a high-sucrose diet
Burgeiro, Ana; Cerqueira, Manuela G.; Varela-Rodríguez, Bárbara María; Nunes, Sara; Neto, Paula; Pereira, Frederico C.; Reis, Flávio; Carvalho, Eugénia (Multidisciplinary Dixital Publishing Institute, 2017-06-21)[Abstract] Glucotoxicity and lipotoxicity are key features of type 2 diabetes mellitus, but their molecular nature during the early stages of the disease remains to be elucidated. We aimed to characterize glucose and lipid ... -
Metabolic recovery after weight loss surgery is reflected in serum microRNAs
Sangiao-Alvarellos, Susana; Theofilatos, Konstantinos; Barwari, Temo; Gutmann, Clemens; Takov, Kaloyan; Singh, Bhawana; Juiz-Valiña, Paula; Varela-Rodríguez, Bárbara María; Outeiriño-Blanco, Elena; Duregotti, Elisa; Zampetaki, Anna; Lunger, Lukas; Ebenbichler, Christoph; Tilg, Herbert; García-Brao, María Jesús; Willeit, Peter; Mena, Enrique; Kiechl, Stefan; Cordido, Fernando; Mayr, Manuel (BMJ Publishing Group, 2020-10-01)[Abstract] INTRODUCTION: Bariatric surgery offers the most effective treatment for obesity, ameliorating or even reverting associated metabolic disorders, such as type 2 diabetes. We sought to determine the effects of ... -
MiR-19 family impairs adipogenesis by the downregulation of the PPARγ transcriptional network
Juiz-Valiña, Paula; Varela-Rodríguez, Bárbara María; Outeiriño-Blanco, Elena; García-Brao, María Jesús; Mena, Enrique; Cordido, Fernando; Sangiao-Alvarellos, Susana (MDPI, 2022-12-13)[Abstract] microRNAs (miRNAs) are a class of small endogenous RNA that play pivotal roles in both the differentiation and function of adipocytes during the development of obesity. Despite this, only a few miRNA families ... -
Oral glucose-stimulated growth hormone (GH) test in adult GH deficiency patients and controls: potential utility of a novel test
Pena-Bello, Lara; Seoane-Pillado, Teresa; Sangiao-Alvarellos, Susana; Outeiriño-Blanco, Elena; Varela-Rodríguez, Bárbara María; Juiz-Valiña, Paula; Cordido, María; Cordido, Fernando (Elsevier, 2017-06-09)[Abstract] Context. The diagnosis of adult GH deficiency requires confirmation with a GH stimulation test. Oral glucose (OG) administration affects GH secretion, initially decreasing and subsequently stimulating GH ...
