Browsing by Author "Mouriño, Antonio"

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26,26,26,27,27,27-Hexadeuterated-1,25-Dihydroxyvitamin D3 (1,25D-d6) As Adjuvant of Chemotherapy in Breast Cancer Cell Lines

Seoane, Samuel; Bermúdez, María José; Sendón Lago, Juan José; Martínez Ordóñez, Anxo; Abdul-Hadi, Soraya; Maestro, Miguel; Mouriño, Antonio; Pérez-Fernández, Román

It has been demonstrated that 1,25-dihydroxyvitamin D3 (1,25D) and some of its analogues have antitumor activity. 1,25D labeled with deuterium (26,26,26,27,27,27-hexadeuterated 1a,25-dihydroxyvitamin D3, or 1,25D-d6) is ...
Design, Synthesis, Evaluation and Structure of Allenic 1α,25-Dihydroxyvitamin D₃ Analogs with Locked Mobility at C-17

Fraga, Ramón; Len, Kateryna; Lutzing, Regis; Laverny, Gilles; Loureiro, Julián; Maestro, Miguel; Rochel, Natacha; Rodríguez-Borges, Enrique; Mouriño, Antonio (Wiley, 2021-08-11)

[Abstract] Vitamin D receptor ligands have potential for the treatment of hyperproliferative diseases and disorders related to the immune system. However, hypercalcemic effects limit their therapeutical uses and call for ...