Browsing by Author "Serena, Joaquín"

Now showing items 1-20 of 21

    • Association of high serum levels of growth factors with good outcome in ischemic stroke: a multicenter study 

      Sobrino, Tomás; Rodríguez-Yáñez, Manuel; Campos, Francisco; Iglesias-Rey, Ramón; Millán, Mónica; Pérez de la Osa, Natalia; Dávalos, Antonio; Delgado-Mederos, Raquel; Martínez-Domeño, Alejandro; Martí-Fábregas, Joan; Castellanos, María del Mar; Serena, Joaquín; Lago, Aida; Díez-Tejedor, Exuperio; Castillo, José (Springer Nature, 2019-11-25)
      [Abstract] The main objective of this research work was to study the association of serum levels of growth factors (GF) and SDF-1α with the functional outcome and reduction of lesion volume in ischemic stroke patients. In ...

    • Blood biomarker panels for the early prediction of stroke‐associated complications 

      Faura, Júlia; Bustamante, Alejandro; Reverté, Silvia; García-Berrocoso, Teresa; Millán, Mónica; Castellanos, María del Mar; Lara-Rodríguez, Blanca; Zaragoza, Josep; Ventura, Oriol; Hernández-Pérez, María; van Eeendenburg, Cecile; Cardona, Pere; López-Cancio, Elena; Cánovas, David; Serena, Joaquín; Rubiera, Marta; Dávalos, Antoni; Montaner, Joan (American Heart Association, 2021-02-26)
      [Abstract] Background. Acute decompensated heart failure (ADHF) and respiratory tract infections (RTIs) are potentially life‐threatening complications in patients experiencing stroke during hospitalization. We aimed to ...

    • Cav-1 protein levels in serum and infarcted brain correlate with hemorrhagic volume in a mouse model of thromboembolic stroke, independently of rt-PA administration 

      Gubern-Mérida, Carme; Comajoan, Pau; Huguet, Gemma; García-Yebenes, Isaac; Lizasoain, Ignacio; Moro, María Ángeles; Puig-Parnau, Irene; Sánchez, Juan Manuel; Serena, Joaquín; Kádár, Elisabet; Castellanos, María del Mar (Springer Nature, 2022-01-05)
      [Abstract] Thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) is currently the only FDA-approved drug for acute ischemic stroke. However, its administration is still limited due to the associated ...

    • Cerebral hemodynamic reserve and early neurologic deterioration in acute ischemic stroke 

      Álvarez, Francisco José; Segura, Tomás; Castellanos, María del Mar; Leira, Rogelio; Blanco, Miguel; Castillo, José; Dávalos, Antoni; Serena, Joaquín (Sage, 2004-11)
      [Abstract] Early neurological deterioration (END) is associated with increased mortality and morbidity. Although several predictive factors have been reported, there are little data about the hemodynamic factors. Our aim ...

    • Decreased corticospinal tract fractional anisotropy predicts long-term motor outcome after stroke 

      Puig, Josep; Blasco, Gerard; Daunis-i-Estadella, Pepus; Thomalla, Götz; Castellanos, María del Mar; Figueras, Jaume; Remollo, Sebastián; Van Eendenburg, Cecile; Sánchez-González, Javier; Serena, Joaquín; Pedraza, Salvador (American Heart Association, 2013-05-07)
      [Abstract] Background and purpose: Nearly 50% of patients have residual motor deficits after stroke, and long-term motor outcome is difficult to predict. We assessed the predictive value of axonal damage to the corticospinal ...

    • Dyslipidemias and stroke prevention: recommendations of the Study Group of Cerebrovascular Diseases of the Spanish Society of Neurology 

      Palacio-Portilla, Enrique Jesús; Roquer, Jaume; Amaro, Sergio; Arenillas, Juan; Ayo-Martín, Óscar; Castellanos, María del Mar; Freijo Guerrero, María del Mar; Fuentes, Blanca; García Pastor, Andrés; Gomis, Meritxell; Gómez Choco, Manuel; López-Cancio Martínez, Elena; Martínez Sánchez, Patricia; Morales, Ana; Rodríguez-Yáñez, Manuel; Segura, Tomás; Serena, Joaquín; Vivancos-Mora, José; Alonso de Ceciñana, María (Elsevier, 2022-01)
      [Abstract] Objective: We present an update of the Spanish Society of Neurology's recommendations for prevention of both primary and secondary stroke in patients with dyslipidaemia. Development: We performed a ...

