Browsing by Author "Vaamonde-García, Carlos"
Now showing items 1-20 of 22
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15-Deoxy-Δ-12, 14-prostaglandin J2 acts cooperatively with prednisolone to reduce TGF-β-induced pro-fibrotic pathways in human osteoarthritis fibroblasts
Vaamonde-García, Carlos; Malaise, Olivier; Charlier, Edith; Deroyer, Céline; Neuville, Sophie; Gillet, Philippe; Kurth, William; Meijide-Faílde, Rosa; Malaise, Michel G.; De Seny, Dominique (Elsevier, 2019-03-29)[Abstract] Abstract Background/aims: Synovial fibrosis is a pathological process that is observed in several musculoskeletal disorders and characterized by the excessive deposition of extracellular matrix, as well as cell ... -
A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis
Durán-Sotuela, Alejandro; Fernández-Moreno, Mercedes; Suárez-Ulloa, Victoria; Vázquez-García, Jorge; Relaño, Sara; Hermida-Gómez, Tamara; Balboa-Barreiro, Vanesa; Lourido-Salas, Lucía; Calamia, Valentina; Fernández-Puente, Patricia; Ruiz-Romero, Cristina; Fernández-Tajes, Juan; Vaamonde-García, Carlos; de Andrés, María C.; Oreiro, Natividad; Blanco García, Francisco J; Rego-Pérez, Ignacio (BMJ, 2023-04-06)[Abstract] Objectives: To identify mitochondrial DNA (mtDNA) genetic variants associated with the risk of rapid progression of knee osteoarthritis (OA) and to characterise their functional significance using a cellular ... -
Anti-inflammatory potential of ulvan
Flórez-Fernández, Noelia; Rodríguez-Coello, Arianna; Latire, Thomas; Bourgougnon, Natalie; Torres, María Dolores; Buján, Manuela; Muíños, Alexandra; Muíños, Antonio; Meijide-Faílde, Rosa; Blanco García, Francico J; Vaamonde-García, Carlos; Domínguez, Herminia (Elsevier, 2023-12-31)[Abstract] Green seaweeds are a widespread group of marine macroalgae that could be regarded as biorenewable source of valuable compounds, in particular sulfated polysaccharides like ulvans with interesting biological ... -
Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes
Piñeiro-Ramil, María; Flórez-Fernández, Noelia; Ramil-Gómez, Olalla; Torres, María Dolores; Domínguez, Herminia; Blanco García, Francisco J; Meijide-Faílde, Rosa; Vaamonde-García, Carlos (Elsevier, 2022-01-12)[Abstract] Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders. Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as ... -
Effect of balneotherapy in sulfurous water on an in vivo murine model of osteoarthritis
Vaamonde-García, Carlos; Vela Anero, Ángela; Hermida Gómez, Tamara; Burguera, Elena F.; Filgueira-Fernández, P.; Goyanes, Noa; Blanco García, Francisco J; Meijide-Faílde, Rosa (Springer, 2019-11-01)[Abstract] Osteoarthritis (OA) is a chronic joint disease that results in progressive cartilage destruction and subsequently joint dysfunction. Growing evidence indicates beneficial impact of balneological interventions ... -
Generation of human immortalized chondrocytes from osteoarthritic and healthy cartilage
Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Hermida-Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Vaamonde-García, Carlos; Díaz-Prado, Silvia (The British Editorial Society of Bone & Joint Surgery, 2023-01-17)[Abstract] Aims. After a few passages of in vitro culture, primary human articular chondrocytes undergo senescence and loss of their phenotype. Most of the available chondrocyte cell lines have been obtained from cartilage ... -
Hydrogen sulfide biosynthesis is impaired in the osteoarthritic joint
Burguera, Elena F.; Vela Anero, Ángela; Gato Calvo, Lucía; Vaamonde-García, Carlos; Meijide-Faílde, Rosa; Blanco García, Francisco J (Springer, 2019-11-16)[Abstract] Osteoarthritis (OA) is the most common form of arthritis and it is a leading cause of disability in the elderly. Its complete etiology is not known although there are several metabolic, genetic, epigenetic, and ... -
Impairment of glyoxalase-1, an advanced glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis
Trellu, Sabine; Courties, Alice; Jaisson, Stéphane; Gorisse, Laëtitia; Gillery, Philippe; Kerdine-Römer, Saadia; Vaamonde-García, Carlos; Houard, Xavier; Ekhirch, François-Paul; Sautet, Alain; Friguet, Bertrand; Jacques, Claire; Berenbaum, Francis; Sellam, Jérémie (Springer Nature, 2019-01-11)[Abstract] Background: Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme involved in the removal of AGE precursors, especially ... -
Impairment of hydrogen sulfide synthesis in chondrocytes under high glucose environment: a link between type 2 diabetes and osteoarthritis
Vaamonde-García, Carlos; Burguera, Elena F.; Blanco García, Francisco J; Meijide-Faílde, Rosa (Elsevier, 2018) -
Implicación de la disfunción de la cadena respiratoria mitocondrial en la modulación de la respuesta inflamatoria en la artrosis en condrocitos humanos normales en cultivo : efecto de la disfunción mitocondrial en un modelo animal de inflamación articula
Vaamonde-García, Carlos (Universidade da Coruña, 2013)[Resumen] La artrosis (OA) es la patología articular más frecuente en la población, afectando a más del 70% de los mayores de 65 años. Esta enfermedad se caracteriza por la degradación progresiva del cartílago articular ... -
