Browsing by Author "Ponte-Fernández, Christian"

Now showing items 1-7 of 7

    • A SIMD Algorithm for the Detection of Epistatic Interactions of Any Order 

      Ponte-Fernández, Christian; González-Domínguez, Jorge; Martín, María J. (Elsevier, 2022)
      [Abstract] Epistasis is a phenomenon in which a phenotype outcome is determined by the interaction of genetic variation at two or more loci and it cannot be attributed to the additive combination of effects corresponding ...

    • Evaluation of Existing Methods for High-Order Epistasis Detection 

      Ponte-Fernández, Christian; González-Domínguez, Jorge; Carvajal-Rodriguez, Antonio; Martín, María J. (Institute of Electrical and Electronics Engineers, 2020-10-15)
      [Abstract] Finding epistatic interactions among loci when expressing a phenotype is a widely employed strategy to understand the genetic architecture of complex traits in GWAS. The abundance of methods dedicated to the ...

    • Fast search of third-order epistatic interactions on CPU and GPU clusters 

      Ponte-Fernández, Christian; González-Domínguez, Jorge; Martín, María J. (Sage Publications Ltd., 2019-05-27)
      [Abstract] Genome-Wide Association Studies (GWASs), analyses that try to find a link between a given phenotype (such as a disease) and genetic markers, have been growing in popularity in the recent years. Relations between ...

    • Fiuncho: a program for any-order epistasis detection in CPU clusters 

      Ponte-Fernández, Christian; González-Domínguez, Jorge; Martín, María J. (Springer, 2022)
      [Abstract]: Epistasis can be defined as the statistical interaction of genes during the expression of a phenotype. It is believed that it plays a fundamental role in gene expression, as individual genetic variants have ...

    • High-Order Epistasis Detection in High Performance Computing Systems 

      Ponte-Fernández, Christian (2022)
      [Resumo] Nos últimos anos, os estudos de asociación do xenoma completo (Genome-Wide Association Studies, GWAS) están a gañar moita popularidade de cara a buscar unha explicación xenética á presenza ou ausencia de certas ...

    • PyToxo: a Python tool for calculating penetrance tables of high-order epistasis models 

      González-Seoane, Borja; Ponte-Fernández, Christian; González-Domínguez, Jorge; Martín, María J. (BMC, 2022)
      [Abstract] Background Epistasis is the interaction between different genes when expressing a certain phenotype. If epistasis involves more than two loci it is called high-order epistasis. High-order epistasis is an area ...

    • Toxo: A Library for Calculating Penetrance Tables of High-Order Epistasis Models 

      Ponte-Fernández, Christian; González-Domínguez, Jorge; Carvajal-Rodriguez, Antonio; Martín, María J. (BioMed Central Ltd., 2020-04-09)
      [Abstract] Background Epistasis is defined as the interaction between different genes when expressing a specific phenotype. The most common way to characterize an epistatic relationship is using a penetrance table, which ...