    • Embolism in acute middle cerebral artery stenosis 

      Segura, Tomás; Serena, Joaquín; Castellanos, María del Mar; Teruel, Jordi J.; Vilar, Carlos; Dávalos, Antoni (Wolters Kluwer, 2001-02-27)
      [Abstract] Objective: To investigate the frequency of middle cerebral artery (MCA) stenosis in a series of nonselected patients and the coexistence of microembolic signals with stenosis. Methods: MCA stenosis was ...

    • High plasma glutamate concentrations are associated with infarct growth in acute ischemic stroke 

      Castellanos, María del Mar; Sobrino, Tomás; Pedraza, Salvador; Moldes, Octavio; Pumar, José Manuel; Silva, Yolanda; Serena, Joaquín; García-Gil, María del Mar; Castillo, José; Dávalos, Antoni (American Academy of Neurology, 2008-12-02)
      [Abstract] Background: Excitotoxic and inflammatory mechanisms have been demonstrated as mediating early neurologic deterioration (END) in patients with cerebral infarction. Here we investigate whether molecular markers ...

    • Increased plasma levels of 15-deoxyDelta prostaglandin J2 are associated with good outcome in acute atherothrombotic ischemic stroke 

      Blanco, Miguel; Moro, María Ángeles; Dávalos, Antonio; Leira, Rogelio; Castellanos, María del Mar; Serena, Joaquín; Vivancos, José; Rodríguez-Yáñez, Manuel; Lizasoain, Ignacio; Castillo, José (American Heart Association, 2005-05-05)
      [Abstract] Background and purpose: The 15-deoxyDelta prostaglandin J2 (15-dPGJ2) is an anti-inflammatory prostaglandin that has been proposed to be the endogenous ligand of peroxisome proliferator-activated receptor-gamma ...

    • Inflammation-mediated damage in progressing lacunar infarctions: a potential therapeutic target 

      Castellanos, María del Mar; Castillo, José; García, María M.; Leira, Rogelio; Serena, Joaquín; Chamorro, Ángel; Dávalos, Antoni (American Heart Association, 2002-04-01)
      [Abstract] Background and purpose: The mechanisms underlying neurological deterioration in patients with lacunar infarction are not completely understood. In this study, we sought to investigate the role of proinflammatory ...

    • Microembolic signal monitoring in hemispheric acute ischaemic stroke: a prospective study 

      Serena, Joaquín; Segura, Tomás; Castellanos, María del Mar; Dávalos, Antoni (Karger, 2000-06-22)
      [Abstract] Background and purpose: There are few data on the occurrence of microembolic signals (MES) in the acute phase of ischaemic stroke. The objective of our work was to systematically study the frequency of MES ...

    • MiRNA expression is modulated over time after focal ischaemia: up-regulation of miR-347 promotes neuronal apoptosis 

      Gubern-Mérida, Carme; Camós, Susanna; Ballesteros, Iván; Rodríguez, Rocío; Romera, Víctor G.; Cañadas, Roberto; Lizasoain, Ignacio; Moro, María Ángeles; Serena, Joaquín; Mallolas, Judith; Castellanos, María del Mar (FEBS Press, 2013-10-01)
      [Abstract] Despite the large number of molecules reported as being over-expressed after ischaemia, little is known regarding their regulation. miRNAs are potent post-transcriptional regulators of gene expression, and reports ...

    • Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke 

      Castellanos, María del Mar; Leira, Rogelio; Serena, Joaquín; Pumar, José Manuel; Lizasoain, Ignacio; Castillo, José; Dávalos, Antoni (American Heart Association, 2002-12-05)
      [Abstract] Background and purpose: Matrix metalloproteinase-9 (MMP-9) activity has been associated with hemorrhagic transformation (HT) in experimental models of cerebral ischemia. Our aim was to investigate the relationship ...

    • Pre-existing cerebral small vessel disease limits early recovery in patients with acute lacunar infarct 

      Gómez-Choco, Manuel; Mengual, Juan José; Rodríguez-Antigüedad, Jon; Paré-Curell, Martí; Purroy, Francisco; Palomeras, Ernest; Fuentes, Blanca; Ustrell, Xavier; Tembl, José; Rodríguez-Yáñez, Manuel; Castellanos, María del Mar; Martí-Fábregas, Joan; Serena, Joaquín (Elsevier, 2019-11)
      [Abstract] Background and purpose: To assess whether neuroimaging markers of chronic cerebral small vessel disease (cSVDm) influence early recovery after acute ischemic stroke (AIS). Methods: Retrospective analysis ...

