Browsing by Author "Pech-Puch, Dawrin"
Now showing items 1-12 of 12
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Absolute Configuration by Vibrational Circular Dichroism of Anti-inflammatory Macrolide Briarane Diterpenoids From the Gorgonian Briareum Asbestinum
Pech-Puch, Dawrin; Joseph-Nathan, Pedro; Burgueño-Tapia, Eleuterio; González-Salas, Carlos; Martínez Matamoros, Diana; Pereira, David; Pereira, Renato; Jiménez, Carlos; Rodríguez, Jaime (Springer Nature, 2021-01-12)[Abstract] The four new briarane diterpenoids 2-butyryloxybriarane B-3 (2), 9-acetylbriarenolide S (3), briarenolide W (4), and 12-isobriarenolide P (5), along with briarane B-3 (1) and the five known diterpenes 6–10 were ... -
Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp.
Pech-Puch, Dawrin; Grilo, Diana; Calva Pérez, Susana Eunice; Pedras, Andreia; Villegas-Hernández, Harold; Guillén-Hernández, Sergio; Díaz-Gamboa, Raúl E.; Forero, Abel M.; Rodríguez, Jaime; Lenis Rojas, Óscar; Jiménez, Carlos; Pimentel, Catarina (MDPI, 2023-01-06)[Abstract] Invasive fungal infections represent a global health threat. They are associated with high mortality and morbidity rates, partly due to the ineffectiveness of the available antifungal agents. The rampant increase ... -
Antimicrobial Diterpene Alkaloids from an Agelas citrina Sponge Collected in the Yucatán Peninsula
Pech-Puch, Dawrin; Forero, Abel M.; Fuentes-Monteverde, Juan Carlos; Lasarte-Monterrubio, Cristina; Martínez Guitián, Marta; González-Salas, Carlos; Guillén-Hernández, Sergio; Villegas-Hernández, Harold; Beceiro, Alejandro; Griesinger, Christian; Rodríguez, Jaime; Jiménez, Carlos (MDPI, 2022-04-28)[Abstract] Three new diterpene alkaloids, (+)-8-epiagelasine T (1), (+)-10-epiagelasine B (2), and (+)-12-hydroxyagelasidine C (3), along with three known compounds, (+)-ent-agelasine F (4), (+)-agelasine B (5), and ... -
Antiviral and Antiproliferative Potential of Marine Organisms from the Yucatan Peninsula, Mexico
Pech-Puch, Dawrin; Berastegui-Cabrera, Judith; Pérez Povedano, Mar Anabel; Villegas-Hernández, Harold; Guillén-Hernández, Sergio; Cautain, Bastien; Reyes, Fernando; Pachón, Jerónimo; Gómez, Patricia; Rodríguez, Jaime; Jiménez, Carlos; Sánchez-Céspedes, Javier (Frontiers, 2020-08-20)[Abstract] Viral infections are one of the main human health problems in recent decades and the cancer remains one of the most lethal diseases worldwide. The development of new antiviral drugs for the treatment of human ... -
Cytotoxic furanoditerpenes from the sponge Spongia tubulifera collected in the Mexican Caribbean
Pech-Puch, Dawrin; Rodríguez, Jaime; Cautain, Bastien; Sandoval-Castro, Carlos Alfredo; Jiménez, Carlos (MDPI, 2019-07-16)[Abstract] Two new spongian furanoditerpenes, 3β-hydroxyspongia-13(16),14-dien-2-one (1) and 19-dehydroxy-spongian diterpene 17 (2), along with five known terpenes, the spongian furanoditerpenes 9-nor-3-hydroxyspongia-3, ... -
Dermacozine N, the First Natural Linear Pentacyclic Oxazinophenazine with UV–Vis Absorption Maxima in the Near Infrared Region, along with Dermacozines O and P Isolated from the Mariana Trench Sediment Strain Dermacoccus abyssi MT 1.1ᵀ
Juhasz, Bertalan; Pech-Puch, Dawrin; Tabudravu, Jioji; Cautain, Bastien; Reyes, Fernando; Jiménez, Carlos; Kyeremeh, Kwaku; Jaspars, Marcel (MDPI, 2021-06-03)[Abstract] Three dermacozines, dermacozines N–P (1–3), were isolated from the piezotolerant Actinomycete strain Dermacoccus abyssi MT 1.1ᵀ, which was isolated from a Mariana Trench sediment in 2006. Herein, we report the ... -
