Browsing by Author "Rego-Pérez, Ignacio"
Now showing items 1-20 of 44
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A clinical model including protein biomarkers predicts radiographic knee osteoarthritis: a prospective study using data from the Osteoarthritis Initiative
Lourido Salas, Lucía María; Balboa-Barreiro, Vanesa; Ruiz-Romero, Cristina; Rego-Pérez, Ignacio; Camacho Encina, María; Paz González, Rocío; Calamia, Valentina; Oreiro, Natividad; Nilsson, Peter; Blanco García, Francisco J (Elsevier, 2021-04-30) -
A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis
Durán-Sotuela, Alejandro; Fernández-Moreno, Mercedes; Suárez-Ulloa, Victoria; Vázquez-García, Jorge; Relaño, Sara; Hermida-Gómez, Tamara; Balboa-Barreiro, Vanesa; Lourido-Salas, Lucía; Calamia, Valentina; Fernández-Puente, Patricia; Ruiz-Romero, Cristina; Fernández-Tajes, Juan; Vaamonde-García, Carlos; de Andrés, María C.; Oreiro, Natividad; Blanco García, Francisco J; Rego-Pérez, Ignacio (BMJ, 2023-04-06)[Abstract] Objectives: To identify mitochondrial DNA (mtDNA) genetic variants associated with the risk of rapid progression of knee osteoarthritis (OA) and to characterise their functional significance using a cellular ... -
Análisis de marcadores RAPDs en el género Mytilus
Rego-Pérez, Ignacio (2003)[Resumen] Se realiza un análisis poblacional, mediante marcadores RAPDs (Random Amplified Polymorphic DNA), de la estructura genética de 12 poblaciones de mejillón pertenecientes al género Mytilus, procedentes de ... -
Association of accelerated dynamics of telomere sequence loss in peripheral blood leukocytes with incident knee osteoarthritis in Osteoarthritis Initiative cohort
Guillén, Rebeca; Otero, Fátima; Mosquera, Alejandro; Vázquez-Mosquera, María E.; Rego-Pérez, Ignacio; Blanco García, Francisco J; Fernández, José Luis (Nature, 2021-08-05)[Abstract] Osteoarthritis (OA) is a chronic degenerative joint disease, being the main cause of laboral inability. Decreased telomere size in peripheral blood leukocytes (PBL) has been correlated with age-related pathologies, ... -
Descripción de la cohorte PROCOAC (PROspective COhort of A Coruña): cohorte prospectiva española para el estudio de la osteoartritis
Oreiro, Natividad; Raga, Ana C.; Rego-Pérez, Ignacio; Pértega-Díaz, Sonia; Silva-Díaz, María T.; Freire, Mercedes; Fernández-López, Carlos; Blanco García, Francisco J (Elsevier, 2020-11-13)[Resumen] Introducción y objetivo. El uso de cohortes de osteoartritis bien caracterizadas es obligatorio para estudiar y profundizar en el conocimiento en esta enfermedad. En España no existe actualmente ninguna cohorte ... -
Design of a digital-PCR assay to quantify fragmented human mitochondrial DNA
Mosquera, Alejandro; Guillén, Rebeca; Otero, Fátima; Rego-Pérez, Ignacio; Blanco García, Francisco J; Fernández, José Luis (Wiley, 2021-06-11)[Abstract] Digital PCR (dPCR) has been adapted to quantify the proportion of mitochondrial DNA (mtDNA) molecules without and with double-strand DNA breaks (DSBs). This is based on a break-apart approach of two differentially ... -
Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative
Camacho Encina, María; Balboa-Barreiro, Vanesa; Rego-Pérez, Ignacio; Picchi, Florencia; VanDuin, Jennifer; Qiu, Ji; Fuentes, Manuel; Oreiro, Natividad; LaBaer, Joshua; Ruiz-Romero, Cristina; Blanco García, Francisco J (BMJ, 2019-08-30)[Abstract] Objective To find autoantibodies (AAbs) in serum that could be useful to predict incidence of radiographic knee osteoarthritis (KOA). Design A Nucleic-acid Programmable Protein Arrays (NAPPA) platform was ... -
DNA content, karyotypes, and chromosomal location of 18S-5.8S-28S ribosomal loci in some species of bivalve molluscs from the Pacific Canadian coast
González-Tizón, Ana M.; Martínez-Lage, Andrés; Rego-Pérez, Ignacio; Ausió, Juan; Méndez, Josefina (Canadian Science Publishing, 2000-12)[Abstract]: The DNA content of 10 species of bivalve molluscs from British Columbia coast was determined by image analysis, and the karyotypes of the horse clam “Tressus capax”, the bent-nose macoma “Macoma nasuta”, and ... -
Generating Rho-0 cells using mesenchymal stem cell lines
Fernández-Moreno, Mercedes; Hermida Gómez, Tamara; Gallardo, M. Esther; Dalmao-Fernández, Andrea; Rego-Pérez, Ignacio; Garesse, Rafael; Blanco García, Francisco J (PLoS, 2016-10-20)[Abstract] Introduction, The generation of Rho-0 cells requires the use of an immortalization process, or tumor cell selection, followed by culture in the presence of ethidium bromide (EtBr), incurring the drawbacks its ... -
Genetic biomarkers in osteoarthritis: a quick overview