    • Prevención de ictus en pacientes con diabetes mellitus tipo 2 o prediabetes: recomendaciones del Grupo de Estudio de Enfermedades Cerebrovasculares de la Sociedad Española de Neurología 

      Fuentes, Blanca; Amaro, Sergio; Alonso de Ceciñana, María; Arenillas, Juan; Ayo-Martín, Óscar; Castellanos, María del Mar; Freijo Guerrero, María del Mar; García Pastor, Andrés; Gomis, Meritxell; Gómez Choco, Manuel; López-Cancio Martínez, Elena; Martínez Sánchez, Patricia; Morales, Ana; Palacio-Portilla, Enrique Jesús; Rodríguez-Yáñez, Manuel; Roquer, Jaume; Segura, Tomás; Serena, Joaquín; Vivancos-Mora, José (Elsevier, 2020-09-24)
      [Resumen] Objetivo. Actualizar las recomendaciones de la Sociedad Española de Neurología para la prevención del ictus en pacientes con DM-2 o prediabetes, analizando las evidencias disponibles sobre el efecto del control ...

    • Recommendations of the Spanish Society of Neurology for the prevention of stroke: interventions on lifestyle and air pollution 

      García Pastor, Andrés; López-Cancio Martínez, Elena; Rodríguez-Yáñez, Manuel; Alonso de Ceciñana, María; Amaro, Sergio; Arenillas, Juan; Ayo-Martín, Óscar; Castellanos, María del Mar; Fuentes, Blanca; Freijo Guerrero, María del Mar; Gomis, Meritxell; Gómez Choco, Manuel; Martínez Sánchez, Patricia; Morales, Ana; Palacio-Portilla, Enrique Jesús; Segura, Tomás; Serena, Joaquín; Vivancos-Mora, José; Roquer, Jaume (Elsevier, 2021-03-27)
      [Abstract] Objective: To update the recommendations of the Spanish Society of Neurology regarding lifestyle interventions for stroke prevention. Development: We reviewed the most recent studies related to lifestyle ...

    • Semi-intensive monitoring in acute stroke and long-term outcome 

      Silva, Yolanda; Puigdemont, Montserrat; Castellanos, María del Mar; Serena, Joaquín; Suñer, Rosa M.; García, María M.; Dávalos, Antoni (Karger, 2005-01-14)
      [Abstract] Background and purpose: Factors that determine the benefit of stroke units (SU) are unknown. The aim of our study was to analyze whether semi-intensive monitoring during the acute phase of stroke reduces mortality ...

    • Serum cellular fibronectin and matrix metalloproteinase-9 as screening biomarkers for the prediction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke: a multicenter confirmatory study 

      Castellanos, María del Mar; Sobrino, Tomás; Millán, Mónica; García, María M.; Arenillas, Juan; Nombela, Florentino; Brea, David; Pérez de la Ossa, Natalia; Serena, Joaquín; Vivancos, José; Castillo, José; Dávalos, Antoni (American Heart Association, 2007-05-03)
      [Abstract] Background and purpose: Plasma levels of cellular fibronectin (c-Fn) > or =3.6 microg/mL and of matrix metalloproteinase-9 (MMP-9) > or =140 ng/mL have been associated with parenchymal hematoma (PH) after ...

    • Statin treatment withdrawal in ischemic stroke: a controlled randomized study 

      Blanco, Miguel; Nombela, Florentino; Castellanos, María del Mar; Rodríguez-Yáñez, Manuel; García-Gil, María del Mar; Leira, Rogelio; Lizasoain, Ignacio; Serena, Joaquín; Vivancos, José; Moro, María Ángeles; Dávalos, Antoni; Castillo, José (American Academy of Neurology, 2007-08-28)
      [Abstract] Background: Pretreatment with statins has been shown to reduce brain injury in cerebral ischemia. In this controlled randomized study, we investigated the influence of statin pretreatment and its withdrawal on ...

    • Stroke prevention in patients with arterial hypertension: recommendations of the Spanish Society of Neurology's Stroke Study Group 

      Rodríguez-Yáñez, Manuel; Gómez Choco, Manuel; López-Cancio Martínez, Elena; Amaro, Sergio; Alonso de Ceciñana, María; Arenillas, Juan; Ayo-Martín, Óscar; Castellanos, María del Mar; Freijo Guerrero, María del Mar; García Pastor, Andrés; Gomis, Meritxell; Martínez Sánchez, Patricia; Morales, Ana; Palacio-Portilla, Enrique Jesús; Roquer, Jaume; Segura, Tomás; Serena, Joaquín; Vivancos-Mora, José; Fuentes, Blanca (Elsevier, 2021-04-23)
      [Abstract] Objective: To update the recommendations of the Spanish Society of Neurology on primary and secondary stroke prevention in patients with arterial hypertension. Development: We proposed several questions ...