In vitro study of the therapeutic potential of brown crude fucoidans in osteoarthritis treatment
Vaamonde-García, Carlos; Capelo Mera, Emma; Flórez-Fernández, Noelia; Torres, María Dolores; Rivas-Murias, Beatriz; Meijide-Faílde, Rosa; Blanco García, Francisco J; Domínguez, Herminia (MDPI, 2022-11-17)[Abstract] Osteoarthritis, one of the most common joint degenerative pathologies, still has no cure, and current treatments, such as nonsteroidal anti-inflammatory drugs, can cause serious adverse effects when taken for a ... -
Intraarticular administration effect of hydrogen sulfide on an in vivo rat model of osteoarthritis
Vaamonde-García, Carlos; Burguera, Elena F.; Vela-Anero, Á.; Hermida Gómez, Tamara; Filgueira-Fernández, P.; Fernández-Rodríguez, Jennifer Adriana; Meijide-Faílde, Rosa; Blanco García, Francisco J (MDPI, 2020-10-08)[Abstract] Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological ... -
Involvement of mitochondrial dysfunction in the inflammatory response in human mesothelial cells from peritoneal dialysis effluent
Ramil-Gómez, Olalla; López-Pardo, Mirian; Fernández-Rodríguez, Jennifer Adriana; Rodríguez-Carmona, Ana; Pérez-López, Teresa; Vaamonde-García, Carlos; Pérez-Fontán, Miguel; López-Armada, María José (MDPI, 2022-11-04)[Abstract] Recent studies have related mitochondrial impairment with peritoneal membrane damage during peritoneal dialysis (PD) therapy. Here, we assessed the involvement of mitochondrial dysfunction in the inflammatory ... -
Long-term effects of hydrogen sulfide on the anabolic-catabolic balance of articular cartilage in vitro
Vela-Anero, Á.; Hermida Gómez, Tamara; Gato Calvo, Lucía; Vaamonde-García, Carlos; Díaz-Prado, Silvia; Meijide-Faílde, Rosa; Blanco García, Francisco J; Burguera, Elena F. (Elsevier, 2017-08-15)[Abstract] Healthy cartilage maintenance relies on an equilibrium among the anabolic and catabolic processes in chondrocytes. With the onset of osteoarthritis (OA), increased interleukin (IL)-1β levels induce an inhibition ... -
Mitochondrial DNA impact on joint damaged process in a conplastic mouse model after being surgically induced with osteoarthritis
Scotece, Morena; Rego-Pérez, Ignacio; Lechuga-Vieco, Ana Victoria; Centeno, Alberto; Jiménez-Gómez, María Concepción; Filgueira-Fernández, P.; Vaamonde-García, Carlos; Enríquez, José Antonio; Blanco García, Francisco J (Nature, 2021-04-27)[Abstract] It has been suggested that mitochondrial dysfunction and mtDNA variations may contribute to osteoarthritis (OA) pathogenesis. However, the causative link to support this claim is lacking. Here, we surgically-induced ... -
mtDNA variability determines spontaneous joint aging damage in a conplastic mouse model
Scotece, Morena; Vaamonde-García, Carlos; Lechuga-Vieco, Ana Victoria; Centeno Cortés, Alberto; Jiménez Gómez, María Concepción; Filgueira-Fernández, Purificación; Rego-Pérez, Ignacio; Enríquez, José Antonio; Blanco García, Francisco J (Impact Journals, 2022-07-02)[Abstract] Mitochondria and mtDNA variations contribute to specific aspects of the aging process. Here, we aimed to investigate the influence of mtDNA variation on joint damage in a model of aging using conplastic mice. A ... -
Reduced levels of H₂S in diabetes-associated osteoarthritis are linked to hyperglycaemia, Nrf-2/HO-1 signalling downregulation and chondrocyte dysfunction
Piñeiro-Ramil, María; Burguera, Elena F.; Hermida-Gómez, Tamara; Caramés, Beatriz; Oreiro, Natividad; Meijide-Faílde, Rosa; Blanco García, Francisco J; Vaamonde-García, Carlos (MDPI, 2022-03-25)[Abstract] Different findings indicate that type 2 diabetes is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Changes in the ... -
Relevance of the extraction stage on the anti-inflammatory action of fucoidans
Flórez-Fernández, Noelia; Vaamonde-García, Carlos; Torres, María Dolores; Buján, Manuela; Muíños, Alexandra; Lamas-Vázquez, María J.; Meijide-Faílde, Rosa; Blanco García, Francisco J; Domínguez, Herminia (MDPI, 2023-03-01)[Abstract] The anti-inflammatory action of fucoidans is well known, based on both in vitro and some in vivo studies. The other biological properties of these compounds, their lack of toxicity, and the possibility of obtaining ... -
Study of fucoidans as natural biomolecules for therapeutical applications in osteoarthritis
Vaamonde-García, Carlos; Flórez-Fernández, Noelia; Torres Pérez, María Dolores; Lamas Vázquez, María José; Blanco García, Francisco J; Domínguez, Herminia; Meijide-Faílde, Rosa (Elsevier, 2021-01-26)[Abstract] Osteoarthritis (OA) is the most prevalent articular chronic disease. Although, to date there is no cure for OA. Fucoidans, one of the main therapeutic components of brown algae, have emerged as promising molecules ... -
Study of hydrogen sulfide biosynthesis in synovial tissue from diabetes-associated osteoarthritis and its influence on macrophage phenotype and abundance
Lendoiro-Cino, Natalia; Rodríguez-Coello, Arianna; Saborido, Anna; Burguera, Elena F.; Fernández-Rodríguez, Jennifer A.; Meijide-Faílde, Rosa; Blanco García, Francisco J; Vaamonde-García, Carlos (Springer, 2023-06-19)[Abstract] Type 2 diabetes (DB) is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Synovial macrophages from OA patients with DB ...
