Browsing by Author "Pena-Bello, Lara"
Now showing items 1-15 of 15
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Alteración de la expresión génica de Sor1 y RB1 en distintos modelos de estrés metabólico
Varela-Rodríguez, Bárbara María; Juiz-Valiña, Paula; Sampedro Ares, Lorena; Pena-Bello, Lara; Cordido, Fernando; Sangiao-Alvarellos, Susana (Sociedad Española para el Estudio de la Obesidad (SEEDO), 2018) -
Altered GH-IGF-1 axis in severe obese subjects is reversed after bariatric surgery-induced weight loss and related with low-grade chronic inflammation
Juiz-Valiña, Paula; Pena-Bello, Lara; Cordido, María; Outeiriño-Blanco, Elena; Pértega-Díaz, Sonia; Varela-Rodríguez, Bárbara María; García-Brao, María Jesús; Mena, Enrique; Sangiao-Alvarellos, Susana; Cordido, Fernando (MDPI, 2020-08-12)[Abstract] Endocrine disorders are common in obesity, including altered somatotropic axis. Obesity is characterized by reduced growth hormone (GH) secretion, although the insulin-like growth factor-1 (IGF-1) values are ... -
Central resistance to thyroid hormones in morbidly obese subjects is reversed after bariatric surgery-induced weight loss
Juiz-Valiña, Paula; Cordido, María; Outeiriño-Blanco, Elena; Pértega-Díaz, Sonia; Varela-Rodríguez, Bárbara María; García-Brao, María Jesús; Mena, Enrique; Pena-Bello, Lara; Sangiao-Alvarellos, Susana; Cordido, Fernando (MDPI, 2020-01-28)[Abstract] Endocrine abnormalities are common in obesity, including altered thyroid function. The altered thyroid function of obesity may be due to a mild acquired resistance to the thyroid hormone. The aim of this study ... -
Circulating levels of irisin in hypopituitary and normal subjects
Pena-Bello, Lara; Pértega-Díaz, Sonia; Sangiao-Alvarellos, Susana; Outeiriño-Blanco, Elena; Eiras-Leal, Raquel; Varela-Rodríguez, Bárbara María; Juiz-Valiña, Paula; Pérez-Fontán, Miguel; Cordido, María; Cordido, Fernando (PLoS ONE, 2016-07-29)[Abstract] Context. The recently identified myokine irisin conveys some of the benefits of exercise. Hypopituitarism with adult growth hormone deficiency (HP) is a situation characterized by decreased GH secretion and an ... -
Cost-effectiveness analysis of preoperative treatment of acromegaly with somatostatin analogue on surgical outcome
Margusino-Framiñán, Luis; Pértega-Díaz, Sonia; Pena-Bello, Lara; Sangiao-Alvarellos, Susana; Outeiriño-Blanco, Elena; Pita-Gutiérrez, Francisco; Pita-Fernández, Salvador; Cordido, Fernando (Elsevier, 2015-08-20)[Abstract] Context. There is no uniform standard of care for acromegaly. Due to the high costs involved, steps must be taken to ensure the cost-effective delivery of treatment. Objective. Taking the results of an earlier ... -
Effect of oral glucose administration on rebound growth hormone release in normal and obese women: the role of adiposity, insulin sensitivity and ghrelin
Pena-Bello, Lara; Pértega-Díaz, Sonia; Outeiriño-Blanco, Elena; García-Buela, Jesús; Tovar, Sulay; Sangiao-Alvarellos, Susana; Diéguez, Carlos; Cordido, Fernando (PLoS ONE, 2015-03-17)[Abstract] Context. Metabolic substrates and nutritional status play a major role in growth hormone (GH) secretion. Uncovering the mechanisms involved in GH secretion following oral glucose (OG) administration in normal ... -
Effect of weight loss after bariatric surgery on thyroid-stimulating hormone levels in euthyroid patients with morbid obesity
Juiz-Valiña, Paula; Outeiriño-Blanco, Elena; Pértega-Díaz, Sonia; Varela-Rodríguez, Bárbara María; García-Brao, María Jesús; Mena, Enrique; Pena-Bello, Lara; Cordido, María; Sangiao-Alvarellos, Susana; Cordido, Fernando (MDPI, 2019-05-20)[Abstract] Obesity is associated with several endocrine abnormalities, including thyroid dysfunction. The objective of this study was to investigate the effect of weight loss after bariatric surgery on thyroid-stimulating ... -
