Now showing items 1-9 of 9

    • Exploring genetic outcomes as frailty biomakers 

      Valdiglesias, Vanessa; Sánchez-Flores, María; Marcos-Pérez, Diego; Lorenzo-López, Laura; Maseda, Ana; Millán-Calenti, José Carlos; Pásaro, Eduardo; Laffon, Blanca (Oxford, 2018-04-19)
      [Abstract] Frailty has emerged as a reliable measure of the aging process. Because the early detection of frailty is crucial to prevent or even revert it, the use of biomarkers would allow an earlier and more objective ...
    • Frailty in older adults Is associated with plasma concentrations of inflammatory mediators but not with lymphocyte subpopulations 

      Marcos-Pérez, Diego; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Gostner, Johanna M.; Fuchs, Dietmar; Pasaro, Eduardo; Laffon, Blanca; Valdiglesias, Vanessa (Frontiers, 2018-05-16)
      [Abstract] Frailty denotes a multidimensional syndrome that gives rise to vulnerability to stressors and leads to an increase of the age-related decline of different physiological systems and cognitive abilities. Aging-related ...
    • Frailty status in older adults is related to alterations in indoleamine 2,3-dioxygenase 1 and guanosine triphosphate cyclohydrolase I enzymatic pathways 

      Marcos Pérez, Diego; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Strasser, Barbara; Gostner, Johanna M.; Fuchs, Dietmar; Pásaro, Eduardo; Valdiglesias, Vanessa; Laffon, Blanca (Elsevier para AMDA (The Society for Post-Acute and Long-Term Cara Medicine), 2017-08-08)
    • Frailty syndrome and genomic instability in older adults: suitability of the cytome micronucleus assay as a diagnostic tool 

      Sánchez-Flores, María; Marcos-Pérez, Diego; Lorenzo-López, Laura; Maseda, Ana; Millán-Calenti, José Carlos; Bonassi, Stefano; Pásaro, Eduardo; Laffon, Blanca; Valdiglesias, Vanessa (Oxford, 2018-01-13)
      [Abstract] Frailty, a condition involving increased risk of disability and mortality in older adults, has emerged as a reliable way to predict the effect of aging. Genomic instability may help to anticipate recognition of ...
    • Immune biomarkers in older adults: role of physical activity 

      Valdiglesias, Vanessa; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Marcos Pérez, Diego; López-Cortón Facal, Ana; Strasser, Barbara; Fuchs, Dietmar; Laffon, Blanca; Millán-Calenti, José Carlos; Pasaro, Eduardo (Taylor & Francis, 2017-05-19)
      [Abstract] Aging is associated with a decline in the normal functioning of the immune system. Several studies described the relationship between immunological alterations, including immunosenescence and inflammation, and ...
    • Low Vitamin D Levels and Frailty Status in Older Adults: a Systematic Review and Meta-Analysis 

      Marcos-Pérez, Diego; Sánchez-Flores, María; Bonassi, Stefano; Costa, Solange; Teixeira, Joao Paulo; Fernández-Tajes, Juan; Pásaro, Eduardo; Valdiglesias, Vanessa; Laffon, Blanca (2020)
      [Abstract] Serum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low ...
    • Lymphocyte subsets in a population of nonfrail elderly individuals 

      Valdiglesias, Vanessa; Sánchez-Flores, María; Maseda, Ana; Marcos Pérez, Diego; Millán-Calenti, José Carlos; Pasaro, Eduardo; Lorenzo-López, Laura; Laffon, Blanca (Taylor & Francis, 2015-07-13)
      [Abstract] Age-related frailty is characterized by increased vulnerability to stress due to decline in homeostatic reserve, which results in increased risk of adverse health outcomes including disability, hospitalization, ...
    • Reference ranges of lymphocyte subsets in non-frail older adults 

      Laffon, Blanca; Sánchez-Flores, María; Marcos-Pérez, Diego; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Valdiglesias, Vanessa; Pásaro, Eduardo (Oxford, 2017-06-30)
    • Serum cortisol but not oxidative stress biomarkers are related to frailty: results of a cross-sectional study in Spanish older adults 

      Marcos-Pérez, Diego; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Pasaro, Eduardo; Laffon, Blanca; Valdiglesias, Vanessa (Taylor&Francis, 2019-08-13)
      [Abstract] Frailty is a multidimensional geriatric syndrome of loss of reserves and increased vulnerability to negative health outcomes. Cortisol, the major hormone of the hypothalamic pituitary adrenal (HPA) axis, and ...