Rego-Pérez, Ignacio; Durán Sotuela, Alejandro; Ramos-Louro, Paula; Blanco García, Francisco J (Faculty Opinions, 2021-11-10)[Abstract] Osteoarthritis (OA) is a chronic musculoskeletal disease with a polygenic and heterogeneous nature. In addition, when clinical manifestations appear, the evolution of the disease is usually already irreversible. ... -
Higher synovial immunohistochemistry reactivity of IL-17A, Dkk1, and TGF-β1 in patients with early psoriatic arthritis and rheumatoid arthritis could predict the use of biologics
Pinto-Tasende, José A.; Fernández-Moreno, Mercedes; Rego-Pérez, Ignacio; Fernández-López, J. Carlos; Oreiro, Natividad; De-Toro, Javier; Blanco García, Francisco J (MDPI, 2024-04-08)[Abstract] Background: Delay in diagnosis and therapy in patients with arthritis commonly leads to progressive articular damage. The study aimed to investigate the immunohistochemical reactivity of synovial cytokines ... -
Identificación y anotación exhaustiva de variantes mitocondriales para la investigación en osteoartritis
Suárez-Ulloa, Victoria; Ramilo Loureiro, S.; Rego-Pérez, Ignacio; Durán Soutela, Alejandro; Ramos-Louro, Paula; Blanco García, Francisco J; Carrajo García, L. (Sociedad Española de Informática de la Salud (SEIS), 2021-04) -
Impaired metabolic flexibility in the osteoarthritis process: a study on transmitochondrial cybrids
Dalmao-Fernández, Andrea; Lund, Jenny; Hermida Gómez, Tamara; Vázquez-Mosquera, María E.; Rego-Pérez, Ignacio; Blanco García, Francisco J; Fernández-Moreno, Mercedes (MDPI, 2020-03-27)[Abstract] Osteoarthritis (OA) is the most frequent joint disease; however, the etiopathogenesis is still unclear. Chondrocytes rely primarily on glycolysis to meet cellular energy demand, but studies implicate impaired ... -
Is It Time for Epigenetics in Osteoarthritis?
Blanco García, Francisco J; Rego-Pérez, Ignacio (Wiley, 2014-05-16)[Abstract] DNA methylation is an epigenetic mechanism of reversible gene regulation which typically results in gene silencing upon hypermethylation in high CpG density regions of promoters (termed CpG islands), and increased ... -
Is osteoarthritis a mitochondrial disease?: what is the evidence
Fernández-Moreno, Mercedes; Rego-Pérez, Ignacio; Blanco García, Francico J (Wolters Kluwer, 2022-01)[Abstract] Propose of review: To summarize the evidence that suggests that osteoarthritis (OA) is a mitochondrial disease. Recent findings: Mitochondrial dysfunction together with mtDNA damage could contribute to cartilage ... -
Leukocyte telomere length in patients with radiographic knee osteoarthritis
Mosquera, Alejandro; Rego-Pérez, Ignacio; Blanco García, Francisco J; Fernández, José Luis (Wiley, 2019-11-29)[Abstract] Relative mean telomere sequence amount was determined by quantitative PCR (qPCR) of peripheral blood leukocyte (PBL) samples obtained at recruitment (n = 310) from individuals from the Osteoarthritis (OA) ... -
Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect
Styrkarsdottir, Unnur; Stefansdottir, Lilja; Thorleifsson, Gudmar; Stefansson, Olafur A.; Saevarsdottir, Saedis; Lund, Sigrun H.; Rafnar, Thorunn; Hoshijima, Kazuyuki; Novak, Kendra; Oreiro, Natividad; Rego-Pérez, Ignacio; Hansen, Channing; Kazmers, Nikolas; Kiemeney, Lambertus A.; Blanco García, Francisco J; Barker, Tyler; Kloppenburg, Margreet; Jurynec, Michel J.; Gudbjartsson, Daniel F.; Jonsson, Helgi; Thorsteinsdottir, Unnur; Stefansson, Kari (BMJ, 2023-03-17)[Abstract] Objectives: Erosive hand osteoarthritis (EHOA) is a severe subset of hand osteoarthritis (OA). It is unclear if EHOA is genetically different from other forms of OA. Sequence variants at ten loci have been ... -
Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort
Silva-Díaz, Maite; Pértega-Díaz, Sonia; Balboa-Barreiro, Vanesa; Tilve-Álvarez, Carlos M.; Raga-Sivira, Ana; Rego-Pérez, Ignacio; Blanco García, Francisco J; Oreiro, Natividad (Springer Nature, 2024-03-12)[Abstract] To delineate the phenotype of erosive hand osteoarthritis (EHOA) in a Spanish population and assess its correlation with metabolic syndrome. We conducted a cross-sectional study using baseline data from the ... -
Mitochondria and Mitophagy: Biosensors for Cartilage Degradation and Osteoarthritis
Blanco García, Francisco J; Rego-Pérez, Ignacio (Elsevier, 2018-05-29) -
Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis
Fernández-Moreno, Mercedes; Soto-Hermida, Ángel; Pértega-Díaz, Sonia; Oreiro, Natividad; Fernández-López, Carlos; Rego-Pérez, Ignacio; Blanco García, Francisco J (BioMed Central, 2011-11-22)[Abstract] Background: Oxidative stress play a main role in the initiation and progression of the OA disease and leads to the degeneration of mitochondria. To prevent this, the chondrocytes possess a well-coordinated ...