Evaluation of thyroid hormone replacement dosing in morbidly obese hypothyroid patients after bariatric surgery-induced weight loss
Juiz-Valiña, Paula; Cordido, María; Outeiriño-Blanco, Elena; Pértega-Díaz, Sonia; Urones Cuesta, Paula; García-Brao, María Jesús; Mena, Enrique; Pena-Bello, Lara; Sangiao-Alvarellos, Susana; Cordido, Fernando (MDPI, 2021-08-19)[Abstract] The most frequent endocrine disease in obese patients is hypothyroidism. To date, there are no clear data regarding what happens to the dose of levothyroxine (LT4) after bariatric surgery (BS). The objective of ... -
La expresión génica de FNDC5 en distintos tejidos, y los niveles circulantes de irisina, están modificados por la dieta y las condiciones hormonales
Cordido, Fernando; Varela-Rodríguez, Bárbara María; Juiz-Valiña, Paula; Pena-Bello, Lara; Sangiao-Alvarellos, Susana (Elsevier, 2016) -
FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle
Varela-Rodríguez, Bárbara María; Pena-Bello, Lara; Juiz-Valiña, Paula; Vidal Bretal, Beatriz; Cordido, Fernando; Sangiao-Alvarellos, Susana (Nature, 2016-07-19)[Abstract] Irisin is processed from fibronectin type III domain-containing protein 5 (FNDC5). However, a controversy exists concerning irisin origin, regulation and function. To elucidate the relationship between serum ... -
Implicaciones de la hormona de crecimiento, hormonas gastrointestinales, irisina y "microARNs" en la obesidad
Pena-Bello, Lara (2015)[Resumo]A obesidade é unha das principais preocupacións relacionadas coa saúde pública. Na obesidade prodúcense diferentes alteracións hormonais, como o aumento da leptina e a dlminución da hormona de crecemento (GH) e a ... -
Oral glucose-stimulated growth hormone (GH) test in adult GH deficiency patients and controls: potential utility of a novel test
Pena-Bello, Lara; Seoane-Pillado, Teresa; Sangiao-Alvarellos, Susana; Outeiriño-Blanco, Elena; Varela-Rodríguez, Bárbara María; Juiz-Valiña, Paula; Cordido, María; Cordido, Fernando (Elsevier, 2017-06-09)[Abstract] Context. The diagnosis of adult GH deficiency requires confirmation with a GH stimulation test. Oral glucose (OG) administration affects GH secretion, initially decreasing and subsequently stimulating GH ... -
Perturbation of hypothalamic MicroRNA expression patterns in male rats after metabolic distress: impact of obesity and conditions of negative energy balance
Sangiao-Alvarellos, Susana; Pena-Bello, Lara; Manfredi-Lozano, María; Tena-Sempere, Manuel; Cordido, Fernando (Endocrine Society, 2014-02-11)[Abstract] The hypothalamus plays a crucial role in body weight homeostasis through an intricate network of neuronal circuits that are under the precise regulation of peripheral hormones and central transmitters. Although ... -
Serum levels of the adipomyokine irisin in patients with chronic kidney disease
Rodríguez-Carmona, Ana; Pérez-Fontán, Miguel; Sangiao-Alvarellos, Susana; García Falcón, María Teresa; Pena-Bello, Lara; López-Muñiz, Andrés; Cordido, Fernando (Elsevier, 2016-12-14)[Abstract] Background. Irisin is an adipomyokine with claimed anti-obesity and anti-diabetic effects. This hormone has been insufficiently studied in patients with advanced chronic kidney disease (CKD). Objective. To ... -
Sexual dimorphism on growth hormone secretion after oral glucose administration
Outeiriño-Blanco, Elena; García-Buela, Jesús; Sangiao-Alvarellos, Susana; Brandón-Sandá, Iria; Pena-Bello, Lara; Pértega-Díaz, Sonia; Martínez, T.; Cordido, Fernando (Thieme, 2012-02-16)[Abstract] Sexual dimorphism of GH secretion is unclear in humans. There is evidence that oral glucose (OG) administration initially decreases and subsequently stimulates GH secretion. Our aim was to study fasting GH ...