Furanoditerpenes from Spongia (Spongia) tubulifera Display Mitochondrial-Mediated Neuroprotective Effects by Targeting Cyclophilin D
Alvariño, Rebeca; Alfonso, Amparo; Pech-Puch, Dawrin; Gegunde, Sandra; Rodríguez, Jaime; Vieytes, Mercedes R.; Jiménez, Carlos; Botana, Luis M. (American Chemical Society, 2022-07-28)[Abstract] Neuroprotective properties of five previously described furanoditerpenes 1–5, isolated from Spongia (Spongia) tubulifera, were evaluated in an in vitro oxidative stress model in SH-SY5Y cells. Dose–response ... -
Half-Sandwich Ru(p-cymene) Compounds with Diphosphanes: In Vitro and In Vivo Evaluation As Potential Anticancer Metallodrugs
Lenis Rojas, Óscar; Robalo, M. Paula; Tomaz, A. I.; Fernandes, Alexandra; Roma-Rodrigues, Catarina; Teixeira, Ricardo Gonçalves; Marques, Fernanda; Folgueira, Mónica; Yáñez, Julián; Alba-González, Anabel; Salamini-Montemurri, Martín; Pech-Puch, Dawrin; Vázquez, Digna; López-Torres, Margarita; Fernández, Alberto; Fernández Sánchez, Jesús José (American Chemical Society (ACS), 2021-02-11)[Abstract] Ruthenium(II) complexes are currently considered attractive alternatives to the widely used platinum-based drugs. We present herein the synthesis and characterization of half-sandwich ruthenium compounds formulated ... -
In Vitro and In Vivo Assessment of the Efficacy of Bromoageliferin, an Alkaloid Isolated from the Sponge Agelas dilatata, against Pseudomonas aeruginosa
Pech-Puch, Dawrin; Pérez Povedano, Mar Anabel; Martínez-Guitián, Marta; Lasarte-Monterrubio, Cristina; Vázquez-Ucha, Juan Carlos; Bou, Germán; Rodríguez, Jaime; Beceiro, Alejandro; Jiménez, Carlos (MDPI, 2020-06-23)[Abstract] The pyrrole-imidazoles, a group of alkaloids commonly found in marine sponges belonging to the genus Agelas, display a wide range of biological activities. Herein, we report the first chemical study of the ... -
Marine Natural Products from the Yucatan Peninsula
Pech-Puch, Dawrin; Pérez Povedano, Mar Anabel; Lenis Rojas, Óscar; Rodríguez, Jaime; Jiménez, Carlos (MDPI AG, 2020-01-16)[Abstract] Mexico is one of the three areas of the world with the greatest terrestrial and cultural biological diversity. The diversity of Mexican medicinal flora has been studied for a long time and several bioactive ... -
Marine Organisms from the Yucatan Peninsula (Mexico) as a Potential Natural Source of Antibacterial Compounds
Pech-Puch, Dawrin; Pérez Povedano, Mar Anabel; Gómez, Patricia; Martínez-Guitián, Marta; Lasarte-Monterrubio, Cristina; Vázquez-Ucha, Juan Carlos; Novoa Olmedo, María Lourdes; Guillén-Hernández, Sergio; Villegas-Hernández, Harold; Bou, Germán; Rodríguez, Jaime; Beceiro, Alejandro; Jiménez, Carlos (MDPI, 2020-07-18)[Abstract] A total of 51 sponges (Porifera) and 13 ascidians (Chordata) were collected on the coast of the Yucatan Peninsula (Mexico) and extracted with organic solvents. The resulting extracts were screened for antibacterial ... -
Relative Configuration of Micrograms of Natural Compounds Using Proton Residual Chemical Shift Anisotropy
Nath, Nilamoni; Fuentes-Monteverde, Juan Carlos; Pech-Puch, Dawrin; Rodríguez, Jaime; Jiménez, Carlos; Noll, Markus; Kreiter, Alexander; Reggelin, Michael; Navarro-Vázquez, Armando; Griesinger, Christian (Nature, 2020-09-01)[Abstract] 3D molecular structure determination is a challenge for organic compounds or natural products available in minute amounts. Proton/proton and proton/carbon correlations yield the constitution. J couplings and ...
