Browsing by Author "Uzal-Varela, Rocío"
Now showing items 1-9 of 9
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A Pentadentate Member of the Picolinate Family for Mn(ɪɪ) Complexation and an Amphiphilic Derivative
Pujales-Paradela, Rosa; Carniato, Fabio; Uzal-Varela, Rocío; Brandariz, Isabel; Iglesias, Emilia; Platas-Iglesias, Carlos; Botta, Mauro; Esteban-Gómez, David (Royal Society of Chemistry, 2018-12-04)[Abstract] We report a pentadentate ligand containing a 2,2′-azanediyldiacetic acid moiety functionalized with a picolinate group at the nitrogen atom (H3paada), as well as a lipophylic derivative functionalized with a ... -
Determinación de herbicidas triazínicos y sus metabolitos en el medio marino
Uzal-Varela, Rocío (2016)[Resumen:] En este trabajo se han validado dos métodos para la determinación de nueve triazinas y ocho productos de degradación en agua de mar y sedimentos marinos. Los metódos se basan en la extracción en fase sólida (agua ... -
Endeavor toward Redox-Responsive Transition Metal Contrast Agents Based on the Cross-Bridge Cyclam Platform
Uzal-Varela, Rocío; Rodríguez-Rodríguez, Aurora; Lalli, Daniela; Valencia, Laura; Maneiro, Marcelino; Botta, Mauro; Iglesias, Emilia; Esteban-Gómez, David; Angelovski, Goran; Platas-Iglesias, Carlos (American Chemical Society, 2024-01-10)[Abstract]: We present the synthesis and characterization of a series of Mn(III), Co(III), and Ni(II) complexes with cross-bridge cyclam derivatives (CB-cyclam = 1,4,8,11-tetraazabicyclo[6.6.2]hexadecane) containing acetamide ... -
Expanding the Ligand Classes Used for Mn(II) Complexation: Oxa-aza Macrocycles Make the Difference
Kálmán, Ferenc; Nagy, Viktória; Uzal-Varela, Rocío; Pérez-Lourido, Paulo; Esteban-Gómez, David; Garda, Zoltán; Pota, Kristof; Mezei, Roland; Pallier, Agnès; Tóth, Éva; Platas-Iglesias, Carlos; Tircsó, Gyula (MDPI, 2021-03-10)[Abstract] We report two macrocyclic ligands based on a 1,7-diaza-12-crown-4 platform functionalized with acetate (𝑡O2DO2A²⁻) or piperidineacetamide (𝑡O2DO2AMᴾⁱᵖ) pendant arms and a detailed characterization of the ... -
New contrast agents alternative to those based on gadolinium
Uzal-Varela, Rocío (2022)[Abstract] The main objective of this doctoral thesis is the development of new systems based on transition metal ions with both high thermodynamic stability and kinetic inertness, that may be used in Magnetic Resonance ... -
On the Dissociation Pathways of Copper Complexes Relevant as Pet Imaging Agents
Uzal-Varela, Rocío; Patinec, Véronique; Tripier, Raphaël; Valencia, Laura; Maneiro, Marcelino; Canle, Moisés; Platas-Iglesias, Carlos; Esteban-Gómez, David; Iglesias, Emilia (Elsevier, 2022)[Abstract] Several bifunctional chelators have been synthesized in the last years for the development of new 64Cu-based PET agents for in vivo imaging. When designing a metal-based PET probe, it is important to achieve ... -
Reliable Methods for Determination of Triazine Herbicides and Their Degradation Products in Seawater and Marine Sediments Using Liquid Chromatography-Tandem Mass Spectrometry
Rodríguez-González, N.; Uzal-Varela, Rocío; González-Castro, María-José; Muniategui, Soledad; Beceiro-González, Elisa (Springer Nature, 2017-01-04)[Abstract] Triazines and their degradation products are transported to the aquatic environment, and once there, the probability to reach the marine environment is very high. In this paper, solid phase extraction (SPE) and ... -
Thermodynamic Stability of Mn(II) Complexes with Aminocarboxylate Ligands Analyzed Using Structural Descriptors
Uzal-Varela, Rocío; Pérez-Fernández, Francisco; Valencia, Laura; Rodríguez-Rodríguez, Aurora; Platas-Iglesias, Carlos; Caravan, Peter; Esteban-Gómez, David (ACS, 2022-08-22)[Abstract] We present a quantitative analysis of the thermodynamic stabilities of Mn(II) complexes, defined by the equilibrium constants (log KMnL values) and the values of pMn obtained as −log[Mn]free for total metal and ... -
Understanding the Effect of the Electron Spin Relaxation on the Relaxivities of Mn(II) Complexes with Triazacyclononane Derivatives
Uzal-Varela, Rocío; Valencia, Laura; Lalli, Daniela; Maneiro, Marcelino; Esteban-Gómez, David; Platas-Iglesias, Carlos; Botta, Mauro; Rodríguez-Rodríguez, Aurora (American Chemical Society, 2021-10-07)[Abstract] Investigating the relaxation of water ¹H nuclei induced by paramagnetic Mn(II) complexes is important to understand the mechanisms that control the efficiency of contrast agents used in diagnostic magnetic ...
